Culturally Relevant HIV Prevention for High-Risk Women

变性妇女(出生时被指定为男性，身份为女性)是一个未被充分研究的艾滋病毒携带者群体 患病率在22%至68%之间。公共卫生干预研究还没有产生任何理论- 为变性妇女提供以证据为基础的驱动型干预措施。变性人独特的文化语境 女性创造了不同的风险因素，需要系统的调查，然后融入文化 以社区为基础的干预方法。这个K08应用程序描述了一个全面的、 综合培训和研究计划，旨在作为实现科学独立和 开发和测试创新和迫切需要的干预措施以改善健康结果的专业知识 在受艾滋病毒流行严重影响的高度边缘化人群中。以下是 提出了培训目标：(1)获得理论评估和应用方面的专业知识 对边缘化人群的行为改变；(2)提高混合方法数据的使用技能 收集和分析，重点是与测量发展和理论相关的技术 (3)获得临床试验方法学方面的知识和经验，包括抽样问题， 随机化、设计、方案制定和伦理；以及(4)在以下方面获得培训和经验 开发、实施和评估以文化为基础、理论驱动的艾滋病毒预防的方法 对变性人妇女的干预。指导原创研究的具体研究目的是：(1) 描述变性人妇女独特的文化背景在其艾滋病毒相关风险和保护方面的作用 因素；(2)创建新的量化措施并调整现有的量化措施，以更准确地评估 与变性妇女艾滋病毒风险和保护因素相关的心理社会维度和行为；(3) 确定与HIV相关的性行为和注射危险行为相关的心理社会因素和防护措施 跨性别女性的因素；以及(4)开发和测试一种理论的可行性和可接受性-- 为跨性别者妇女提供驱动的、基于文化的艾滋病毒预防干预。 相关性(请参阅说明)： 变性人女性(出生时被指定为男性，但自认为是女性)是一个研究不足且高度重视的群体 弱势群体，艾滋病毒流行率在22%至68%之间。由于耻辱和歧视， 他们可能会以增加风险的方式寻求肯定。该项目旨在调查独特的风险因素，以 为这些高危妇女制定具有文化相关性的艾滋病毒预防干预措施。 项目/绩效SIJE(S)(如果需要额外空间，请使用

ransgender women (assigned 'male' at birth with a female identity) are an understudied group with HIV prevalence rates in the range of 22 to 68%. Public health intervention research has produced no theory- driven, evidence-based interventions for transgender women. The unique cultural context of transgender women creates distinct risk factors that require systematic investigation and then integration into culturally elevant, community-based approaches to intervention. This K08 application describes a comprehensive, ntegrated training and research plan designed to serve as a pathway to scientific independence and the expertise to develop and test an innovative and urgently needed intervention to improve health outcomes among a highly marginalized population disproportionately affected by the HIV epidemic. The following raining objectives are proposed: (1) to acquire expertise in the evaluation and application of theories of behavior change to marginalized populations; (2) to enhance skills in the use of mixed methods data collection and analysis, with an emphasis on techniques relevant to measurement development and theory testing; (3) to gain knowledge and experience with clinical trials methodology, including issues of sampling, randomization, design, protocol development, and ethics; and (4) to obtain training and experience in methods for developing, implementing, and evaluating culturally grounded, theory-driven HIV prevention interventions for transgender women. The specific research aims of the mentored original research are: (1) to describe the role of transgender women's unique cultural context on their HIV-related risk and protective factors; (2) to create new and to adapt existing quantitative measures to more accuratelyassess psychosocial dimensions and behavior relevant to transgender women's HIV risk and protective factors; (3) to identify psychosocial factors associatedwith HIV-related sexual and injection risk behaviors and protective factors among transgender women; and (4) to develop and test the feasibility and acceptability of a theory- driven, culturally grounded HIV prevention intervention for transgender women. RELEVANCE (See instructions): Transgender women (assigned 'male' at birth but identify as female) are an understudied and highly vulnerable group, with HIV prevalence rates in the range of 22 to 68%. Due to stigma and discrimination, they may seek affirmation in ways that increase risk. This project seeks to investigate unique risk factors to develop a culturally relevant HIV prevention intervention for these high-risk women. PROJECT/PERFORMANCE SIJE(S) (if additional space is needed, use