DEVELOPMENT AND DEPLOYMENT OF FLEXIBLE AND SCALABLE CI FOR BIOMED RESEARCH

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目标 我们在这一核心的目标是解决适应，优化和提供药物发现，细胞和器官建模，图像重建基于当前和新兴的计算，数据和网络基础设施的生物医学应用的实际问题。与此同时，我们必须确保进行多尺度分析所需的大量软件的可访问性、可再现性和多功能性。 具体目标 目标1：将多尺度生物学代码扩展和调整到高性能集群和多核处理器：允许应用程序代码利用新的“机器平衡”，其中单个节点成为大规模共享内存对称多处理器（SMP）。 目标2：为多尺度和多物理场提供透明和基于服务的访问 生物医学代码：为了尽可能地隐藏复杂性，科学家们可以更容易地推理进行研究所需的系统或工作流程的逻辑  而不是底层的系统细节 目标3：定义、测试和支持一个完整的网络基础设施：通过理解外部提供的软件，组装成一个位于标准Linux操作系统之上的发行版，并定期进行严格的测试，提供一个可复制的网络基础设施。 目标4：整合和提供转化研究工具：整合和 测试选定的软件应用程序管道“套件”

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objectives Our objective in this core is to address the practical issues of adapting, optimizing and provisioning biomedical applications in drug discovery, cellular and organ modeling, and image reconstruction based upon current and emerging computing, data and network infrastructures. At the same time, we must ensure the accessibility, reproducibility and versatility of the large ensembles of software that are required to carry out multiscale analysis. Specific Aims Aim 1: Scaling and Adapting Multiscale Biology Codes to High-Performance Clusters and Multicore Processors: To allow application codes to take advantage of a new "balance of machines where individual nodes become large-scale, shared-memory symmetric multiprocessors (SMPs). Aim2: Providing Transparent and Service-Based Access to Multiscale and Multiphysics Biomedical Codes: To hide as much complexity as possible allows scientists to reason more easily about the logic of the systems or workflows required to carry out their research  and less about the low-level system details. Aim 3: Defining, Testing, and Supporting a Complete Cyberinfrastructure: To provide a reproducible cyberenvironment by understanding externally-supplied software, assembling into a distribution that sits on top of a standard Linux operating system, and regularly and rigorously testing. Aim 4: Integrating and Delivering Tools for Translational Research: To integrate and test selected "suites" of software application pipelines