SUPPORT FOR NATIONAL PRIMATE RESEARCH CENTER

补助金P51 RR00163-50的5年续期要求为ONPRC的项目提供资金，这些项目支持 生物医学研究。该应用反映了跨学科研究的新战略重点，以优化 非人灵长类(NHP)模型的使用和发展。本申请的目的是：1)提供 进行先进的生物医学研究所需的基础设施支持，而NHP被用于 加快了解人类疾病的进展；2)加强中心的资源(科学资源 专业知识、实验室、动物服务、研究支持核心和设备)，以作为区域 和国家资源；3)通过支持增加用于生物医学研究的已确定的NHP的可用性 我们扩大SPF印度原种恒河猴繁育计划的计划；以及4)扩大 利用NHP在干细胞生物学、衰老、肥胖症、遗传学、传染病、疫苗等领域的研究计划 发展、神经科学和妇女健康。为了实现这些目标，需要在三个方面提供支持 广阔的区域。首先，行政和中心运营提供行政和服务支持 ONPRC的所有方面都需要。单位包括：1)主任办公室；2)行政事务 (商业服务、环境健康及辐射安全、设施及物业、资讯科技 3)动物资源(管理、操作、行为 服务、病理服务、外科服务和临床医学)；以及4)研究支持核心 (辅助生殖技术、内分泌技术、成像与形态学、免疫学、磁学 共振成像、分子和细胞生物学、病毒学和血清学)。第二，科学 构成部分包括支持：1)科学部(神经科学、病理生物学和免疫学以及 生殖科学)及其跨学科工作组(衰老生物学、代谢性疾病、 和干细胞与发育生物学)；2)促进外部资助的合作研究单位 研究；3)试点项目计划；4)资源相关研究。最后，改进和改进 现代化包括设备以及改建和翻新的资金。

The 5-year renewal for Grant P51 RR00163-50 requests funding for programs at the ONPRC that support biomedical research. The application reflects a new strategic focus on interdisciplinary research to optimize the use and development of nonhuman primate (NHP) models. The aims of this application are to: 1) provide the infrastructure support necessary to conduct advanced biomedical research for which NHPs are used to accelerate progress in understanding human diseases; 2) enhance the Center's resources (scientific expertise, laboratories, animal services, research support cores and equipment) so as to serve as a regional and national resource; 3) increase the availability of defined NHPs for biomedical research through support of our programs to expand the SPF Indian-origin rhesus macaque breeding program; and 4) expand research programs utilizing NHPs in stem cell biology, aging, obesity, genetics, infectious diseases, vaccine development, neuroscience and women's health. To accomplish these aims, support is requested in three broad areas. First, Administration & Center Operations provide the administrative and service support required for all aspects of the ONPRC. Units include: 1) the Director's Office; 2) Administrative Services (Business Services, Environmental Health & Radiation Safety, Facilities & Property, Information Technology & Engineering, and the Research Library); 3) Animal Resources (Administration, Operations, Behavioral Services, Pathology Services, Surgery Services, and Clinical Medicine); and 4) Research Support Cores (Assisted Reproductive Technology, Endocrine Technology, Imaging & Morphology, Immunology, Magnetic Resonance Imaging, Molecular & Cellular Biology, and Virology & Serology). Secondy, Scientific Components include support for: 1) Scientific Divisions (Neuroscience, Pathobiology & Immunology, and Reproductive Sciences) and their interdisciplinary Working Groups (Biology of Aging, Metabolic Disease, and Stem Cell & Developmental Biology); 2) the Collaborative Research Unit that facilitates externallyfunded research; 3) the Pilot Project Program; and 4) Resource-Related Research. Finally, Improvement & Modernization includes funds for equipment and alterations and renovations.