REWARD PROCESSING IN ADOLESCENTS WITH FIRST EPISODE MANIA

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 摘要目的：评估首发躁狂症青少年在奖赏加工过程中的表现和神经激活情况。 (BD)和健康对照组(HC)，假设患有BD的人在腹侧表现出比HC更大的激活 纹状体(伏隔核)和杏仁核在预期收益中。据预测，这些激活将更加强劲 在奖励任务之前有一个充满感情的素数。 方法：对在过去9个月内确诊的青少年双相I型障碍(N=21)，年龄13~18岁。 与年龄和性别相当的健康儿童(HC，N=23)一起招募，没有任何精神疾病诊断。科目 受试者被给予一个带有前置条件的扫描仪内标准化货币激励延迟(MID，Knutson等人，2001)任务 情绪感应。使用3T GE Signa扫描仪采集功能磁共振图像，使用标准整体- Head线圈(通用电气，密尔沃基)和高分辨率、T1加权、坏草图像。一个完整的大脑小组 通过计算对比度图像的t检验来执行分析，以确定每个试验的预期回报和损失。这个 用单因素方差分析评估启动对各组的影响。 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/(卢卡斯年度报告和 ISMRM 2011年摘要)

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To evaluate performance and neural activation during reward processing in adolescents with first episode mania (BD) and healthy controls (HC), hypothesizing that those with BD will exhibit greater activation than will HC in the ventral striatum (nucleus accumbens) and amygdala in anticipating gains. These activations were predicted to be more robust with an affective prime preceding the reward task. Methods: Adolescents (ages 13-18 years) with bipolar I disorder (N=21) diagnosed within the previous 9 months were recruited along with age and gender comparable healthy children (HC, N=23) without any psychiatric diagnoses. Subjects were given an in-scanner standardized monetary incentive delay (MID, Knutson et al., 2001) task with an antecedent mood induction. Functional magnetic resonance images were acquired with a 3T GE Signa scanner using a standard whole- head coil (General Electric, Milwaukee) and high-resolution, T1-weighted, spoiled GRASS images. A whole brain group analysis was performed by computing t-tests on contrast images for anticipated rewards and losses for each trial. The effects of priming on the groups were evaluated using a groupxprime ANOVA. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)