SKP2靶向前列腺癌进展的分子机制-猫眼课题宝

SKP2靶向前列腺癌进展的分子机制

批准号：

8381602

负责人：

Zhenbang Chen

金额：

$12.96万

依托单位：

MEHARRY MEDICAL COLLEGE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/8381602

关键词：

1-Phosphatidylinositol 3-Kinase Acute Adenocarcinoma Advanced Malignant Neoplasm Affect African American Age-Months American Androgens Apoptotic Binding Cancer Control Cancer Patient Castration Caucasians Caucasoid Race Cell Aging Cell Proliferation Cell Survival Cells Cessation of life Chromosomes Complex Data Death Rate Development Disease Down-Regulation E-Cadherin Embryo Epithelial Cells Ethnic group Fibroblasts Growth Homologous Gene Human In Vitro Incidence Investigation Knockout Mice Life Malignant Neoplasms Malignant neoplasm of prostate Mediating Molecular Mus Mutant Strains Mice Mutate Oncogenic Operative Surgical Procedures PC3 cell line PTEN gene Pathway interactions Phosphoric Monoester Hydrolases Phosphorylation Phosphotransferases Prostate Prostatic Intraepithelial Neoplasias Prostatic Neoplasms Proteins Proto-Oncogene Proteins c-akt Race Radiation therapy Recurrence Regulation Resistance Role SKP2 gene Serine Signal Pathway Skp2 Proteins Smooth Muscle Actin Staining Method Specificity TEP1 gene Testing The Vanderbilt-Ingram Cancer Center at the Vanderbilt University Ubiquitination Up-Regulation Wild Type Mouse Xenograft procedure cancer cell cancer diagnosis cancer health disparity cancer statistics deprivation in vivo inhibitor/antagonist male men mortality mouse model oncoprotein p21 overexpression response tumor tumor progression tumor xenograft tumorigenesis wortmannin

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英文摘要

Prostate cancer (PCa) is a prevailing disease found in African American men, and is the most frequently diagnosed cancer in American men. African American males died of PCa in a 2.39-folder higher rate as compared with Caucasian males, while the average death rate due to all cancers was only 1.34-fold higher between these two races (Cancer Statistics 2010)(10). Surgery, radiation therapy and androgen-deprivation therapy have been developed and applied widely to control PCa; however, prostate cancer patients sfill died of Castration Resistant Prostate Cancer (CRPC). Molecular signaling pathways contributing to the initiation and progression of PCa; particulariy, the mechanism of CRPC grovirth remain to be elucidated in order to develop efficient strategies for cancer control. Aberrant regulation of Pten-P13K-Akt pathway, p53 loss and Skp2 activation are commonly found in CRPC. Further investigation on their roles in PCa progression will help us to understand the incidence and mortality rate of PCa, and the disparifies among ethnic and racial groups.

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