STRUCTURES OF RIBOSOME-BOUND MODIFIED TRNAS
STRUCTURES OF RIBOSOME-BOUND MODIFIED TRNAS
批准号:
8361726
负责人:
PAUL F AGRIS
金额:
$2.01万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-04-01 至 2012-03-31
关键词:
Amino Acyl-tRNA SynthetasesAnticodonBindingCellular biologyCodon NucleotidesFundingGrantHIVHumanMethodsMolecular BiologyNational Center for Research ResourcesNucleic AcidsNucleosidesPlayPositioning AttributePrincipal InvestigatorProtein BiosynthesisResearchResearch InfrastructureResourcesReverse TranscriptionRibosomal FrameshiftingRibosomesRoleSourceStable Isotope LabelingStructureStructure-Activity RelationshipTransfer RNAUnited States National Institutes of Healthcostprogramsstructural biologytool
中文摘要
这个子项目是利用这些资源的众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Structure-function relationships of nucleic acids, such as that of tRNA in protein synthesis, are fundamental to all cell and molecular biology. In order to probe the structure-function relationships of RNAs as potential targets or tools, we have developed methods for the introduction of native, non-natural, and stable isotope labeled nucleosides. We have found that modified nucleosides in tRNA play an important structural and functional role both within the tRNA molecules and in tRNA anticodon recognition of select codons at the wobble position. Modified nucleosides alter codon "wobble", enhance ribosome binding, explain programmed translational frameshifting, are determinants for aminoacyl-tRNA synthetase recognition, and are involved in human immunodeficiency virus selection of a specific human tRNA to prime reverse transcription.
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科研奖励(0)
会议论文
Modified RNA tools and diagnostics for drug abuse
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批准号:8841583
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项目类别:
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资助金额:$22.5万
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财政年份:2014
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负责人:PAUL F AGRIS
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依托单位:
MODIFIED NUCLEOSIDE STRUCTURE FUNCTION RELATIONS TRNA
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批准号:6120900
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项目类别:
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资助金额:$0.1万
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财政年份:1999
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负责人:PAUL F AGRIS
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依托单位:
TRAINING IN USE OF DMX ELECTRONICS & NMR
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批准号:6120901
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项目类别:
-
资助金额:$0.13万
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财政年份:1999
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负责人:PAUL F AGRIS
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依托单位:
RNA BIOLOGY II--RNA TOOL AND TARGET
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批准号:2461412
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项目类别:
-
资助金额:$0.3万
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财政年份:1997
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负责人:PAUL F AGRIS
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依托单位:
MODIFIED NUCLEOSIDE STRUCTURE FUNCTION RELATIONS TRNA
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批准号:6252039
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项目类别:
-
资助金额:$0.52万
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财政年份:1997
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负责人:PAUL F AGRIS
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依托单位:
MODIFIED NUCLEOSIDE STRUCTURE FUNCTION RELATIONS--TRNA
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批准号:2174035
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项目类别:
-
资助金额:$12.21万
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财政年份:1988
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负责人:PAUL F AGRIS
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依托单位:
MODIFIED NUCLEOSIDE STRUCTURE-FUNCTION RELATIONS--TRNA
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批准号:2174036
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项目类别:
-
资助金额:$12.8万
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财政年份:1988
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负责人:PAUL F AGRIS
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依托单位:
MODIFIED NUCLEOSIDE STRUCTURE-FUNCTION RELATIONS--TRNA
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批准号:6291906
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项目类别:
-
资助金额:$4.65万
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财政年份:1988
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负责人:PAUL F AGRIS
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依托单位:
Modified Nucleoside Structure-Function Relations: tRNA
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批准号:6641850
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项目类别:
-
资助金额:$6.0万
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财政年份:1988
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负责人:PAUL F AGRIS
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依托单位:
Modified Nucleoside Structure-Function Relations: tRNA
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批准号:6700808
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项目类别:
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资助金额:$24.17万
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财政年份:1988
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负责人:PAUL F AGRIS
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依托单位:
Modified Nucleoside Structure-Function Relations: tRNA
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批准号:6621999
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项目类别:
-
资助金额:$24.17万
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财政年份:1988
-
负责人:PAUL F AGRIS
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依托单位:
MODIFIED NUCLEOSIDE STRUCTURE FUNCTION RELATIONS--TRNA
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批准号:2174033
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项目类别:
-
资助金额:$11.84万
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财政年份:1988
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负责人:PAUL F AGRIS
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依托单位:
Modified Nucleoside Structure-Function Relations: tRNA
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批准号:6848304
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项目类别:
-
资助金额:$24.17万
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财政年份:1988
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负责人:PAUL F AGRIS
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依托单位:
MODIFIED NUCLEOSIDE STRUCTURE FUNCTION RELATIONS--TRNA
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批准号:3271477
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项目类别:
-
资助金额:$13.36万
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财政年份:1988
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负责人:PAUL F AGRIS
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依托单位:
MODIFIED NUCLEOSIDE STRUCTURE-FUNCTION RELATIONS--TRNA
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批准号:2391838
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项目类别:
-
资助金额:$12.56万
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财政年份:1988
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负责人:PAUL F AGRIS
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依托单位:
MODIFIED NUCLEOSIDE STRUCTURE-FUNCTION RELATIONS--TRNA
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批准号:2684682
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项目类别:
-
资助金额:$13.32万
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财政年份:1988
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负责人:PAUL F AGRIS
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依托单位:
MODIFIED NUCLEOSIDE STRUCTURE-FUNCTION RELATIONS--TRNA
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批准号:2900505
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项目类别:
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资助金额:$13.66万
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财政年份:1988
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负责人:PAUL F AGRIS
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依托单位:
TRANSFER RNA STRUCTURE DURING PROTEIN SYNTHESIS
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批准号:3271482
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项目类别:
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资助金额:$1.94万
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财政年份:1988
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负责人:PAUL F AGRIS
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依托单位:
Modified Nucleoside Structure-Function Relations: Antiviral peptide function
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批准号:7915574
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项目类别:
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资助金额:$12.95万
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财政年份:1988
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负责人:PAUL F AGRIS
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依托单位:
Modified Nucleoside Structure-Function Relations: tRNA
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批准号:6438098
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项目类别:
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资助金额:$24.17万
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财政年份:1988
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负责人:PAUL F AGRIS
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依托单位:
海外基金