DENDRITIC CA SIGNALS IN STRIATAL MEDIUM SPINY NEURONS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们想把树突棘作为兴奋性突触，以及与之相关的树突。Virtual Cell以电压敏感方式模拟离子通量的能力提供了一个强大而独特的框架。具体目标将是用以下物质对生理学上准确的CA 1锥体神经元脊区室进行建模：谷氨酸受体（AMPAR、NMDAR（具有电压依赖性））、适当的电压敏感性钙通道（CaV 3、CaV 1.2/1.3和CaV 2.2/2.3）和SK通道（具有细胞内Ca依赖性）。还需要精确地模拟局部Ca缓冲和扩散。我们还希望包括一个树突室，是电气和扩散耦合到脊柱。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We would like to model a dendritic spine as an excitatory synapse, and its associated parent dendrite. Virtual Cell's ability to model ion flux in a voltage sensitive manner gives a powerful and unique framework to do so. The specific goal would be to model a physiologically accurate CA1 pyramidal neuron spine compartment with the following: glutamate receptors (AMPARs, NMDARs (with voltage dependence)), the appropriate voltage sensitive calcium channels (CaV3, CaV1.2/1.3 and CaV2.2/2.3), and SK channels (with intracellular Ca dependence). It is also necessary to accurately model local Ca buffering and diffusion. We would also like to include a dendrite compartment that is electrically and diffusionally coupled to the spine.