Molecular Mechanisms of SKP2 Targeting on Prostate Cancer Progression

前列腺癌（PCa）是在非裔美国男性中发现的一种普遍疾病，也是美国男性中最常见的癌症。非裔美国男性死于前列腺癌的比率比白种人男性高2.39倍，而这两个种族之间所有癌症的平均死亡率仅高1.34倍（Cancer Statistics 2010）（10）。手术、放射治疗和雄激素剥夺治疗已发展并广泛应用于控制前列腺癌；然而，前列腺癌患者仍然死于

Prostate cancer (PCa) is a prevailing disease found in African American men, and is the most frequently diagnosed cancer in American men. African American males died of PCa in a 2.39-folder higher rate as compared with Caucasian males, while the average death rate due to all cancers was only 1.34-fold higher between these two races (Cancer Statistics 2010)(10). Surgery, radiation therapy and androgen-deprivation therapy have been developed and applied widely to control PCa; however, prostate cancer patients sfill died of Castration Resistant Prostate Cancer (CRPC). Molecular signaling pathways contributing to the initiation and progression of PCa; particulariy, the mechanism of CRPC grovirth remain to be elucidated in order to develop efficient strategies for cancer control. Aberrant regulation of Pten-P13K-Akt pathway, p53 loss and Skp2 activation are commonly found in CRPC. Further investigation on their roles in PCa progression will help us to understand the incidence and mortality rate of PCa, and the disparifies among ethnic and racial groups.