Chemical probes for the study of a unique enzyme from Mycobacterium tuberculosis

用于研究结核分枝杆菌独特酶的化学探针

• 批准号: DP140100174
• 负责人: Prof Craig Hutton
• 金额: $ 27.22万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140100174
• 关键词: Chemical; probes; study; unique; enzyme

The design and chemical synthesis of molecules that selectively inhibit pathogen-specific enzymes is a validated approach toward new therapeutic agents. Mycobacterium tuberculosis contains a unique cytochrome P450 enzyme that catalyses an unusual chemical transformation to generate the product mycocyclosin. This research project will synthesise chemical probes to study the mechanism of this enzyme and the biological role of mycocyclosin. Selective inhibitors of the enzyme will be developed, which will provide a foundation for the exploitation of these molecules in cellular research and medicine.

设计和化学合成选择性抑制病原体特异性酶的分子是开发新治疗剂的有效途径。结核分枝杆菌含有一种独特的细胞色素P450酶，它能催化一种不寻常的化学转化产生霉菌环素。本研究项目将通过合成化学探针来研究该酶的作用机理以及霉菌环素的生物学作用。该酶的选择性抑制剂将被开发出来，这将为这些分子在细胞研究和医学中的开发提供基础。