Frontotemporal Neural Systems in Biopolar Disorder and Schizophrenia

双相情感障碍和精神分裂症的额颞神经系统

• 批准号: 8469910
• 负责人: Fei Wang
• 金额: $ 17.7万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8469910
• 关键词: Address; Amygdaloid structure; Area; Bipolar Disorder; Brain; Clinical; Collaborations; Data; Development; Disease; Dorsal; Emotional; ErbB4 gene; Face; Genes; Genetic Variation; Goals; Hippocampus (Brain); Individual; Instruction; Interdisciplinary Study; K-Series Research Career Programs; Lateral; Mentors; Mentorship; Molecular Genetics; Molecular Models; Nature; Neuregulin 1; Neurosciences; Participant; Predisposition; Prefrontal Cortex; Relative (related person); Research; Research Methodology; Research Personnel; Research Technics; Schizophrenia; Science; Stimulus; Structure; System; Techniques; Training; Training Support; Work; effective therapy; emotional stimulus; investigator training; molecular modeling; multidisciplinary; neuroimaging; novel; receptor; relating to nervous system; response

The goal of this Mentored Career Development Award proposal is to provide Dr. Fei Wang advanced training in integrating multidisciplinary research methods, including multimodal neuroimaging techniques and molecular genetics, to study the frontotemporal neural system involved in bipolar disorder (BD) and schizophrenia (SZ). Dr. Wang's rich background implementing multimodal neuroimaging techniques and molecular genetics in the study of BD and SZ makes her uniquely suited to conduct this work. Utilizing the aforementioned techniques, she proposes to conduct direct comparisons between individuals with BD, SZ and healthy comparison participants necessary to elucidate the distinct pathophyisology involved in each disorder. Emerging data in BD and SZ simultaneously support overlapping susceptibility to genes that regulate the development of frontotemporal neural systems as well as features offrontotemporalabnormalities that are distinct to each disorder. Frontotemporal neural system abnormalities in BD are centered in more ventral structures including ventral prefrontal cortex and amygdala; while deficits in more dorsal areas are implicated in SZ including dorsal lateral prefrontal cortex and the hippocampus. Furthermore, she will investigate the differential impact of genetic variation in neuregulin 1 and its receptor ErbB4 on the frontotemporal neural systems in BD and SZ. Training components will include supervised research, formal coursework, and advanced training in multimodal neuroimaging techniques and molecular genetics. The multidisciplinary nature of this project, conducted under the mentorship of Drs. Hilary Blumberg, John Krystal, R. Todd Constable and Joel Gelernter, in collaboration with experts in BD and SZ research, neuroimaging analysis, molecular genetics, molecular modeling strategies for neuroimaging studies and clinical neuroscience will provide a valuable opportunity for the candidate to address issues regarding the effects of genetic variation on the frontotemporal neural systems in BD and SZ. The project will provide the vital support and training necessary for Dr. Wang to become an independent investigator expert in the application of multimodal neuroimaging and molecular genetics to identify underlying frontotemporal neural system abnormalities in BD and SZ. RELEVANCE (See instructions): This project aims to investigate differences in the distribution of brain abnormalities in bipolar disorder and schizophrenia and to determine which genes may contribute to the distinct distributions. This work will enhance our understanding of the causes of these disorders, our ability to detect the disorders early and to develop novel and more effective treatments. Finally, it will enable the training of an investigator uniquely suited to conduct this work by combining advanced research techniques from various fields of science.

这项导师职业发展奖提案的目标是为王飞博士提供 整合多学科研究方法，包括多模式神经成像技术和分子 遗传学，研究双相情感障碍(BD)和精神分裂症(SZ)所涉及的额颞叶神经系统。 王博士在实施多模式神经成像技术和分子遗传学方面的丰富背景 对BD和SZ的研究使她成为唯一适合从事这项工作的人。利用前面提到的技术，她 建议在患有BD、SZ的个体与健康对照参与者之间进行直接比较 有必要阐明每种疾病涉及的不同病理生理学。BD和SZ的新兴数据 同时支持对调控额颞神经发育的基因的重叠易感性 系统以及与每种疾病截然不同的临时性异常的特征。额颞部 BD的神经系统异常集中在更多的腹侧结构，包括腹侧前额叶皮质和 杏仁核；而更多背侧区域的缺陷与SZ有关，包括背侧外侧前额叶皮质和 海马体。此外，她还将研究神经调节蛋白1和神经调节蛋白基因变异的不同影响。 其受体ErbB4在BD和SZ的额颞叶神经系统中的表达。培训部分将包括 多模式神经成像技术和技术方面的监督研究、正式课程和高级培训 分子遗传学。这个项目的多学科性质，在希拉里博士的指导下进行 首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细文摘内容 研究，神经成像分析，分子遗传学，神经成像研究的分子建模策略和 临床神经科学将为应聘者提供一个宝贵的机会来解决有关影响的问题 BD和SZ额颞神经系统的遗传变异。该项目将提供至关重要的支持 以及王博士成为独立调查专家所需的培训 多模式神经成像和分子遗传学用于识别潜在的额颞部神经系统 BD和SZ的异常。 相关性(请参阅说明)： 本项目旨在研究双相情感障碍患者脑部异常分布的差异。 并确定哪些基因可能对不同的分布起作用。这项工作将 增强我们对这些疾病的原因的了解，我们及早发现这些疾病并 开发新的、更有效的治疗方法。最后，它将使调查人员的培训具有独特性 适合通过结合不同科学领域的先进研究技术来进行这项工作的。

项目成果

Changes in cerebellar functional connectivity and anatomical connectivity in schizophrenia: a combined resting-state functional MRI and diffusion tensor imaging study.

精神分裂症中小脑功能连接和解剖连接的变化：静息态功能 MRI 和弥散张量成像相结合的研究。

• DOI: 10.1002/jmri.22784
• 发表时间: 2011-12
• 期刊: JOURNAL OF MAGNETIC RESONANCE IMAGING
• 影响因子: 4.4
• 作者: Liu, Hu;Fan, Guoguang;Xu, Ke;Wang, Fei
• 通讯作者: Wang, Fei

Differentiating patterns of amygdala-frontal functional connectivity in schizophrenia and bipolar disorder.

精神分裂症和双相情感障碍中杏仁核-额叶功能连接的区分模式

• DOI: 10.1093/schbul/sbt044
• 发表时间: 2014-03
• 期刊: Schizophrenia bulletin
• 影响因子: 6.6
• 作者: Liu H;Tang Y;Womer F;Fan G;Lu T;Driesen N;Ren L;Wang Y;He Y;Blumberg HP;Xu K;Wang F
• 通讯作者: Wang F

Voxel-Based Morphometry in Individuals at Genetic High Risk for Schizophrenia and Patients with Schizophrenia during Their First Episode of Psychosis.

• DOI: 10.1371/journal.pone.0163749
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Chang M;Womer FY;Bai C;Zhou Q;Wei S;Jiang X;Geng H;Zhou Y;Tang Y;Wang F
• 通讯作者: Wang F

Impaired interhemispheric connectivity in medication-naive patients with major depressive disorder.

• DOI: 10.1503/jpn.110132
• 发表时间: 2013
• 期刊: Journal of psychiatry & neuroscience : JPN
• 作者: Ke Xu;Wenyan Jiang;Ling Ren;Ouyang Xuan;Yifeng Jiang;Feng Wu;Ling-tao Kong;F. Womer;Zhening Liu;H. Blumberg;Yanqing Tang;Fei Wang

Whiter matter abnormalities in medication-naive subjects with a single short-duration episode of major depressive disorder.

曾接受过一次短期重度抑郁症发作的初治受试者的白质异常

• DOI: 10.1016/j.pscychresns.2010.09.002
• 发表时间: 2011-01-30
• 期刊: PSYCHIATRY RESEARCH-NEUROIMAGING
• 影响因子: 2.3
• 作者: Wu, Feng;Tang, Yanqing;Xu, Ke;Kong, Lingtao;Sun, Wenge;Wang, Fei;Kong, Dongyan;Li, Yanliang;Liu, Ying
• 通讯作者: Liu, Ying