New synthetic strategies to small cyclic peptides

小环肽的新合成策略

• 批准号: DP180101804
• 负责人: Prof Craig Hutton
• 金额: $ 27.69万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180101804
• 关键词: New; synthetic; strategies; small; cyclic

This project aims to invent new synthetic strategies that enable chemical manipulation of small cyclic peptides, a promising class of biologically active molecules with high metabolic stability. Combining theory and practice, this project will develop novel acyl transfer reactions that will allow traceless, site-selective, ring expansion and contraction of small cyclic peptides. This project will result in new synthetic methodology that will simplify the synthesis of an important class of small drug-like molecules. This will provide significant benefits, such as a breakthrough in the synthetic approach to small cyclic peptides, which will strengthen Australia’s international standing in peptide research and provide new strategies for translation to the growing biotechnology industry.

该项目旨在发明新的合成策略，使化学操作的小环肽，一类有前途的生物活性分子具有高代谢稳定性。结合理论和实践，本项目将开发新的酰基转移反应，使小环肽的无痕，位点选择性，扩环和收缩。该项目将产生新的合成方法，简化一类重要的小药物样分子的合成。这将带来重大利益，例如在小环肽合成方法方面取得突破，这将加强澳大利亚在肽研究方面的国际地位，并为转化为日益增长的生物技术产业提供新的战略。