CRYSTAL STRUCTURE STUDIES OF ORNITHINE DECARBOXYLASE ODC1

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 ODC1，鸟氨酸脱羧酶1，通常在癌细胞中调节失调。抑制ODC1在癌症治疗中具有重要意义。目前项目的重点是确定我们所确定的与抑制剂络合的ODC1的晶体结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ODC1, ornithine decarboxylase 1, is usually dysregulated in cancer cells. Inhibition of ODC1 is important for cancer treatment. The focus of current project is to determine the crystals structure of ODC1 complexed with inhibitor that we identified.