ContraPest-an oral bait for fertility management of rodent pests

ContraPest-一种用于啮齿类害虫生育管理的口服诱饵

• 批准号: 8338856
• 负责人: Rachel Patrice Allred
• 金额: $ 46.28万
• 依托单位: SENESTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8338856
• 关键词: Address; Agriculture; Animals; Anticoagulants; Area; Arizona; Back; Camping; Chemicals; Communicable Diseases; Consumption; Cost of Illness; Data; Development; Disease; Disease Outbreaks; Disease Vectors; Distress; Drug Formulations; Eating; Economics; Environment; Environmental Pollution; Exclusion; Female; Fertility; Food; Goals; Human; Incidence; Laboratories; Laboratory Rat; Litter Size; Magic; Methods; Modeling; Navajo; New York City; Norway; Oral; Pain; Phase; Pilot Projects; Poison; Poisoning; Population; Practice Management; Premature Ovarian Failure; Primordial Follicle; Principal Investigator; Process; Production; Rattus; Rattus norvegicus; Reporting; Research Infrastructure; Rodent; Rodenticides; Safety; Series; Site; Southeastern Asia; Sterility; Subway; System; Technology; Time; Training; United States; commercialization; efficacy testing; experience; field study; improved; novel strategies; programs; pup; research study; suburb; tool

DESCRIPTION (provided by applicant): In this phase II application, we propose to test the efficacy of our platform technology derived product, ContraPest(R), a chemosterilant rat bait containing 4-vinylcyclohexene diepoxide (VCD), in reduction of the brown rat population in a model urban setting, the subway stations of New York City (NYC). Our phase II application is comprised of 3 aims. Aim 1 is focused on establishing the safety parameters of our technology, including exclusion of non-target species and impact on the environment. Aim 2 is focused on establishing the feasibility of performing pilot studies in NYC using wild caught brown rat populations both from Arizona and from NYC. Aim 3 is focused on performing a series of pilot studies in NYC to test the efficacy of ContraPest(R) bait in reducing the brown rat population in defined areas of the subway stations in NYC. In phase I we successfully demonstrated the efficacy of orally administered VCD in reducing primordial follicle number and litter size in R. norvegicus laboratory rats (the same species as the brown rat of NYC). We also determined that our current agricultural bait formulation (a pellet bait) is highly palatable to laboratory ras and consumption of our bait results in reduction in fertility in females. Current rat control practices in NYC are focused on rodenticide use. Poison packs are thrown off the back of subway trains onto the tracks. This is largely ineffective primarily due to the abundance of more palatable food choices (i.e. trash) and because poison application frequently results in population rebound effects. While there is no "magic bullet" to reducing rat pest populations, we believe that our technology can be used as an adjunct to current rodent pest management practices to have a sustainable significant impact on the reduction of the urban brown rat population. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

描述（由申请人提供）：在这个II期申请中，我们建议测试我们的平台技术衍生产品contr抑鼠剂(R)的功效，这是一种含有4-乙烯基环己烯二氧化物（VCD）的化学灭菌鼠饵，在一个模型城市环境中，即纽约市（NYC）的地铁站中减少褐鼠的数量。我们的第二阶段应用程序由3个目标组成。目标1的重点是建立我们技术的安全参数，包括排除非目标物种和对环境的影响。目标2的重点是确定在纽约市进行试点研究的可行性，使用来自亚利桑那州和纽约市的野生棕鼠种群。目标3的重点是在纽约市进行一系列试点研究，以测试contrapu (R)诱饵在纽约市地铁站指定区域减少褐鼠种群的功效。在I期实验中，我们成功地证明了口服VCD对褐家鼠实验大鼠（与纽约市褐鼠相同的物种）减少原始卵泡数量和产仔数的功效。我们还确定，我们目前的农业饵料配方（颗粒饵料）对实验室ras来说非常可口，食用我们的饵料会导致雌性生育力下降。纽约市目前的老鼠控制措施主要集中在杀鼠剂的使用上。毒包被从地铁车厢扔到铁轨上。这在很大程度上是无效的，主要是因为有大量更美味的食物选择（如垃圾），而且由于毒药的使用经常导致种群反弹效应。虽然没有减少鼠害的“灵丹妙药”，但我们相信，我们的技术可以作为当前鼠害管理措施的辅助措施，对减少城市褐鼠种群产生可持续的重大影响。小灵通398/2590 （Rev. 06/09）页延续格式页