Mentoring clinical investigators in patient-oriented research on substance use and HIV

指导临床研究人员进行以患者为导向的药物滥用和艾滋病毒研究

• 批准号: 10653983
• 负责人: Jae M. Sevelius
• 金额: $ 12.51万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10653983
• 关键词: AIDS prevention; Address; Adherence; Alcohols; Area; Behavior; Behavioral; Brazil; California; Caring; Categories; Clinical Investigator; Collaborations; Communities; Complement; Data; Data Analyses; Dedications; Development Plans; Discrimination; Economics; Enrollment; Evaluation; Focus Groups; Funding; Future; Gender; HIV; HIV disparities; HIV prevention trial; HIV risk; Health; Health Personnel; Health Promotion; Health behavior; Healthcare; Individual; Inequality; Infrastructure; Institution; International; Intervention; Intervention Studies; Interview; Investigation; Knowledge; Link; Measurement; Medicine; Mentors; Mentorship; Modeling; Outcome; Participant; Pattern; Persons; Pharmaceutical Preparations; Policy Maker; Population; Property; Race; Randomized, Controlled Trials; Research; Research Activity; Research Personnel; Research Proposals; Research Support; Resources; Risk; Risk Factors; San Francisco; Scholarship; Sex Orientation; Sexual and Gender Minorities; Social Environment; Social Identification; Social Processes; Social status; Testing; Training; United States; Universities; Unsafe Sex; Woman; Work; Writing; career; career development; cohort; community organizations; design; efficacy testing; experience; gender affirmation; gender diversity; health disparity; implementation evaluation; implementation science; implementation study; improved; informant; innovation; insight; intersectionality; marginalization; mid-career faculty; multidisciplinary; novel; patient oriented research; preventive intervention; programs; protective factors; research study; residence; secondary analysis; sex; skills; social; social stigma; substance use; theories; training opportunity; transgender; transgender women; transmission process

PROJECT SUMMARY/ABSTRACT Transgender women have some of the highest rates of HIV in the world and are the highest HIV risk group in the United States and Brazil. Transgender women experience multiple stigmas that complicate their access to and adherence to healthcare, resulting in intersectional stigma and negative health outcomes. Intersectionality is a critical theory which posits that power relations construct our perspectives and experiences and has the potential to meaningfully inform research with transgender communities as well as an approach to mentorship across differences. Using novel applications of the framework of intersectionality, Dr. Jae Sevelius, Associate Professor in Residence, University of California, San Francisco, proposes (1) a plan for their own career development that will expand their research to include substance use and implementation science, (2) a plan to expand their program of research to provide ample training opportunities for mentees, and (3) a plan to provide mentoring focused on supporting mentees who are underrepresented in medicine (URM) and/or are launching a program of research focused on addressing health disparities among sexual and gender minorities (SGM). Their community-based, patient-oriented research is focused on the investigation of risk and protective factors in transgender communities and the relationship between stigma, discrimination, and health-related behaviors and outcomes. Dr. Sevelius' efforts have been dedicated to developing, implementing, and evaluating health promotion interventions that decrease health risks, including HIV transmission and acquisition, and improve treatment through behavioral changes, community programming, and increased access to culturally appropriate health care. Their research and scientific contribution of the trans-specific Model of Gender Affirmation is recognized nationally and internationally in the field of transgender health and HIV prevention and treatment. Mentee training will leverage the infrastructure and resources of Dr. Sevelius' ongoing intervention research and their collaborations with multidisciplinary and international researchers in the areas of HIV, substance use, and transgender health domestically and in Brazil. In order to expand the scope of their mentoring program, they propose to launch a group-based distance mentoring program, conduct facilitated writing intensives with their mentees, and produce scholarship and training in the area of intersectional mentoring. Lastly, Dr. Sevelius proposes to conduct K24 supported research studies that will serve as training vehicles for mentees and develop their research by (1) expanding their research experience and scholarship to include the characterization of substance use among transgender women within the context of HIV treatment, (2) cultivating expertise in implementation science to identify best practices for implementation of efficacious HIV prevention interventions among transgender populations who use substances, and (3) gaining experience assessing and contextualizing intersectional stigma among transgender populations in Brazil.

项目总结/摘要 跨性别妇女是世界上艾滋病毒感染率最高的群体，也是世界上艾滋病毒感染风险最高的群体。 美国和巴西。跨性别妇女经历了多种耻辱，使她们获得 和坚持医疗保健，导致交叉耻辱和负面的健康结果。交叉性 是一种批判理论，它认为权力关系构建了我们的观点和经验， 有可能为跨性别社区的研究提供有意义的信息，以及指导方法 跨越差异。利用交叉性框架的新应用，Jae Sevelius博士，助理 加州大学旧金山弗朗西斯科的驻校教授提出了（1）自己的职业规划 发展，这将扩大他们的研究，包括物质使用和实施科学，（2）一个计划 扩大研究计划，为学员提供充足的培训机会，以及（3）计划 提供辅导，重点支持在医学领域代表性不足和/或 启动一项研究计划，重点关注性和性别少数群体之间的健康差距 （SGM）。他们以社区为基础，以病人为导向的研究重点是调查风险和保护性 跨性别社区的因素以及耻辱、歧视和健康相关 行为和结果。Sevelius博士的努力一直致力于开发，实施， 评估健康促进干预措施，以减少健康风险，包括艾滋病毒传播， 获得，并通过行为改变，社区规划和增加 获得文化上适当的保健服务。他们的研究和科学贡献的反式特异性 性别肯定模式在跨性别健康领域获得国内和国际认可， 艾滋病毒预防和治疗。学员培训将利用Sevelius博士的基础设施和资源。 正在进行的干预研究及其与多学科和国际研究人员的合作， 艾滋病毒、药物使用和国内和巴西的变性人健康领域。为了扩大 他们的辅导计划的范围，他们建议推出一个基于小组的远程辅导计划，进行 促进写作密集与他们的学员，并产生奖学金和培训领域的 跨部门指导最后，Sevelius博士建议进行K24支持的研究， 作为学员的培训工具，并通过以下方式发展他们的研究：（1）扩大他们的研究经验 和奖学金，以包括变性妇女使用药物的特点， （2）培养实施科学方面的专门知识，以确定艾滋病毒治疗的最佳做法， 在使用艾滋病毒/艾滋病的变性人中实施有效的艾滋病毒预防干预措施 物质，和（3）获得经验，评估和情境交叉污名之间 巴西的跨性别人群。

项目成果

Correlates of Engagement in HIV Care Among Transgender Women of Color in the United States of America.

美国跨性别有色人种女性参与艾滋病毒护理的相关性。

• DOI: 10.1007/s10461-021-03306-9
• 发表时间: 2021
• 期刊: AIDS and behavior
• 影响因子: 4.4
• 作者: Sevelius,JaeM;Xavier,Jessica;Chakravarty,Deepalika;Keatley,JoAnne;Shade,Starley;Rebchook,Greg;SPNSTransgenderWomenofColorStudyGroup
• 通讯作者: SPNSTransgenderWomenofColorStudyGroup

Do Ask, Tell, and Show: Contextual Factors Affecting Sexual Orientation and Gender Identity Disclosure for Sexual and Gender Minority People.

• DOI: 10.1089/lgbt.2021.0159
• 发表时间: 2022-03
• 期刊: LGBT health
• 影响因子: 4.8
• 作者: Suen LW;Lunn MR;Sevelius JM;Flentje A;Capriotti MR;Lubensky ME;Hunt C;Weber S;Bahati M;Rescate A;Dastur Z;Obedin-Maliver J
• 通讯作者: Obedin-Maliver J

MDMA-assisted psychotherapy; Inclusion of transgender and gender diverse people in the frontiers of PTSD treatment trials.

• DOI: 10.3389/fpsyt.2022.932605
• 发表时间: 2022
• 期刊: FRONTIERS IN PSYCHIATRY
• 影响因子: 4.7
• 作者: Stauffer, Christopher S.;Brown, Melanie R.;Adams, Dee;Cassity, Marca;Sevelius, Jae
• 通讯作者: Sevelius, Jae

Mental Health and Gender Affirmation of Black and Latine Transgender/Nonbinary Youth Compared to White Peers Prior to Hormone Initiation.

• DOI: 10.1016/j.jadohealth.2023.06.022
• 发表时间: 2023-11
• 期刊: JOURNAL OF ADOLESCENT HEALTH
• 影响因子: 7.6
• 作者: Vance, Stanley R., Jr.;Chen, Diane;Garofalo, Robert;Glidden, David, V;Ehrensaft, Diane;Hidalgo, Marco;Tishelman, Amy;Rosenthal, Stephen M.;Chan, Yee-Ming;Olson-Kennedy, Johanna;Sevelius, Jae
• 通讯作者: Sevelius, Jae

Discordance in chromosomal and self-reported sex in the UK Biobank: Implications for transgender- and intersex-inclusive data collection.

• DOI: 10.1073/pnas.2218700120
• 发表时间: 2023-05-02
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Ackley, Sarah F.;Zimmerman, Scott C.;Flatt, Jason D.;Riley, Alicia R.;Sevelius, Jae;Duchowny, Kate A.
• 通讯作者: Duchowny, Kate A.