METHODOLOGICAL DEVELOPMENT OF QUANTITATIVE MRS OF THE BREAST

乳房定量 MRS 的方法发展

• 批准号: 8362830
• 负责人: Patrick John Bolan
• 金额: $ 3.03万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362830
• 关键词: Affect; American; American College of Radiology Imaging Network; Breast; Cessation of life; Clinical; Development; Diagnosis; Diagnostic Neoplasm Staging; Disease; Funding; Goals; Grant; Hour; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Methodology; Methods; Monitor; Multi-Institutional Clinical Trial; NMR Spectroscopy; National Center for Research Resources; Patient Care; Phase; Principal Investigator; Protocols documentation; Reproducibility; Research; Research Infrastructure; Resources; Screening procedure; Series; Source; Techniques; Tumor stage; United States National Institutes of Health; Variant; Woman; cost; improved; malignant breast neoplasm; response; tool; tumor; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Breast cancer is a very common disease, affecting 1 in 8 American women in their lifetimes and causing more than 40,000 deaths each year. The development of new non-invasive tools for screening, diagnosis, tumor staging, and treatment monitoring can help improve the quality of patient care. It has been previously shown by our group that quantitative MR spectroscopy can be used to give an early indication of a tumor's response to therapy. The clinical feasibility of this methodology is currently being investigated in a multi-site clinical trial (ACRIN 6657). The goal of this project is to develop and evaluate improved methods for performing quantitative MR spectroscopy in breast cancer. Several new MR spectroscopy techniques will be developed and compared to the standard ACRIN 6657 MRS protocol. There will be two phases to this project. Phase I will develop and compare these sequences on phantoms and normal volunteers. This phase will last approximately 6 months, at the end of which we will select the most promising of the sequence variations. In this phase we estimate that we will need one 1.5-hour session per week for each of 20 weeks (30 hrs). In Phase II, we will perform a normal reproducibility study on a series of 10 subjects, each studied twice. The acquisition protocol will consist of conventional MRI, followed by the standard ACRIN 6657 MRS acquisition, then followed by the experimental MRS methods.

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