DENDRITIC CA SIGNALS IN STRIATAL MEDIUM SPINY NEURONS

纹状体中棘神经元中的树突 CA 信号

• 批准号: 8362499
• 负责人: Bernardo L Sabatini
• 金额: $ 2.11万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362499
• 关键词: Buffers; Calcium Channel; Cells; Corpus striatum structure; Coupled; Dendrites; Dendritic Spines; Dependence; Diffusion; Excitatory Synapse; Funding; Glutamate Receptor; Goals; Grant; Ions; Modeling; National Center for Research Resources; Neurons; Parents; Principal Investigator; Research; Research Infrastructure; Resources; Signal Transduction; Source; United States National Institutes of Health; Vertebral column; cost; hippocampal pyramidal neuron; virtual; voltage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We would like to model a dendritic spine as an excitatory synapse, and its associated parent dendrite. Virtual Cell's ability to model ion flux in a voltage sensitive manner gives a powerful and unique framework to do so. The specific goal would be to model a physiologically accurate CA1 pyramidal neuron spine compartment with the following: glutamate receptors (AMPARs, NMDARs (with voltage dependence)), the appropriate voltage sensitive calcium channels (CaV3, CaV1.2/1.3 and CaV2.2/2.3), and SK channels (with intracellular Ca dependence). It is also necessary to accurately model local Ca buffering and diffusion. We would also like to include a dendrite compartment that is electrically and diffusionally coupled to the spine.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们希望将树突棘模型化为兴奋性突触及其相关的亲本树突。虚拟电池以电压敏感的方式模拟离子通量的能力为这样做提供了一个强大而独特的框架。我们的具体目标是建立一个生理上准确的CA1锥体神经元脊髓隔膜：谷氨酸受体(AMPAR、NMDARs)、适当的电压敏感钙通道(CaV3、CaV1.2/1.3和Cav2.2/2.3)和SK通道(细胞内钙依赖)。准确地模拟局部钙的缓冲和扩散也是必要的。我们还希望包括一个与脊柱电和扩散耦合的树枝晶室。