PG's and Keratinocyte Adhesion

候选人的目标是通过成为一名翻译科学家来推进她的学术生涯， 由K 08临床医生-科学家发展奖支持的额外基础研究和教学培训。 该候选人是一个助理教授在临床研究-教师终身教职在大学的轨道 罗切斯特医学院急诊医学系。候选人毕业于医学 学校于1998年获得了研究方面的杰出医学博士学位，并成功地结合了 博士后研究在基础研究（80%的努力）与临床实践（20%的努力）。联系她 职业目标，候选人在这里提出一个职业发展计划，使她能够获得 通过专门为教育翻译科学家而设计的课程进行额外培训， 课程提供了最近授予CTSA NIH赠款给我们的机构。此外，候选人将 继续追求她在皮肤癌生物学方面的成功研究计划，再加上高级课程 在基础科学中。为此，候选人发现，在紫外线诱导的皮肤癌中， E-钙粘蛋白（一种介导细胞间接触的粘附分子）的（促癌）下调 角质形成细胞的E-cadherin结构域裂解是翻译后事件，首先由细胞外E-cadherin结构域裂解组成， （主要通过MMPs），随后是内吞作用和蛋白水解/溶酶体-蛋白酶体降解。此外，委员会认为， 这位候选人发现，这一过程是由PGE 2激活EP 2受体调节的 紫外线辐射损伤后局部释放。作为这个K 08奖的一部分，候选人将继续她的研究 这一主题，最终将导致确定新的药物干预目标， 对抗紫外线引发的皮肤癌完成拟议的计划将使候选人获得一个 翻译科学硕士学位是她K 08奖的一部分。由于不同的性质， 建议的培训，候选人已经招募了一个导师委员会，提供必要的 指导、专门知识和支持。总之，这个K 08奖将准备候选人的职业生涯， 基础/转化科学，使她能够（1）确定新的科学发现及其 在实验室动物模型（临床前研究）中的潜在临床有用性，（2）评估此类 通过临床试验发现，以及（3）将其应用于临床实践（从工作台到床边到路边）。

The candidate's goal is to advance her academic career by becoming a translational scientist through additional basic research and didactic training supported by a K08 Clinician-Scientist Development Award. The candidate is an Assistant Professor in the Clinician-Research-Teacher tenure-track at the University of Rochester School of Medicine, Department of Emergency Medicine. The candidate graduated from medical school in 1998 receiving an MD with Distinctions in Research, and since has successfully combined postdoctoral studies in basic research (80% effort) with clinical practice (20% effort). To reach her professional goal, the candidate proposes here a career development plan that will enable her to obtain additional training through coursework specifically designed to educate translational scientists as part of the curriculum available by the recently awarded CTSA NIH grant to our Institution. Moreover, the candidate will continue to pursue her successful research plan in skin cancer biology, coupled with advanced level courses in basic sciences. To this end, the candidate has discovered that in UV-induced skin cancers, the facilitative (pro-oncogenic) down-regulation of E-cadherin, an adhesion molecule mediating cell-cell contacts between keratinocytes, is a post-translational event consisting first of extracellular E-cadherin domain cleavage (primarily by MMPs), followed by endocytosis and proteolytic/lysosomal-proteasomal degradation. Moreover, the candidate has discovered that this process is regulated by activation of the EP2 receptor by PGE2 released locally after UV radiation injury. As part of this K08 award, the candidate will continue her studies on this topic, which ultimately will lead to the identification of new targets for pharmacological intervention against UV-induced skin cancers. Completion of the proposed plan will enable the candidate to receive a Master's in Translational Science degree as part of her K08 award. Due to the diverse nature of the proposed training, the candidate has recruited a mentorial committee that provides the necessary mentorship, expertise and support. In conclusion, this K08 award will prepare the candidate for a career in basic/translational science, whereby she will be able to (1) identify novel scientific discoveries and their potential clinical usefulness in animal models (preclinical studies) in the laboratory, (2) evaluate such discoveries through clinical trials and (3) bring their use to clinical practice (bench-to-bedside-to-curb).