Frontotemporal Neural Systems in Biopolar Disorder and Schizophrenia

双相情感障碍和精神分裂症的额颞神经系统

• 批准号: 8309368
• 负责人: Fei Wang
• 金额: $ 17.83万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8309368
• 关键词: Address; Amygdaloid structure; Area; Bipolar Disorder; Brain; Clinical; Collaborations; Data; Development; Disease; Dorsal; Emotional; ErbB4 gene; Face; Genes; Genetic Variation; Goals; Hippocampus (Brain); Individual; Instruction; Interdisciplinary Study; K-Series Research Career Programs; Lateral; Mentors; Mentorship; Molecular Genetics; Molecular Models; Nature; Neuregulin 1; Neurosciences; Participant; Predisposition; Prefrontal Cortex; Relative (related person); Research; Research Methodology; Research Personnel; Research Technics; Schizophrenia; Science; Stimulus; Structure; System; Techniques; Training; Training Support; Work; effective therapy; emotional stimulus; investigator training; molecular modeling; multidisciplinary; neuroimaging; novel; receptor; relating to nervous system; response

The goal of this Mentored Career Development Award proposal is to provide Dr. Fei Wang advanced training in integrating multidisciplinary research methods, including multimodal neuroimaging techniques and molecular genetics, to study the frontotemporal neural system involved in bipolar disorder (BD) and schizophrenia (SZ). Dr. Wang's rich background implementing multimodal neuroimaging techniques and molecular genetics in the study of BD and SZ makes her uniquely suited to conduct this work. Utilizing the aforementioned techniques, she proposes to conduct direct comparisons between individuals with BD, SZ and healthy comparison participants necessary to elucidate the distinct pathophyisology involved in each disorder. Emerging data in BD and SZ simultaneously support overlapping susceptibility to genes that regulate the development of frontotemporal neural systems as well as features offrontotemporalabnormalities that are distinct to each disorder. Frontotemporal neural system abnormalities in BD are centered in more ventral structures including ventral prefrontal cortex and amygdala; while deficits in more dorsal areas are implicated in SZ including dorsal lateral prefrontal cortex and the hippocampus. Furthermore, she will investigate the differential impact of genetic variation in neuregulin 1 and its receptor ErbB4 on the frontotemporal neural systems in BD and SZ. Training components will include supervised research, formal coursework, and advanced training in multimodal neuroimaging techniques and molecular genetics. The multidisciplinary nature of this project, conducted under the mentorship of Drs. Hilary Blumberg, John Krystal, R. Todd Constable and Joel Gelernter, in collaboration with experts in BD and SZ research, neuroimaging analysis, molecular genetics, molecular modeling strategies for neuroimaging studies and clinical neuroscience will provide a valuable opportunity for the candidate to address issues regarding the effects of genetic variation on the frontotemporal neural systems in BD and SZ. The project will provide the vital support and training necessary for Dr. Wang to become an independent investigator expert in the application of multimodal neuroimaging and molecular genetics to identify underlying frontotemporal neural system abnormalities in BD and SZ. RELEVANCE (See instructions): This project aims to investigate differences in the distribution of brain abnormalities in bipolar disorder and schizophrenia and to determine which genes may contribute to the distinct distributions. This work will enhance our understanding of the causes of these disorders, our ability to detect the disorders early and to develop novel and more effective treatments. Finally, it will enable the training of an investigator uniquely suited to conduct this work by combining advanced research techniques from various fields of science.

这个指导职业发展奖提案的目标是为王飞博士提供高级培训， 整合多学科研究方法，包括多模态神经成像技术和分子生物学技术。 遗传学，研究额颞叶神经系统参与双相情感障碍（BD）和精神分裂症（SZ）。 博士Wang丰富的背景实施多模态神经成像技术和分子遗传学， 对BD和SZ的研究使她特别适合进行这项工作。利用上述技术，她 建议在BD、SZ个体和健康对照参与者之间进行直接比较 阐明每种疾病所涉及的不同病理生理学是必要的。BD和SZ的新兴数据 同时支持对调节额颞神经发育的基因的重叠易感性， 系统以及特征的额颞叶异常是不同的每一个障碍。额颞 BD的神经系统异常集中在更腹侧的结构，包括腹侧前额叶皮质， 杏仁核;而更多背侧区域的缺陷与SZ有关，包括背外侧前额叶皮层和 海马体此外，她将研究neuregulin 1基因变异的差异影响， 其受体ErbB 4在BD和SZ的额颞神经系统上的表达。培训内容将包括 监督研究，正式的课程，以及多模式神经成像技术的高级培训， 分子遗传学该项目的多学科性质，在希拉里博士的指导下进行 放大图片创作者：John Krystal，R.托德康斯特布尔和乔尔格勒恩特，与BD和SZ的专家合作 研究，神经影像学分析，分子遗传学，神经影像学研究的分子建模策略， 临床神经科学将为候选人提供一个宝贵的机会，以解决有关影响的问题， BD和SZ额颞神经系统的遗传变异。该项目将提供重要的支持， 王博士成为独立研究专家所需的培训， 多模式神经影像学和分子遗传学，以确定潜在的额颞神经系统 BD和SZ的异常。 相关性（参见说明）： 该项目旨在研究双相情感障碍患者大脑异常分布的差异， 精神分裂症，并确定哪些基因可能有助于不同的分布。这项工作将 提高我们对这些疾病的原因的理解，我们早期发现这些疾病的能力， 开发新的更有效的治疗方法。最后，它将使调查员的培训具有独特性， 适合通过结合来自各个科学领域的先进研究技术来进行这项工作。