MULTI-COMPONENT T1 AND T2 MAPPING TO STUDY MYELINATION IN MULTIPLE SCLEROSIS

用于研究多发性硬化症中髓鞘形成的多成分 T1 和 T2 作图

• 批准号: 8362944
• 负责人: Jason Su
• 金额: $ 1.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362944
• 关键词: Annual Reports; Brain; Demyelinations; Disease; Equilibrium; Funding; Grant; Magnetic Resonance; Magnetic Resonance Imaging; Maps; Multiple Sclerosis; Myelin Sheath; National Center for Research Resources; Physiologic pulse; Principal Investigator; Reading; Relaxation; Research; Research Infrastructure; Resources; Scanning; Source; Spinal Cord; Techniques; Technology; Time; United States National Institutes of Health; Visit; Water; abstracting; brain tissue; cost; myelination

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Multiple sclerosis is a disease characterized by demyelination of the spinal cord and brain tissue. Traditionally, quantitative MR imaging has been hampered by long scan times. However, the mcDESPOT (multi-component driven equilibrium single pulse observation of T1/T2) technique allows for not only fast and accurate mapping of T1 and T2 relaxation times in the whole brain, but also the characterization of two water pools within a voxel. The faster pool is thought to represent water trapped inside a myelin sheath. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 多发性硬化症是一种以脊髓和脑组织脱髓鞘为特征的疾病。传统上，定量 磁共振成像因扫描时间长而受到阻碍。然而，mcDESPOT（多组分驱动平衡单 T1/T2 的脉冲观察）技术不仅可以快速准确地绘制 T1 和 T2 弛豫时间 整个大脑，而且还表征体素内的两个水池。速度更快的池被认为代表水 被困在髓鞘内。 要了解卢卡斯中心正在进行的其他项目，请访问 http://rsl.stanford.edu/（卢卡斯年度报告和 ISMRM 2011 摘要）