SAG BINDING MOTIF ON ANTIGEN I/II OF STREPTOCOCCUS MUTANS

变形链球菌抗原 I/II 上的 SAG 结合基序

• 批准号: 8361702
• 负责人: Champion Christdoss Selvakumar Deivanayagam
• 金额: $ 0.56万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361702
• 关键词: Adhesions; Bacteria; Binding; Dental caries; Development; Funding; Grant; I-antigen; Membrane Proteins; National Center for Research Resources; Play; Principal Investigator; Research; Research Infrastructure; Resources; Role; Source; Streptococcus mutans; Structure; Therapeutic; United States National Institutes of Health; cost; structural biology; tooth surface

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Streptococcus mutans is a known etiological agent in dental caries. The surface proteins on bacteria play a pivotal role in adhesion to tooth surface, and therefore they become important targets for development of preventative therapeutics. Antigen I/II is one such surface protein on S. mutans, whose importance has been well documented for the last 30 years. In this project, we elucidated both the functional regions, and their respective structures.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 变形链球菌是一种已知的龋病病原体。细菌表面蛋白在牙齿表面的黏附中起着关键作用，因此成为预防治疗发展的重要靶点。抗原I/II是变形链球菌上的一种表面蛋白，其重要性在过去的30年中得到了充分的研究。在这个项目中，我们既阐明了功能区域，也阐明了它们各自的结构。