CRYSTAL STRUCTURE STUDIES OF ORNITHINE DECARBOXYLASE ODC1

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 ODC 1，即鸟氨酸脱羧酶1，通常在癌细胞中失调。ODC 1的抑制对于癌症治疗是重要的。本项目的重点是确定ODC 1与我们鉴定的抑制剂复合的晶体结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ODC1, ornithine decarboxylase 1, is usually dysregulated in cancer cells. Inhibition of ODC1 is important for cancer treatment. The focus of current project is to determine the crystals structure of ODC1 complexed with inhibitor that we identified.