2013 Plant Metabolic Engineering Gordon Research Conference and Gordon Research S

2013植物代谢工程戈登研究大会暨戈登研究会

• 批准号: 8527947
• 负责人: Dean DellaPenna
• 金额: $ 0.4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8527947
• 关键词: Academia; Anabolism; Applied Research; Area; Basic Science; Biochemical; Biochemical Pathway; Biochemistry; Bioinformatics; Biological Factors; Chemicals; Development; Disabled Persons; Fostering; Funding; Health; Human; Industry; Institutes; Institution; Interdisciplinary Study; Joints; Laboratories; Light; Mass Spectrum Analysis; Modeling; New Hampshire; Organism; Participant; Pathway interactions; Physiology; Plants; Production; Research; Research Personnel; Scientist; Series; Signal Transduction; Therapeutic; Time; Woman; base; career; drug development; graduate student; improved; meetings; metabolic engineering; metabolomics; multidisciplinary; next generation; peer; public health relevance; symposium

DESCRIPTION (provided by applicant): Plants produce an enormously diverse array of natural products and while more than 200,000 plant natural products have been characterized to date, this represents but a fraction of the chemical diversity present in the plant kingdom. Given the multiplicity of chiral centers, elaboration with modifying substituents and the selective advantage of plant compounds in plant: herbivore interactions, it is not surprising that plant natural products have specific targets in human biochemistry, signaling and physiology and why two-thirds of compounds now utilized in bedside applications originate from discoveries related to specialized plant metabolites. Accessing and understanding at a fundamental level these taxonomically restricted plant biochemical pathways is essential for improving production levels and bringing new plant compounds into the drug development pipeline. We are fortunate to be researchers at a time when the combined advances in high throughput sequencing, mass spectrometry based metabolomics and bioinformatics are no longer restricted to a handful of model (reference) plant research organisms that contain only a fraction of the chemical diversity in the plant kingdom and instead are being applied to a wide range of "non-model" plant species which are the evolutionary reservoir of taxonomically restricted, plant chemical and biochemical diversity. To provide a setting for the development of the multidisciplinary collaborations needed to unravel the complexity of plant natural product biosynthesis and to advance basic and applied research in plant metabolic engineering in support of drug development activities, we are requesting support for the 2013 Plant Metabolic Engineering Gordon Research Conference (GRC) and joint Gordon Research Seminar (GRS) to be held July 6-12, 2013 at the Waterville Valley conference center in the White Mountains of New Hampshire. In this fifth biennial meeting of this new GRC conference series (initially held in 2005), we expect the number of speakers and participants to approach 160 with representatives from the US and abroad, at all career levels, and representing institutions from academia, industry, private institutes, and federal laboratories. Concerted efforts will continue to encourage the participation of women, persons with disabilities, and scientists from underrepresented groups. The specific aims of this conference are: 1. To support the participation of global leaders in the different areas of plant biochemistry and metabolic engineering that specifically relate to plant pathways of importance to human health. 2. To foster the cross disciplinary interactions needed at all career levels in this research arena. 3. To support the participation of graduate students and postdoctoral researchers, the next generation of plant metabolic engineers, in the Gordon Research Seminar, which provides a unique venue for them to present their research directly to, and network with, their peers?

描述（由申请人提供）：植物产生了各种各样的天然产品，迄今为止已经描述了超过200,000种植物天然产品，但这仅占植物王国中存在的化学多样性的一小部分。鉴于手性中心的多样性，用修饰的取代基和选择性详细说明 植物化合物在植物中的优势：食草动物相互作用，植物天然产品具有人类生物化学，信号传导和生理学的特定靶标，以及为什么现在在床边应用中使用的三分之二的化合物源自与专业植物代谢物有关的发现。在基本水平上获得和理解这些分类学限制的植物生化途径对于提高生产水平并将新植物化合物带入药物开发管道至关重要。我们很幸运能成为研究人员，在高吞吐量测序中的总进展，基于质谱的代谢组学和生物信息学不再仅限于少数模型（参考）植物研究生物体，仅包含植物王中的化学量和植物范围的“植物范围”的植物范围，这些植物范围是“植物范围”的范围，这些植物范围是“量身定量”的范围，这些植物范围是“量身定量”的范围。生化多样性。为了建立开发植物天然产品生物合成复杂性所需的多学科合作，并推进植物代谢工程以支持药物开发活动的基本和应用研究，我们要求支持2013年植物代谢工程工程工程戈登研究会议（GRC）和戈尔德·戈登（GRC）的戈德登研究会议（GRC），以下是7月6日在2013年7月6-12，在2013年7月6-12中，汉普郡。在这个新的GRC会议系列赛（最初于2005年举行）的第五次两年一次的会议上，我们希望演讲者和参与者的人数能够与来自美国和国外的所有职业级别的代表接触160，并代表来自学术界，工业，私人机构和联邦实验室的机构。一致的努力将继续鼓励妇女，残疾人和代表性不足的群体的科学家的参与。本次会议的具体目的是：1。支持全球领导者参与植物生物化学和代谢工程的不同领域，这些领域与对人类健康的重要植物途径特别相关。 2。为了培养该研究领域所有职业水平所需的跨学科互动。 3。为了支持研究生和博士后研究人员的参与，下一代植物代谢工程师参加了戈登研究研讨会，该研讨会为他们提供了一个独特的场所，使他们可以直接向同伴直接向同伴展示研究？