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Immunoincompetent Rodent and Biohazard Facility

免疫功能低下的啮齿动物和生物危害设施

基本信息

批准号：
8379551
负责人：
HERBERT KIM LYERLY
金额：
$ 17.06万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8379551
关键词：
Animal Experimentation Animal Experiments Animals Area Biohazardous Substance Biology Bone Marrow Transplantation Breast Breeding Cancer Biology Caring Cells Chemistry Clinical Containment Containment of Biohazards Ensure Equipment Fees Fever Grant Guidelines HIV Housing Human Human T-Cell Leukemia Viruses Image Immunobiology Inbred BALB C Mice Infectious Agent Institutes Investigational Drugs Label Laboratories Laboratory Animals Lead Luciferases Maintenance Malignant Neoplasms Mechanics Molecular Monoclonal Antibodies Nucleic Acids Nude Mice Nude Rats Operating System Ovarian Procedures Radiation Oncology Radio Radioisotopes Radiolabeled Recombinant DNA Recommendation Regulation Research Personnel Research Support Resource Sharing Resources Rodent Signal Transduction Specific Pathogen Frees Therapeutic Time Toxic effect United States Food and Drug Administration Work animal care animal resource authority biocontainment facility cancer genetics cancer genomics cancer therapy chemical carcinogen clinical application cost design germ free condition immunosuppressed in vivo neuro-oncology oncology program operation programs radiotracer research study small molecule square foot tumor

项目摘要

The Cancer Institute Isolation Facility (CCIF) which houses the Immunoincompetent Rodent and Biocontainment Facility is the oldest shared resource in the Duke Comprehensive Cancer Institute. This facility provides Cancer Institute investigators with special isolated laboratories for work with hazardous biomolecules, certain recombinant DNA procedures, and for the maintenance of immunosuppressed and specific pathogen-free rodents or for other experiments that require biosafety level 2 and 3 containment needed to investigate cancer biology and treatment. The building has a total of 30,000 square feet which includes eight modules housing 3 lead lined rooms, 2 horsfall rooms, 24 animal holding rooms, 8 laboratories, support areas for mechanical equipment, cage washing equipment and 26 operational autoclaves. Request for use of the space in the IRBF is evaluated by an Oversight Committee which makes recommendations to the Director of the Cancer Institute who has the authority to assign space in the building. Each investigator is assessed a fee for the use of the facility to recover the cost of staffing. The facility supports the research of 24 investigators and operates at full capacity. Dr. John N. Norton, Director of the Division of Laboratory Animal Resources and the Director of Operations of the IRBF, has the responsibility of managing and overseeing the animal care program. Dr. Darell Bigner is the scientific Coordinator of the IRBF. The CCIF is staffed with 14 technicians and a shared resource manager who are responsible for providing care to the 8000 cages of rodents which must be maintained under barrier or containment conditions provided by the design ofthe building. The facility is supported by 3 full-time mechanics paid from institutional resources to maintain and ensure the mechanical systems operate within biohazard containment guidelines. The CCIF provides space to support the In Vivo Xenogen and CT Imaging Resource and Radiolabeling Shared Resource.

癌症研究所隔离设施（CCIF），里面有免疫力低下的啮齿动物和