Lung Repair and Regeneration Consortium Administrative Coordinating Center

描述(由申请人提供)：为响应RFA-HL-12-010，DTMI建议作为肺修复和再生联盟(LRRC)的行政协调中心(ACC)。这项提议汇集了一支由个人、基础设施和核心资源组成的高素质团队，以全力支持该联盟推进肺再生和修复研究的目标。我们的ACC领导团队包括具有丰富经验的人士，他们协调和领导多中心研究网络，征集和审查拨款申请，开展教育培训活动，并拥有肺部生物学和再生方面的深入知识。领导团队由ACC核心资源团队补充，他们将在生物信息学、生物统计学、研究伦理、智力等领域向研究中心(RCS)提供科学支持 财产和监管事务。此外，我们的ACC结构包括一个ACC高级咨询委员会，该委员会由肺生物学、干细胞研究和组织工程方面的成功独立调查人员组成，他们将为ACC提供额外的指导，以确保结构符合LRRC的需求。简而言之，这个领导结构是由了解肺部生物学的复杂性、会说基础研究的语言、并带来丰富的协调多站点网络经验的研究人员组成的。他们将创建一个ACC，促进整个LRRC的沟通，并有效地实现LRRC的所有目标。行政协调会业务小组将由项目领导、网络和通信方面的专门知识组成，并将从技术和预算办公室内部抽调。DTMI内部的这些运营资源在基于网络的网络网站创建、拨款募集和监督以及实习生教育计划的开发方面都有良好的记录，其中包括杜克大学和美国国立卫生研究院共同教授的临床研究硕士课程。总而言之，作为行政协调会，DTMI将促进创新、精简和非常成功的方法来进行研究协调、研究分奖管理和基于网络的沟通。为了实现这些目标，我们为这个联合体制定了三个具体目标：1)组织和进行联盟沟通，包括电话会议、面对面会议，并为RRC创建一个基于网络的虚拟之家，以协同所有网络功能；2)为RCS的合作研究和工具开发项目征集和管理奖项；以及3)支持SDC和SDC委员会的发展，以培训肺再生和修复方面的下一代研究人员。相关性(参见说明)：加强对肺再生和修复的了解对于开发治疗COPD、IPF和其他严重肺部疾病的改进方法至关重要。ACC将促进RCS之间的协作、协同和技能培训共享，并极大地促进对肺干细胞生物学以及调节肺再生和修复的过程的了解。来自lrrc的发现有可能改进肺部疾病的治疗。

DESCRIPTION (provided by applicant): In response to RFA-HL-12-010, the DTMI proposes to serve as the Administrative Coordinating Center (ACC) for the Lung Repair and Regeneration Consortium (LRRC). This proposal brings together a highly qualified team of individuals, infrastructure, and core resources to fully support the goals of the consortium to advance lung regeneration and repair research. Our ACC Leadership Team includes well-established individuals who bring considerable experience coordinating and leading multicenter research networks, soliciting and reviewing grant application, developing educational training activities, and who possess in- depth knowledge of lung biology and regeneration. The Leadership Team is complemented by the ACC Core Resources Team who will provide scientific support to the Research Centers (RCs) in the areas of bioinformatics, biostatistics, research ethics, intellectual property, and regulatory affairs. Additionally, our ACC structure includes an ACC Senior Advisory Committee comprised of successful independent investigators in lung biology, stem cell research, and tissue engineering who will provide additional guidance to the ACC to ensure a structure that meets the needs of the LRRC. In short, this leadership structure is made up of investigators who understand the complexity of lung biology, can speak the language of basic research, and bring a wealth of experience coordinating multisite networks. They will create an ACC that facilitates communication throughout the LRRC and efficiently accomplish all of the LRRC goals. The ACC Operational Team will consist of project leadership, web and communications expertise, and will be drawn from within the DTMI. These operational resources from within the DTMI have a proven record of web-based network website creation, grant solicitation and oversight, and the development of trainee education programs including a Master's program in Clinical Research co-taught at Duke and the NIH. In summary, the DTMI will foster innovative, streamlined, and highly successful approaches to study coordination, research sub award administration, and web-based communication as the ACC. In order to accomplish these goals, we have developed three specific aims for this consortium: 1) To organize and conduct consortium communication, including teleconferences, in-person meetings, and creation of a web-based, virtual home for the LRRC that synergizes all network functions, 2) To solicit and administer awards to the RCs for collaborative research and tool development projects, and 3) To support the development of the SDC and SDC committee to train a future generation of researchers in lung regeneration and repair. RELEVANCE (See instructions): Enhanced understanding of lung regeneration and repair is critical to develop improved approaches to treat COPD, IPF, and other serious lung disorders. The ACC will facilitate the collaboration, synergy, and sharing of skills training among the RCs, and greatly accelerate the understanding of lung stem cell biology and the processes which regulate lung regeneration and repair. The findings from the LRRC have the potential to improve treatments of lung diseases.