DEVELOPMENT AND DEPLOYMENT OF FLEXIBLE AND SCALABLE CI FOR BIOMED RESEARCH

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 目标 我们在这一核心的目标是解决适应，优化和 在药物发现、细胞和器官建模方面提供生物医学应用， 基于当前和新兴计算、数据和网络的图像重建 基础设施。与此同时，我们必须确保可获得性、可复制性和 执行多尺度所需的大型软件集合的多功能性 分析. 具体目标 目标1：将多尺度生物学代码扩展和调整到高性能集群， 多核处理器：允许应用程序代码利用新的“平衡 单个节点成为大规模共享内存对称的计算机 多处理器（SMP）。 目标2：为多尺度和多物理场提供透明和基于服务的访问 生物医学代码：尽可能多地隐藏复杂性，让科学家能够进行更多的推理 轻松了解开展研究所需的系统或工作流程的逻辑  而不是底层的系统细节 目标3：定义、测试和支持一个完整的网络基础设施： 通过理解外部提供的软件，组装 成为一个位于标准Linux操作系统之上的发行版，并定期 严格测试。 目标4：整合和提供转化研究工具：整合和 测试选定的软件应用程序管道“套件”

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objectives Our objective in this core is to address the practical issues of adapting, optimizing and provisioning biomedical applications in drug discovery, cellular and organ modeling, and image reconstruction based upon current and emerging computing, data and network infrastructures. At the same time, we must ensure the accessibility, reproducibility and versatility of the large ensembles of software that are required to carry out multiscale analysis. Specific Aims Aim 1: Scaling and Adapting Multiscale Biology Codes to High-Performance Clusters and Multicore Processors: To allow application codes to take advantage of a new "balance of machines where individual nodes become large-scale, shared-memory symmetric multiprocessors (SMPs). Aim2: Providing Transparent and Service-Based Access to Multiscale and Multiphysics Biomedical Codes: To hide as much complexity as possible allows scientists to reason more easily about the logic of the systems or workflows required to carry out their research  and less about the low-level system details. Aim 3: Defining, Testing, and Supporting a Complete Cyberinfrastructure: To provide a reproducible cyberenvironment by understanding externally-supplied software, assembling into a distribution that sits on top of a standard Linux operating system, and regularly and rigorously testing. Aim 4: Integrating and Delivering Tools for Translational Research: To integrate and test selected "suites" of software application pipelines