SPORE in Gastrointestinal Cancer

描述（由申请人提供）：本申请继续在约翰霍普金斯医疗机构的胃肠道癌症卓越研究专业计划（SPORE），支持高度互动，多学科和跨机构的计划。三个研究项目，四个核心，职业发展和研究发展计划中的七个研究项目被提出来扩展我们在结直肠癌和胰腺癌的转化研究。 研究方案一：个体化患者管理的基础（项目1A，人类结直肠癌和胰腺癌的早期检测，Kinzler和Giardiello博士; 1B，通过分子线索进行药物诊断，克恩和Laheru博士）。方案二：开发和理解新的治疗方法（2A，胰腺癌的抗原特异性监测和治疗，Jaffee和Laheru博士; 2B，优化和监测C。转移性结直肠癌的新疗法，Drs. Zhou和迪亚兹）。方案三：在可治愈阶段管理和识别胰腺肿瘤（3A，家族性胰腺癌风险的标志物，Hruban，Klein和Goggins; 3B，胰腺癌易感性高的人的筛查标志物，Drs. Goggins和Hruban; 3C，早期和变异胰腺肿瘤的基础，Drs. Maitra，克恩和Hruban）。 这些核心支持研究项目（核心1，管理和交流，Scott克恩博士; 2，人体组织研究和物流，Ralph Hruban博士; 3，家族性癌症登记，Frank Giardiello博士; 4，统计/生物信息学，Steven Goodman博士。 职业发展计划（Scott克恩博士）有助于新研究人员的出现，研究发展计划（Bert Vogelstein博士）为创新方向提供快速资助。

DESCRIPTION (provided by applicant): This application for continuation of the Specialized Program of Research Excellence (SPORE) in Gastrointestinal Cancer at the Johns Hopkins Medical Institutions supports a highly interactive, multidisciplinary, and inter-institutional program. Seven research projects within three research programs, four cores, a career development and a research developmental program are proposed to extend our translational research in colorectal and pancreatic cancer. Research Program 1: Fundamentals for individualizing patient management (Project 1A, Early detection of human colorectal and pancreatic cancer, Drs. Kinzler and Giardiello; 1B, Pharmacodiagnostics through molecular clues, Drs. Kern and Laheru). Program 2: Developing and understanding novel therapeutics (2A, Antigen-specific monitoring and therapy in pancreatic Ca, Drs. Jaffee and Laheru; 2B, Optimizing and monitoring C. novvi therapy of metastatic colorectal Ca, Drs. Zhou and Diaz). Program 3: Managing and identifying pancreatic neoplasia in the curable stage (3A, Markers for risk in familial pancreatic cancer Hruban, Klein, and Goggins; 3B, Screening markers for persons with high pancreatic cancer susceptibility, Drs. Goggins and Hruban; 3C, Fundamentals of early and variant pancreatic neoplasia, Drs. Maitra, Kern, and Hruban). The cores support the research programs (Core 1, Administration and Communication, Dr. Scott Kern; 2, Human Tissue Research and Logistics, Dr. Ralph Hruban; 3, Familial Cancer Registries, Dr. Frank Giardiello; 4, Statistics/Bioinformatics, Dr. Steven Goodman. The Career Development Program (Dr. Scott Kern) aids the emergence of new investigators and the Research Developmental Program (Dr. Bert Vogelstein) provides rapid funding of innovative directions.