SPORE in Gastrointestinal Cancer

胃肠癌中的孢子

• 批准号: 8096775
• 负责人: SCOTT E KERN
• 金额: $ 218.5万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-29 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8096775
• 关键词: SPORE; Gastrointestinal; Cancer

This application for continuation of the Specialized Program of Research Excellence (SPORE) in Gastrointestinal Cancer at the Johns Hopkins Medical Institutions supports a highly interactive, multidisciplinary, and inter-institutional program. Seven research projects within three research programs, four cores, a career development and a research developmental program are proposed to extend our translational research in colorectal and pancreatic cancer. Research Program 1: Fundamentals for individualizing patient management (Project 1A, Early detection of human colorectal and pancreatic cancer, Drs. Kinzler and Giardiello; 1B, Pharmacodiagnostics through molecular clues, Drs. Kern and Laheru). Program 2: Developing and understanding novel therapeutics (2A, Antigen-specific monitoring and therapy in pancreatic Ca, Drs. Jaffee and Laheru; 2B, Optimizing and monitoring C. novvi therapy of metastatic colorectal Ca, Drs. Zhou and Diaz). Program 3: Managing and identifying pancreatic neoplasia in the curable stage (3A, Markers for risk in familial pancreatic cancer Hruban, Klein, and Goggins; 3B, Screening markers for persons with high pancreatic cancer susceptibility, Drs. Goggins and Hruban; 3C, Fundamentals of early and variant pancreatic neoplasia, Drs. Maitra, Kern, and Hruban). The cores support the research programs (Core 1, Administration and Communication, Dr. Scott Kern; 2, Human Tissue Research and Logistics, Dr. Ralph Hruban; 3, Familial Cancer Registries, Dr. Frank Giardiello; 4, Statistics/Bioinformatics, Dr. Steven Goodman. The Career Development Program (Dr. Scott Kern) aids the emergence of new investigators and the Research Developmental Program (Dr. Bert Vogelstein) provides rapid funding of innovative directions.

本申请为约翰霍普金斯医疗机构胃肠癌卓越研究专业项目（SPORE）的延续，支持一个高度互动、多学科和机构间的项目。在三个研究项目、四个核心项目、一个职业发展项目和一个研究发展项目中提出了七个研究项目，以扩大我们在结直肠癌和胰腺癌的转化研究。