Thomas L. Petty Conference: Mechanics and Mechanisms of Pulmonary Hypertension

简介(申请人提供)：第55届Thomas L.Petty Aspen肺会议的主题是“肺动脉高压的力学和机制”。重点将放在肺血管疾病和肺血管-右室轴领域的基础科学、转化科学和临床科学的整合上。将在确定疾病发病机制中的机制事件的同时，探索肺动脉高压的临床影响。主题会议将以12个“最先进的”报告为基础，讨论遗传易感性和流行病学、肺血管干和祖细胞生物学、右室衰竭和右室-肺动脉偶联的作用、基因突变、表观遗传学、全身炎症、新的靶向治疗和疾病改良干预措施。这一重点与NHLBI最近为解决肺动脉高压和右室衰竭/功能障碍的机制所做的努力是一致的。会议纪要将由吉森大学医院内科主任、医学教授Werner Seeger介绍。西格博士担任肺中心主席和马克斯·普朗克心肺研究所所长，是国际公认的肺血管疾病领域的专家。会议的主要目的是：1)为基础和临床研究人员提供一个交流有关肺血管和右室疾病的想法的国际论坛；2)鼓励和发展对知识快速发展的领域的参与，通过介绍和与知名专家合作，促进初级研究人员进入该领域；3)为与会者提供机会，通过与国际公认的临床医生和研究人员的审查和讨论，深入关注一个主题；以及4)推动肺部医学的进一步研究。

DESCRIPTION (provided by applicant): The theme of the 55th Annual Thomas L. Petty Aspen Lung Conference is "Mechanics and Mechanisms of Pulmonary Hypertension". The emphasis will be on the integration of basic, translational and clinical sciences in the area of pulmonary vascular disease and pulmonary vascular-right ventricular axis. The clinical impact of pulmonary hypertension will be explored while identifying the mechanistic events in the disease's pathogenesis. Anchored by twelve "state-of-the-art" presentations, thematic sessions will address genetic susceptibility and epidemiology, pulmonary vascular stem and progenitor cell biology, role of the right ventricle failure and right ventricular-pulmonary artery coupling, genetic mutations, epigenetics, systemic inflammation, novel targeted therapies, and disease modifying interventions. This focus is in line with the recent effort by the NHLBI to address the mechanisms underlying both pulmonary hypertension and right ventricular failure/dysfunction. The Conference Summary will be presented by Werner Seeger, M.D., Professor of Medicine, Chief of the Department of Internal Medicine at the University of Giessen Hospital. Dr Seeger serves as chairman of the Lung Center, and Director of the Max Planck Institute for Heart and Lung Research and is an internationally recognized expert in the field of pulmonary vascular disease. The main objectives of the conference are to 1) provide an international forum for basic and clinical researchers to exchange ideas relating to pulmonary vascular and right ventricular disease; 2) encourage and develop participation in a field where knowledge is rapidly advancing, facilitating entry of junior investigators into the arena via introduction and collaboration with established experts; 3) provide an opportunity for participants to focus in depth on a single topic by review and discussion with internationally recognized clinicians and researchers; and 4) provide an impetus to further research in pulmonary medicine.