Research Animal Support

研究动物支持设施(RASF)自最初的CCSG以来一直是共享资源 于1975年获奖，旨在支持正在进行的临床和基础癌症研究，包括实验室 在MDACC的动物。RASF的组件位于休斯顿的MDACC(2个校区)和 癌症发生科的Smithville博士。所有的动物设施都得到了动物协会的认可 国际实验动物保护协会的评估和认可，有动物福利保障 批准(A3343-01)，并在美国农业部注册为研究动物设施 农业(美国农业部)(74-R-065)。休斯顿研究动物支持设施(RASFH)由 RASFH占地约99,089平方英尺。英国《金融时报》的空间，并提供 用于癌症的动物的住房、程序空间、兽医护理和质量保证计划 研究。临床、外科、成像、放射治疗和病理实验室设施和服务 如果是这样的话。现有技术服务已扩展到南校区设施，并有新的服务 自上次CCSG更新以来增加的内容包括计算机化的动物谱系和病史应用程序， 临床前毒理学服务，以及增加的运输服务。新设备包括自动 多种血液学和化学分析仪、患者监测系统、自动床上用品 分配系统和废物箱、货车和100个通风的啮齿动物架/笼系统。这个 RASFH现有人员122人，其中兽医11人，副主任2人，管理员1人，科员2人 管理人员、1名项目经理、10名实验室人员、77名动物护理人员和17名文书/支助人员 工作人员。丁基博士负责协调RASFH的日常运作。五名教职兽医指导这五名 为动物研究使用者提供设施、设备和服务的服务部门。提供资金予 RASFH目前由CCSG(6%)、使用费(39%)、机构支持(53%)和其他基金提供 (2%)。在过去的5年里，RASFH已经被319名调查人员使用，支持20种不同的CCSG 程序。同行评审的调查人员占RASFH用户使用率的92%。大多数人 使用的动物是转基因小鼠。在过去的五年中，日均网箱数量有所增加 52%，由2002-03年度的13,243笼动物增加至2006-07年度的20,132笼动物。未来的计划包括翻新 和扩建南校园动物设施，升级和实施计算机应用程序 用于商业运营和临床前药物开发。此外，RASF-休斯顿和史密斯维尔 联合提交了一份启动计划，以开发突变小鼠病理服务，为所有MDACs提供服务 调查人员。

The Research Animal Support Facility (RASF) has been a shared resource since the original CCSG was awarded in 1975 and exists to support ongoing clinical and basic cancer research involving laboratory animals at MDACC. The RASF has components located in Houston at MDACC (2 campuses), and in Smithville in the Department of Carcinogenesis. All animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care International, have Animal Welfare Assurance approval (A3343-01), and are registered as research animal facilities with the United States Department of Agriculture (USDA) (74-R-065). The Research Animal Support Facility Houston (RASFH) is directed by Peggy T. Tinkey, D.V.M. The RASFH encompasses approximately 99,089 sq. ft. of space and provides housing, procedure space, veterinary care, and quality assurance programs for animals used in cancer research. Clinical, surgical, imaging, radiation therapy, and pathology laboratory facilities and services are provided. Existing technical services have been extended to the South Campus facility, and new services added since the last CCSG renewal include computerized animal pedigree and medical history applications, preclinical toxicology services, and increased transportation services. New equipment includes automated multi-species hematology and chemistry analyzers, patient monitoring systems, automated bedding dispensing systems and waste containers, cargo van, and 100 ventilated rodent rack/cage systems. The RASFH has 122 personnel, which includes 11 veterinarians, 2 associate directors, 1 administrator, 2 section managers, 1 project manager, 10 laboratory personnel, 77 animal care personnel, and 17 clerical/support staff. Dr. Tinkey coordinates the daily operations of the RASFH. Five faculty veterinarians direct the 5 service sections that provide facilities, equipment, and services to research animal users. Funding for the RASFH is currently provided by the CCSG (6%), user fees (39%), institutional support (53%) and other funds (2%). In the past 5 years, the RASFH has been used by 319 investigators supporting 20 different CCSG programs. Peer-reviewed investigators represent 92% of the RASFH user utilization. The majority of animals used are genetically engineered mice. In the past 5 years, the daily average cage counts increased 52%, from 13,243 cages in 2002-03 to 20,132 cages of animals in 2006-07. Future plans include renovation and expansion of the South Campus animal facility, and upgrading and implementing computer applications for business operations and preclinical drug development. Additionally, RASF-Houston and Smithville have jointly submitted a startup proposal to develop a Mutant Mouse Pathology Service to serve all MDACC investigators.