Lung Repair and Regeneration Consortium Administrative Coordinating Center

针对RFA-HL-12-010，DTMI建议担任行政协调中心 (ACC)用于肺修复和再生联盟(LRRC)。这项建议汇集了一个高度 由合格的个人、基础设施和核心资源组成的团队，以全面支持财团的目标 推进肺再生与修复研究。我们的ACC领导团队包括久负盛名的 具有协调和领导多中心研究网络的丰富经验的个人， 征集和审查赠款申请，开展教育培训活动，以及谁拥有- 对肺部生物学和再生有深入的了解。领导团队得到行政协调会核心的补充 将在以下领域向研究中心(RCS)提供科学支持的资源团队 生物信息学、生物统计学、研究伦理、知识产权和监管事务。此外，我们的 行政协调会的结构包括一个行政协调会高级咨询委员会，该委员会由成功的独立 肺生物学、干细胞研究和组织工程方面的研究人员将提供更多指导 向行政协调委员会提交报告，以确保其结构符合土地资源报告委员会的需要。简而言之，这种领导结构是 由了解肺部生物学复杂性的调查人员组成，能说基本的语言 研究，并带来丰富的协调多站点网络的经验。他们将创建一个ACC， 促进整个LRRC的沟通，并有效地实现LRRC的所有目标。访问权限 运营团队将由项目领导、网络和通信专业知识组成，并将被抽调 从DTMI内部。DTMI内部的这些运营资源具有基于Web的已证明的记录 网络网站的创建、赠款征集和监督以及学员教育的发展 包括临床研究硕士项目在内的课程在杜克大学和美国国立卫生研究院共同教授。总而言之， DTMI将促进创新、精简和非常成功的方法来研究协调， 研究分奖管理，以及作为ACC的基于网络的交流。为了实现这些目标 目标，我们为这个联合体制定了三个具体目标：1)组织和开展联合体 通信，包括电话会议、面对面会议和创建基于网络的虚拟家庭 为协调所有网络功能的资源中心，2)向资源中心征集和管理奖项 合作研究和工具开发项目；以及3)支持开发可持续发展战略和 SDC委员会将培训肺再生和修复方面的下一代研究人员。

In response to RFA-HL-12-010, the DTMI proposes to serve as the Administrative Coordinating Center (ACC) for the Lung Repair and Regeneration Consortium (LRRC). This proposal brings together a highly qualified team of individuals, infrastructure, and core resources to fully support the goals of the consortium to advance lung regeneration and repair research. Our ACC Leadership Team includes well-established individuals who bring considerable experience coordinating and leading multicenter research networks, soliciting and reviewing grant application, developing educational training activities, and who possess in- depth knowledge of lung biology and regeneration. The Leadership Team is complemented by the ACC Core Resources Team who will provide scientific support to the Research Centers (RCs) in the areas of bioinformatics, biostatistics, research ethics, intellectual property, and regulatory affairs. Additionally, our ACC structure includes an ACC Senior Advisory Committee comprised of successful independent investigators in lung biology, stem cell research, and tissue engineering who will provide additional guidance to the ACC to ensure a structure that meets the needs of the LRRC. In short, this leadership structure is made up of investigators who understand the complexity of lung biology, can speak the language of basic research, and bring a wealth of experience coordinating multisite networks. They will create an ACC that facilitates communication throughout the LRRC and efficiently accomplish all of the LRRC goals. The ACC Operational Team will consist of project leadership, web and communications expertise, and will be drawn from within the DTMI. These operational resources from within the DTMI have a proven record of web-based network website creation, grant solicitation and oversight, and the development of trainee education programs including a Master's program in Clinical Research co-taught at Duke and the NIH. In summary, the DTMI will foster innovative, streamlined, and highly successful approaches to study coordination, research subaward administration, and web-based communication as the ACC. In order to accomplish these goals, we have developed three specific aims for this consortium: 1) To organize and conduct consortium communication, including teleconferences, in-person meetings, and creation of a web-based, virtual home for the LRRC that synergizes all network functions, 2) To solicit and administer awards to the RCs for collaborative research and tool development projects, and 3) To support the development ofthe SDC and SDC committee to train a future generation of researchers in lung regeneration and repair.