PRC Project--Butters

PRC项目--巴特斯

• 批准号: 8377366
• 负责人: MERYL A BUTTERS
• 金额: $ 18.91万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8377366
• 关键词: Adherence; Adult; Anxiety; Biological Markers; Blood Vessels; Butter; Caregivers; Child; Chronic; Cognitive; Communities; Community Networks; Comorbidity; Competence; Dementia; Doctor of Medicine; Doctor of Philosophy; Effectiveness; Elderly; Enrollment; Friends; Genotype; Hormones; Impaired cognition; Incidence; Individual; Inflammatory; Intervention; Life; Link; Major Depressive Disorder; Manuals; Measures; Mediating; Medical; Mental Depression; Modeling; Nerve Degeneration; Outcome; Pathologic; Prevention; Problem Solving; Procedures; Psychosocial Factor; Randomized; Risk; Role; Siblings; Social support; Spouses; Staging; Standardization; Stress; Toxic effect; Training; cognitive function; cytokine; geriatric depression; improved; instrumental activity of daily living; member; mild neurocognitive impairment; neuroinflammation; prevent; proband; problem solving therapy; stressor; therapy development; treatment as usual

Mild cognitive impairment (MCI) is a transitional state between normal cognitive function and dementia. Depression frequently co-occurs with MCI and each increases the risk of developing the other.(192-196) Cognitive loss may act as a stressor (much like any chronic and potentially progressive medical illness), associated with a constellation of psychosocial factors that have been linked to increased depression risk.(197199) Once older adults develop major depression, multiple pathologic mechanisms (i.e., vascular, neurodegenerative, stress hormone toxicity(200-201) likely mediated by neuroinflammation, increase the risk of cognitive decline (in the case of depression risk of progression to dementia is doubled).(202)

轻度认知功能障碍（MCI）是介于正常认知功能和痴呆之间的一种过渡状态。抑郁症经常与MCI同时发生，每一种都会增加发展另一种的风险。（192-196）认知丧失可能是一种应激源（就像任何慢性和潜在的进行性医学疾病一样），与一系列与抑郁风险增加有关的心理社会因素有关。（197199）一旦老年人发展为重度抑郁症，多种病理机制（即，血管、神经变性、应激激素毒性（200-201）可能由神经炎症介导，增加认知能力下降的风险（在抑郁症的情况下，进展为痴呆的风险增加一倍）。（202）