BLUE COPPER PROTEINS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 Cupredoxins是一类I类蓝铜蛋白，通过介导生物电子传递参与植物和细菌的呼吸、合成代谢和分解代谢过程。氨基花青素属于细菌中发现的一类不同的铜氧还蛋白，它不同于其最近的近亲--质蓝蛋白和假天青素，在N-末端区域增加了20个残基。氨基花青素含有一个铜结合部位，带有两个组氨酸、一个半胱氨酸和一个蛋氨酸侧链提供铜配体。氨基花青素通过甲胺脱氢酶(一种以色氨酸色氨酸对苯二酚为辅基的藜麦蛋白)介导ET生成C型细胞色素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cupredoxins comprise a class of Type I blue copper proteins that participate in respiratory, anabolic and catabolic processes in plants and bacteria by mediating biological electron transfer (ET). Amicyanin belongs to a distinct class of cupredoxins found in bacteria, which differs from its closest relatives, plastocyanins and pseudoazurin, by having 20 additional residues at the N-terminal region. Amicyanin contains a copper-binding site with two histidine, one cysteine and one methionine side-chain providing copper ligands. Amicyanin mediates ET from methylamine dehydrogenase , a quinoprotein containing the tryptophan tryptophylquinone as prosthetic group, to c-type cytochromes.