Effects of temperature on mosquito immunity and vector competence: do some like i
温度对蚊子免疫力和媒介能力的影响:像我一样做一些
基本信息
- 批准号:8267001
- 负责人:
- 金额:$ 14.74万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-06-01 至 2014-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAreaBasic ScienceBloodBody TemperatureCladoceraCompetenceComplexCulicidaeDaphniaDevelopmentElementsEnvironmentEnvironmental Risk FactorExhibitsGenesHost resistanceHumanImmuneImmune responseImmunityImmunologyIndividualInsectaInvertebratesInvestigationKnowledgeLaboratoriesMalariaMediatingMetabolic PathwayModelingMolecularNational Institute of Allergy and Infectious DiseaseNatural ImmunityNatural ResistanceNatureNitric Oxide SynthaseParasite resistanceParasitesPerformancePhagocytosisPhenotypePhysiologyPlasmodiumPlasmodium falciparumPopulationPredispositionPublic HealthReactive Oxygen SpeciesRecoveryResearchResistanceRodentRunningShapesSupport SystemSystemTemperatureTestingTransgenic OrganismsTranslatingVariantVirulenceWorkantimicrobial peptideexperienceimmune functionimprovedinsightinterestpathogenresistance mechanismtooltransmission processvectorvector mosquitowarm temperature
项目摘要
DESCRIPTION (provided by applicant): There is considerable interest in understanding the mechanisms and function of mosquito innate immunity, with recent research in this area identifying important immune genes and metabolic pathways that appear to influence the ability of mosquitoes to transmit malaria. However nearly all such studies have been conducted under highly controlled lab environments, which is not what mosquitoes and Plasmodium parasites experience in the field. Natural malaria transmission occurs across a temperature range of 15-35 0 C, with the potential for considerable variation in conditions across temporal and spatial scales. We wish to test the hypothesis that temperature has significant impacts on mosquito immune function and vector competence, and to explore whether the insights gained under one set of controlled conditions are sufficient to understand variation in mosquito resistance/refractoriness in nature. We argue that mosquito immune function should be affected by environmental temperature because mosquitoes are small-bodied and cold-blooded. In other insect-parasite systems temperature has profound effects on parasite development and overall host resistance. Whether such effects occur with mosquitoes and malaria and if so, whether these effects are due to impacts of temperature on the parasite, on host immunity, or some combination of both, remains unclear. If temperature does affect mosquito immune function, then temperature may be a potent environmental parameter describing variation in mosquito resistance / refractoriness in natural vector populations and might also explain the disparities in immune responses to different Plasmodium parasites (in particular between some rodent malaria parasites and P. falciparum). More fundamentally, if mosquito immune response exhibits thermal sensitivity, the current approach of outlining immunological mechanism under standard lab conditions is insufficient for understanding natural or transgenic vector competence.
描述(由申请人提供):人们对了解蚊子先天免疫的机制和功能非常感兴趣,最近在该领域的研究确定了似乎影响蚊子传播疟疾能力的重要免疫基因和代谢途径。然而,几乎所有这些研究都是在高度受控的实验室环境下进行的,这与蚊子和疟原虫在野外的经历不同。疟疾的自然传播发生在15-35 ℃的温度范围内,在时间和空间尺度上,条件可能会有相当大的变化。我们希望测试的假设,温度对蚊子的免疫功能和载体的能力有显着的影响,并探讨是否在一组受控条件下获得的见解是足够的了解在自然界中的蚊子抗性/耐火性的变化。我们认为,蚊子的免疫功能应该受到环境温度的影响,因为蚊子是小型和冷血的。在其他昆虫-寄生虫系统中,温度对寄生虫发育和宿主整体抗性具有深远的影响。这种影响是否发生在蚊子和疟疾身上,如果是这样,这些影响是否是由于温度对寄生虫的影响,对宿主免疫力的影响,或者两者的某种组合,仍然不清楚。如果温度确实影响蚊子的免疫功能,那么温度可能是描述自然媒介种群中蚊子抗性/难治性变化的有效环境参数,也可能解释对不同疟原虫寄生虫(特别是某些啮齿类疟原虫和恶性疟原虫之间)的免疫反应差异。更根本的是,如果蚊子的免疫反应表现出热敏感性,目前的方法概述免疫机制在标准实验室条件下是不足以理解天然或转基因载体的能力。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Ambient temperature and dietary supplementation interact to shape mosquito vector competence for malaria.
- DOI:10.1016/j.jinsphys.2014.05.020
- 发表时间:2014-08
- 期刊:
- 影响因子:2.2
- 作者:Murdock, Courtney C.;Blanford, Simon;Luckhart, Shirley;Thomas, Matthew B.
- 通讯作者:Thomas, Matthew B.
Capacity of mosquitoes to transmit malaria depends on larval environment.
- DOI:10.1186/s13071-014-0593-4
- 发表时间:2014-12-14
- 期刊:
- 影响因子:3.2
- 作者:Moller-Jacobs LL;Murdock CC;Thomas MB
- 通讯作者:Thomas MB
Complex effects of temperature on mosquito immune function.
- DOI:10.1098/rspb.2012.0638
- 发表时间:2012-08-22
- 期刊:
- 影响因子:0
- 作者:Murdock CC;Paaijmans KP;Bell AS;King JG;Hillyer JF;Read AF;Thomas MB
- 通讯作者:Thomas MB
Complex environmental drivers of immunity and resistance in malaria mosquitoes.
- DOI:10.1098/rspb.2013.2030
- 发表时间:2013-11-07
- 期刊:
- 影响因子:0
- 作者:Murdock CC;Moller-Jacobs LL;Thomas MB
- 通讯作者:Thomas MB
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Matthew B Thomas其他文献
Temperature and transmission: novel estimates of the effects of temperature on the human malaria parasite, Plasmodium falciparum
温度与传播:温度对人类疟原虫恶性疟原虫影响的新估计
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Eunho Suh;I. Stopard;B. Lambert;J. L. Waite;Nina L Dennington;T. Churcher;Matthew B Thomas - 通讯作者:
Matthew B Thomas
Matthew B Thomas的其他文献
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{{ truncateString('Matthew B Thomas', 18)}}的其他基金
Quantifying insecticide impact on malaria transmission: does resistance matter?
量化杀虫剂对疟疾传播的影响:耐药性重要吗?
- 批准号:
8893244 - 财政年份:2015
- 资助金额:
$ 14.74万 - 项目类别:
Influence of temperature on malaria transmission and prospective vector control
温度对疟疾传播的影响和前瞻性病媒控制
- 批准号:
9042928 - 财政年份:2015
- 资助金额:
$ 14.74万 - 项目类别:
Quantifying insecticide impact on malaria transmission: does resistance matter?
量化杀虫剂对疟疾传播的影响:耐药性重要吗?
- 批准号:
9101941 - 财政年份:2015
- 资助金额:
$ 14.74万 - 项目类别:
Effects of temperature on mosquito immunity and vector competence: do some like i
温度对蚊子免疫力和媒介能力的影响:像我一样做一些
- 批准号:
8176272 - 财政年份:2011
- 资助金额:
$ 14.74万 - 项目类别:
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