Peptide Modulation of Striatal Patch and Matrix Subdivisions
纹状体斑块和基质细分的肽调节
基本信息
- 批准号:9125895
- 负责人:
- 金额:$ 41.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-01 至 2018-07-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAxonBasal GangliaBehaviorBiochemicalBiologyBrainCell NucleusCellsCholecystokininCorpus striatum structureCoupledCyclic AMP-Dependent Protein KinasesDevelopmentDiffuseDiseaseDopamineDorsalDrug AddictionDynorphinsElectrophysiology (science)EnkephalinsEquilibriumGeneticGlutamatesGoalsHealthHeartHumanHuntington DiseaseIn VitroIndividualLaboratoriesLightNeuromodulatorNeuronsNeuropeptidesNeurophysiology - biologic functionNeurotransmittersOpioidOpioid ReceptorOpticsParkinson DiseasePathway interactionsPatternPeptide ReceptorPeptide Signal SequencesPeptidesPharmaceutical PreparationsPhysiologic pulsePlayProcessPropertyProteinsReagentReceptor ActivationRegulationResearchRodentRoleRouteSignal PathwaySignal TransductionSiteSliceSomatostatinStagingStructureSubstance PSynapsesSynaptic TransmissionSystemTherapeuticTissuesTransgenic MiceWorkanalogbasebrain cellbrain tissuecellular targetinggamma-Aminobutyric Acidhuman diseaseimprovedin vivoinsightmotor controlneuropeptide Yneuropsychiatric disorderneuropsychiatric symptomneurotransmissionneurotransmitter releasenew technologynoveloptogeneticsreceptor couplingreceptor expressionstriosomesynaptic functiontooltwo-photon
项目摘要
DESCRIPTION (provided by applicant): The mammalian brain, including the human brain, contains dozens of peptides that act as neurotransmitters between cells but whose function and modes of action are relatively unknown. This is particularly true in the basal ganglia in which the
expression of peptides and of peptide receptors varies from cell to cell and nucleus to nucleus. The basal ganglia play a central role in controlling motor action selection - i.e. deciding what we
do - and are at the heart of human disorders such as Parkinson's, Huntington's and drug addiction. We propose to study the function of peptides in the basal ganglia in order to understand how they signal and control the circuitry of this structure. We will make use of new technology developed in the laboratory that allows us to precisely release peptides in mammalian brain tissue using pulses of light. This will be used to analyze peptide function in tissue in which specific classes of neurons are marked or placed under optogenetic control. The proposed work will shed light on the basic biology of this conserved signaling system and will inform how its perturbation contributes to disease.
描述(由申请人提供):哺乳动物的大脑,包括人类的大脑,包含几十种多肽,它们作为细胞之间的神经递质,但其功能和作用方式相对未知。在基底神经节中尤其如此
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Bernardo L Sabatini其他文献
Bernardo L Sabatini的其他文献
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{{ truncateString('Bernardo L Sabatini', 18)}}的其他基金
Action and interaction of ionotropic and metabotropic neurotransmission
离子型和代谢型神经传递的作用和相互作用
- 批准号:
10166240 - 财政年份:2020
- 资助金额:
$ 41.75万 - 项目类别:
Peptide Modulation of Striatal Patch and Matrix Subdivisions
纹状体斑块和基质细分的肽调节
- 批准号:
8589099 - 财政年份:2013
- 资助金额:
$ 41.75万 - 项目类别:
Peptide Modulation of Striatal Patch and Matrix Subdivisions
纹状体斑块和基质细分的肽调节
- 批准号:
8729019 - 财政年份:2013
- 资助金额:
$ 41.75万 - 项目类别:
Scalable Assays for Morphological Analysis of Mammalian Neurons
哺乳动物神经元形态学分析的可扩展测定
- 批准号:
8192511 - 财政年份:2011
- 资助金额:
$ 41.75万 - 项目类别:
DENDRITIC CA SIGNALS IN STRIATAL MEDIUM SPINY NEURONS
纹状体中棘神经元中的树突 CA 信号
- 批准号:
8362499 - 财政年份:2011
- 资助金额:
$ 41.75万 - 项目类别:
Scalable Assays for Morphological Analysis of Mammalian Neurons
哺乳动物神经元形态学分析的可扩展测定
- 批准号:
8657123 - 财政年份:2011
- 资助金额:
$ 41.75万 - 项目类别:
Scalable Assays for Morphological Analysis of Mammalian Neurons
哺乳动物神经元形态学分析的可扩展测定
- 批准号:
8306192 - 财政年份:2011
- 资助金额:
$ 41.75万 - 项目类别:
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