Reduce Risk of Diabetes:Healthy Lifestyle for Chinese Immigrants

描述（由申请人提供）：本R34申请的目的是根据糖尿病预防项目干预原则，创建并形成性评价一种干预措施，以促进有糖尿病风险的中国移民的健康生活方式。干预的可接受性和可行性将在一项双臂初步随机试验（n=60）中进行评估，该试验将比较生活方式干预（n=30）与最小控制干预（n=30）的效果。6个月结束时和12个月时的R34评估将检查体重和生物标志物的变化，包括空腹血糖和胰岛素、HbA 1c、血脂（总、HDL和LDL胆固醇以及甘油三酯）和血压。生活方式改变的措施将包括饮食摄入量和体育活动。该研究还将评估心理测量的变化。试点研究将使用RE-AIM评估框架，重点关注：覆盖范围-有多少符合条件的参与者实际入组研究？疗效/有效性-干预如何影响参与者的体重和其他指标？采纳：参与者对干预措施的接受程度如何？执行-有多少干预活动按计划提供？维持-干预效果有多少是可持续的？干预的长期效果将在随后的R18临床试验中进行评估。 公共卫生相关性：改变生活方式可以降低患糖尿病的风险。该项目将针对来自中国的高风险移民的需求，定制成功的糖尿病预防计划生活方式干预。干预的效果将在一项评估生活方式和体重变化的试点研究中进行评估。对干预措施的评估将用于计划一项更大的研究，以检查健康结果。

DESCRIPTION (provided by applicant): The goal of this R34 application is to create and formative evaluate an intervention that promotes healthful lifestyle for Chinese immigrants at risk for developing diabetes based on the principles of Diabetes Prevention Program intervention. The acceptability and feasibility of the intervention will be assessed in a two-arm pilot randomized trial (n=60) that will compare the effects of a lifestyle intervention (n=30) to a minimal control intervention (n=30). The R34 evaluation at the end of 6 months and at 12 months will examine changes in weight and biomarkers including fasting blood glucose and insulin, HbA1c, lipid profile (total, HDL and LDL cholesterol, and triglycerides), and blood pressure. Measures of lifestyle changes will include dietary intake and physical activity. The study will also assess change in psychological measures. The pilot study will use the RE-AIM evaluation framework to focus on: Reach - How many of the eligible participants actually enrolled in the study? Efficacy/Effectiveness -How did the intervention affect participant's weight and other measures? Adoption: How acceptable were the interventions to the participants? Implementation - How many of the intervention activities were provided as planned? Maintenance - How much of the intervention effect is sustainable? The longer term effects of the intervention will be evaluated in a subsequent R18 clinical trial. PUBLIC HEALTH RELEVANCE: Lifestyle change can reduce the risk of developing diabetes. This project will tailor the successful Diabetes Prevention Program lifestyle intervention to focus on the needs of high risk immigrants from China. The effects of the intervention will be evaluated in a pilot study assessing lifestyle and weight changes. The evaluation of the intervention will be used to plan a larger study to examine health outcomes.