Lung Repair and Regeneration Consortium Administrative Coordinating Center

肺修复与再生联盟行政协调中心

• 批准号: 8223487
• 负责人: Scott M Palmer
• 金额: $ 93.53万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8223487
• 关键词: Acute Lung Injury; Advisory Committees; Affect; Applications Grants; Area; Award; Basic Science; Bioinformatics; Biology; Biometry; Chronic Obstructive Airway Disease; Clinical Research; Collaborations; Communication; Complement; Custom; Development; Education; Educational process of instructing; Electronic Mail; Ensure; Face; Fostering; Funding; Future; Future Generations; Goals; Grant; Grant Review; Growth; Guidelines; Hamman-Rich syndrome; Hand; Home environment; Human Resources; Individual; Industry; Information Technology; Institutes; Instruction; Intellectual Property; Investigation; Knowledge; Language; Lead; Leadership; Lung; Lung diseases; Mentors; Modeling; Monitor; National Heart, Lung, and Blood Institute; Natural regeneration; Online Systems; Patients; Peer Review; Persons; Physicians; Pilot Projects; Principal Investigator; Process; Pulmonology; Qualifying; Reagent; Regenerative Medicine; Regulatory Affairs; Reporting; Research; Research Activity; Research Ethics; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Role; Science; Site; Stem Cell Research; Structure; Teleconferences; Testing; Tissue Engineering; Training; Training Activity; Training and Infrastructure; Translational Research; United States National Institutes of Health; Update; Vision; Web communication; career; design; effective therapy; experience; improved; injury and repair; innovation; lung injury; lung repair; meetings; member; multidisciplinary; novel; programs; repaired; research and development; response; skills; skills training; stem; stem cell biology; success; tool; tool development; translational medicine; virtual; web site

DESCRIPTION (provided by applicant): In response to RFA-HL-12-010, the DTMI proposes to serve as the Administrative Coordinating Center (ACC) for the Lung Repair and Regeneration Consortium (LRRC). This proposal brings together a highly qualified team of individuals, infrastructure, and core resources to fully support the goals of the consortium to advance lung regeneration and repair research. Our ACC Leadership Team includes well-established individuals who bring considerable experience coordinating and leading multicenter research networks, soliciting and reviewing grant application, developing educational training activities, and who possess in- depth knowledge of lung biology and regeneration. The Leadership Team is complemented by the ACC Core Resources Team who will provide scientific support to the Research Centers (RCs) in the areas of bioinformatics, biostatistics, research ethics, intellectual property, and regulatory affairs. Additionally, our ACC structure includes an ACC Senior Advisory Committee comprised of successful independent investigators in lung biology, stem cell research, and tissue engineering who will provide additional guidance to the ACC to ensure a structure that meets the needs of the LRRC. In short, this leadership structure is made up of investigators who understand the complexity of lung biology, can speak the language of basic research, and bring a wealth of experience coordinating multisite networks. They will create an ACC that facilitates communication throughout the LRRC and efficiently accomplish all of the LRRC goals. The ACC Operational Team will consist of project leadership, web and communications expertise, and will be drawn from within the DTMI. These operational resources from within the DTMI have a proven record of web-based network website creation, grant solicitation and oversight, and the development of trainee education programs including a Master's program in Clinical Research co-taught at Duke and the NIH. In summary, the DTMI will foster innovative, streamlined, and highly successful approaches to study coordination, research sub award administration, and web-based communication as the ACC. In order to accomplish these goals, we have developed three specific aims for this consortium: 1) To organize and conduct consortium communication, including teleconferences, in-person meetings, and creation of a web-based, virtual home for the LRRC that synergizes all network functions, 2) To solicit and administer awards to the RCs for collaborative research and tool development projects, and 3) To support the development of the SDC and SDC committee to train a future generation of researchers in lung regeneration and repair. RELEVANCE (See instructions): Enhanced understanding of lung regeneration and repair is critical to develop improved approaches to treat COPD, IPF, and other serious lung disorders. The ACC will facilitate the collaboration, synergy, and sharing of skills training among the RCs, and greatly accelerate the understanding of lung stem cell biology and the processes which regulate lung regeneration and repair. The findings from the LRRC have the potential to improve treatments of lung diseases.

描述（由申请人提供）：为响应RFA-HL-12-010，DTMI提议担任肺修复和再生联盟（LRRC）的行政协调中心（ACC）。该提案汇集了一个由个人、基础设施和核心资源组成的高素质团队，以充分支持该联盟推进肺再生和修复研究的目标。我们的ACC领导团队包括具有丰富经验的个人，他们协调和领导多中心研究网络，征求和审查资助申请，开发教育培训活动，并拥有深入的肺生物学和再生知识。ACC核心资源团队将在生物信息学、生物统计学、研究伦理学、知识产权、生物技术和生物技术领域为研究中心（RC）提供科学支持。 财产和监管事务。此外，我们的ACC结构包括一个ACC高级咨询委员会，由肺生物学，干细胞研究和组织工程领域的成功独立研究人员组成，他们将为ACC提供额外的指导，以确保结构满足LRRC的需求。简而言之，这个领导结构由了解肺部生物学复杂性、能够说基础研究语言并带来协调多地点网络的丰富经验的研究人员组成。他们将创建一个ACC，促进整个LRRC的通信，并有效地实现所有LRRC的目标。行政协调会业务小组将由项目领导、网络和通信专门知识组成，并将从国防技术研究所内部抽调人员。DTMI内部的这些运营资源在基于Web的网络网站创建、资助征集和监督以及培训生教育计划的开发方面拥有良好的记录，其中包括在杜克和NIH共同教授的临床研究硕士课程。总而言之，DTMI将促进创新，精简，和非常成功的方法来研究协调，研究子奖项管理和基于网络的交流作为ACC。为了实现这些目标，我们为这个联盟制定了三个具体目标：1）组织和进行联合体沟通，包括电话会议，面对面会议，以及创建基于网络的，LRRC的虚拟主页，协同所有网络功能，2）征求和管理对RC的合作研究和工具开发项目的奖励，以及3）支持SDC和SDC委员会的发展，以培训下一代肺再生和修复研究人员。相关性（参见说明）：增强对肺再生和修复的理解对于开发治疗COPD、IPF和其他严重肺部疾病的改进方法至关重要。ACC将促进RC之间的协作、协同作用和技能培训共享，并大大加快对肺干细胞生物学以及调节肺再生和修复过程的理解。LRRC的发现有可能改善肺部疾病的治疗。