Lung Repair and Regeneration Consortium Administrative Coordinating Center

肺修复与再生联盟行政协调中心

• 批准号: 8223487
• 负责人: Scott M Palmer
• 金额: $ 93.53万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8223487
• 关键词: Acute Lung Injury; Advisory Committees; Affect; Applications Grants; Area; Award; Basic Science; Bioinformatics; Biology; Biometry; Chronic Obstructive Airway Disease; Clinical Research; Collaborations; Communication; Complement; Custom; Development; Education; Educational process of instructing; Electronic Mail; Ensure; Face; Fostering; Funding; Future; Future Generations; Goals; Grant; Grant Review; Growth; Guidelines; Hamman-Rich syndrome; Hand; Home environment; Human Resources; Individual; Industry; Information Technology; Institutes; Instruction; Intellectual Property; Investigation; Knowledge; Language; Lead; Leadership; Lung; Lung diseases; Mentors; Modeling; Monitor; National Heart, Lung, and Blood Institute; Natural regeneration; Online Systems; Patients; Peer Review; Persons; Physicians; Pilot Projects; Principal Investigator; Process; Pulmonology; Qualifying; Reagent; Regenerative Medicine; Regulatory Affairs; Reporting; Research; Research Activity; Research Ethics; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Role; Science; Site; Stem Cell Research; Structure; Teleconferences; Testing; Tissue Engineering; Training; Training Activity; Training and Infrastructure; Translational Research; United States National Institutes of Health; Update; Vision; Web communication; career; design; effective therapy; experience; improved; injury and repair; innovation; lung injury; lung repair; meetings; member; multidisciplinary; novel; programs; repaired; research and development; response; skills; skills training; stem; stem cell biology; success; tool; tool development; translational medicine; virtual; web site

DESCRIPTION (provided by applicant): In response to RFA-HL-12-010, the DTMI proposes to serve as the Administrative Coordinating Center (ACC) for the Lung Repair and Regeneration Consortium (LRRC). This proposal brings together a highly qualified team of individuals, infrastructure, and core resources to fully support the goals of the consortium to advance lung regeneration and repair research. Our ACC Leadership Team includes well-established individuals who bring considerable experience coordinating and leading multicenter research networks, soliciting and reviewing grant application, developing educational training activities, and who possess in- depth knowledge of lung biology and regeneration. The Leadership Team is complemented by the ACC Core Resources Team who will provide scientific support to the Research Centers (RCs) in the areas of bioinformatics, biostatistics, research ethics, intellectual property, and regulatory affairs. Additionally, our ACC structure includes an ACC Senior Advisory Committee comprised of successful independent investigators in lung biology, stem cell research, and tissue engineering who will provide additional guidance to the ACC to ensure a structure that meets the needs of the LRRC. In short, this leadership structure is made up of investigators who understand the complexity of lung biology, can speak the language of basic research, and bring a wealth of experience coordinating multisite networks. They will create an ACC that facilitates communication throughout the LRRC and efficiently accomplish all of the LRRC goals. The ACC Operational Team will consist of project leadership, web and communications expertise, and will be drawn from within the DTMI. These operational resources from within the DTMI have a proven record of web-based network website creation, grant solicitation and oversight, and the development of trainee education programs including a Master's program in Clinical Research co-taught at Duke and the NIH. In summary, the DTMI will foster innovative, streamlined, and highly successful approaches to study coordination, research sub award administration, and web-based communication as the ACC. In order to accomplish these goals, we have developed three specific aims for this consortium: 1) To organize and conduct consortium communication, including teleconferences, in-person meetings, and creation of a web-based, virtual home for the LRRC that synergizes all network functions, 2) To solicit and administer awards to the RCs for collaborative research and tool development projects, and 3) To support the development of the SDC and SDC committee to train a future generation of researchers in lung regeneration and repair. RELEVANCE (See instructions): Enhanced understanding of lung regeneration and repair is critical to develop improved approaches to treat COPD, IPF, and other serious lung disorders. The ACC will facilitate the collaboration, synergy, and sharing of skills training among the RCs, and greatly accelerate the understanding of lung stem cell biology and the processes which regulate lung regeneration and repair. The findings from the LRRC have the potential to improve treatments of lung diseases.

描述（由申请人提供）：为了响应RFA-HL-12-010， DTMI提议担任肺修复和再生联盟（LRRC）的行政协调中心（ACC）。该提案汇集了一个高素质的个人团队、基础设施和核心资源，以充分支持该联盟推进肺再生和修复研究的目标。我们的ACC领导团队拥有丰富的经验，包括协调和领导多中心研究网络，征求和审查拨款申请，开展教育培训活动，以及在肺生物学和再生方面拥有深入的知识。领导小组由ACC核心资源小组补充，该小组将在生物信息学、生物统计学、研究伦理、知识产权等领域为研究中心（rc）提供科学支持