A new direction in peptide synthesis: an N-to-C approach using thioamides

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The synthesis of amide bonds is one of the most important techniques in organic chemistry. Amide bonds are formed in the production of 65% of all pharmaceuticals, representing one sixth of all chemical processes in this industry. Coupled with the growing significance of peptide-based therapeutics, in which amide bond formation is the central pillar, novel and efficient amide ligation strategies are of great importance. This project aims to develop new synthetic methods for the construction of amides, based on the silver-promoted reaction of carboxylic acids and thioamides. Applications to the synthesis of peptides in the nitrogen-to-carbon direction will be developed, which are expected to enable solid-phase synthesis of carbon-terminally modified peptides, such as thioesters.