Virology/Immunology Core

病毒学/免疫学核心

• 批准号: 8377549
• 负责人: Constantine G HAIDARIS
• 金额: $ 13.31万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8377549
• 关键词: Acquired Immunodeficiency Syndrome; Behavioral; Biological Assay; Clinical; Collaborations; Communicable Diseases; Core Facility; Cryopreservation; Development; Flow Cytometry; Goals; HIV; Human; Immunology; Immunology procedure; Improve Access; International; Laboratories; Mission; Recombinant Proteins; Recombinants; Research; Research Infrastructure; Research Personnel; South Africa; Specimen; Universities; base; design; instrumentation; interdisciplinary collaboration; repository; virology

The overall mission of the Virology/Immunology Core is to enhance HIV-related research and promote collaborations among HIV investigators, by providing improved access to virologic and immunologic assays, clinical specimens, and recombinant DMA constructs. The specific aims of this Core are: 1. To provide a centralized repository for clinical specimens and HIV-related recombinant DMA constructs that can be used by clinical, behavioral, and laboratory investigators. 2. To centralize, and improve access to, state-of-the-art virologic assays for clinical, behavioral, and laboratory investigators. 3. To provide a centralized facility that produces recombinant proteins relevant to HIV research. 4. To provide expertise in the design and interpretation of flow cytometry assays, and to improve access to the shared instrumentation necessary to conduct these studies. 5. To provide improved access to existing URMC core facilities. This core will utilize and augment already existing infrastructures, such as those in the Cold Storage Facility (Aim 1), Infectious Diseases Unit laboratories (Aim 2), Human Immunology Center (Aim 4), and existing core facilities (Aim 5) at the URMC. In addition, we will centralize expression of certain recombinant proteins (Aim 3), in order to provide economy of scale to investigators that use them in HIVrelated research. The Virology/Immunology Core will implement the overall mission of the UR D-CFAR by supporting a broad base of investigators from the UR and its international collaborators in South Africa, and promoting interdisciplinary collaborations among them.

病毒学/免疫学核心的总体任务是加强与艾滋病毒有关的研究和 促进艾滋病毒研究人员之间的合作，提供更好的病毒学和 免疫学分析、临床标本和重组DMA构建。 这一核心的具体目标是： 1.为临床标本和HIV相关的重组DNA提供一个集中的储存库 可供临床、行为和实验室研究人员使用的构造。 2.将最先进的病毒学分析用于临床、行为、 和实验室调查人员。 3.提供生产与艾滋病毒研究相关的重组蛋白的中央设施。 4.在设计和解释流式细胞仪分析方面提供专业知识，并改进 使用进行这些研究所需的共享仪器。 5.改善通往现有市建局核心设施的通道。 该核心将利用和增强现有的基础设施，例如冷藏中的基础设施 设施(目标1)、传染病股实验室(目标2)、人类免疫学中心(目标4)和 市建局现有的核心设施(目标5)。此外，我们还将集中表达某些 重组蛋白(目标3)，以便为在艾滋病毒相关研究中使用它们的研究人员提供规模经济 研究。病毒学/免疫学核心将执行UR D-CFAR的总体任务 通过支持UR及其在南方的国际合作者的广泛调查基础 非洲，并促进它们之间的跨学科合作。