SUPPORT FOR NATIONAL PRIMATE RESEARCH CENTER

支持国家灵长类研究中心

• 批准号: 7472670
• 负责人: JOSEPH E ROBERTSON
• 金额: $ 79.92万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7472670
• 关键词: SUPPORT; NATIONAL; PRIMATE; RESEARCH; CENTER

DESCRIPTION (provided by applicant): The 5-year renewal for Grant P51 RR00163-45 requests funding for programs that support biomedical research at the ONPRC. The application reflects a significant expansion in animal resources and research service cores that is required to support the growth in research programs (external grant funding has doubled during the past 5 years) and to greatly expand the Specific Pathogen Free (SPF) Indian-derived Rhesus Breeding Colony. The aims of this application are to: 1) provide the infrastructure support necessary to conduct advanced biomedical research for which nonhuman primates (NHPs) are used to accelerate progress in understanding human diseases, leading to better health; 2) enhance the Center's resources (scientific expertise, laboratories, animal services, research service cores and equipment) so as to serve as a regional, national and international resource; 3) increase the availability of defined NHPs for biomedical research through support of our programs to expand the SPF Indian-derived Rhesus macaque breeding program that produces animals free of viruses such as herpes B and with defined parentage and genotype; and 4) expand research programs utilizing NHPs in genetics, infectious diseases and vaccine development, aging, neuroscience and women's health. To accomplish these aims, support is requested in four broad areas. Administration and Center Operations provide the administrative and service support that is required for all aspects of the ONPRC. Units include the Director's Office, Business Services, Facilities and Property, and Information Technology and Engineering. Research Infrastructure encompasses the service units that provide the most technologically advanced research support, such as Animal Resources (Business and Research Coordination, Clinical Medicine, NHP Resources, Operations, Pathology Services, Psychological Well Being and Surgery Services), Research Service Cores (Assisted Reproductive Technology, Electrophysiology, Endocrine Services, Flow Cytometry, Imaging and Morphology, Molecular and Cellular Biology, Monoclonal Antibody, Research Library, and Virology) and Special Resources Programs (Alternative NHP Species, Genetics Resource and Informatics, Aging NHPs and Rhesus Breeding). Scientific Resources includes support for the three research divisions that house ONPRC scientists: the Divisions of Pathobiology and Immunology, Neuroscience, and Reproductive Sciences. Funding is also requested for 4 resource-related research projects and the pilot project program. Improvement and Modernization includes funds for equipment and alterations and renovations. The funds requested will provide support for the research infrastructure that is required to conduct the most advanced biomedical research using NHPs as models of human health and disease, and to meet the needs of new emerging areas of research in which the NHP model is critical, such as functional genomics and biodefense initiatives.

描述（由申请人提供）：P51 RR00163-45 拨款的 5 年续展请求为支持 ONPRC 生物医学研究的项目提供资金。该申请反映了动物资源和研究服务核心的显着扩大，这是支持研究项目增长所需的（外部拨款资金在过去 5 年内翻了一番），并大大扩大了无特定病原体 (SPF) 印度恒河猴育种群体。 该应用程序的目的是：1) 提供进行先进生物医学研究所需的基础设施支持，利用非人类灵长类动物 (NHP) 来加速了解人类疾病的进展，从而改善健康状况； 2) 增强中心的资源（科学专业知识、实验室、动物服务、研究服务核心和设备），使其成为区域、国家和国际资源； 3) 通过支持我们扩大 SPF 印度恒河猴育种计划的计划，增加用于生物医学研究的确定的 NHP 的可用性，该计划生产出没有 B 型疱疹等病毒且具有确定的亲本和基因型的动物； 4) 扩大利用 NHP 在遗传学、传染病和疫苗开发、老龄化、神经科学和妇女健康方面的研究项目。为了实现这些目标，需要在四个广泛领域提供支持。行政和中心运营提供 ONPRC 各方面所需的行政和服务支持。部门包括主任办公室、商业服务、设施和财产以及信息技术和工程。研究基础设施包括提供技术最先进的研究支持的服务单位，例如动物资源（业务和研究协调、临床医学、NHP资源、运营、病理学服务、心理健康和手术服务）、研究服务核心（辅助生殖技术、电生理学、内分泌服务、流式细胞术、成像和形态学、分子和细胞生物学、单克隆抗体、 研究图书馆和病毒学）和特殊资源计划（替代 NHP 物种、遗传资源和信息学、老龄化 NHP 和恒河猴育种）。科学资源包括对 ONPRC 科学家所在的三个研究部门的支持：病理生物学和免疫学部门、神经科学部门和生殖科学部门。还要求为 4 个与资源相关的研究项目和试点项目计划提供资金。改进和现代化包括设备、改建和翻新资金。所申请的资金将为研究基础设施提供支持，这些基础设施是使用 NHP 作为人类健康和疾病模型进行最先进的生物医学研究所需的，并满足 NHP 模型至关重要的新兴研究领域的需求，例如功能基因组学和生物防御计划。