Molecular Mechanisms of SKP2 Targeting on Prostate Cancer Progression

前列腺癌（PCa）是在非裔美国男性中发现的流行疾病，并且是美国男性中最常诊断的癌症。与高加索男性相比，非裔美国男性死于前列腺癌的比率高出2.39倍，而这两个种族之间由于所有癌症导致的平均死亡率仅高出1.34倍（癌症统计数据2010）（10）。外科手术、放射治疗和雄激素剥夺疗法已被广泛开发和应用于控制PCa，然而，前列腺癌患者死于前列腺癌。 去势抵抗性前列腺癌（CRPC）。有助于PCa发生和发展的分子信号通路;特别是CRPC生长的机制仍有待阐明，以便开发有效的癌症控制策略。Pten-P13 K-Akt通路的异常调节、p53丢失和Skp 2激活在CRPC中常见。进一步研究它们在PCa进展中的作用将有助于我们了解PCa的发病率和死亡率，以及种族和民族之间的差异。

Prostate cancer (PCa) is a prevailing disease found in African American men, and is the most frequently diagnosed cancer in American men. African American males died of PCa in a 2.39-folder higher rate as compared with Caucasian males, while the average death rate due to all cancers was only 1.34-fold higher between these two races (Cancer Statistics 2010)(10). Surgery, radiation therapy and androgen-deprivation therapy have been developed and applied widely to control PCa; however, prostate cancer patients sfill died of Castration Resistant Prostate Cancer (CRPC). Molecular signaling pathways contributing to the initiation and progression of PCa; particulariy, the mechanism of CRPC grovirth remain to be elucidated in order to develop efficient strategies for cancer control. Aberrant regulation of Pten-P13K-Akt pathway, p53 loss and Skp2 activation are commonly found in CRPC. Further investigation on their roles in PCa progression will help us to understand the incidence and mortality rate of PCa, and the disparifies among ethnic and racial groups.