ContraPest-an oral bait for fertility management of rodent pests

ContraPest-一种用于啮齿类害虫生育管理的口服诱饵

• 批准号: 8256560
• 负责人: Rachel Patrice Allred
• 金额: $ 38.16万
• 依托单位: SENESTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8256560
• 关键词: Address; Agriculture; Animals; Anticoagulants; Area; Arizona; Back; Camping; Chemicals; Communicable Diseases; Consumption; Cost of Illness; Data; Development; Disease; Disease Outbreaks; Disease Vectors; Distress; Drug Formulations; Eating; Economics; Environment; Environmental Pollution; Exclusion; Female; Fertility; Food; Goals; Human; Incidence; Laboratories; Laboratory Rat; Litter Size; Magic; Methods; Modeling; Navajo; New York City; Norway; Oral; Pain; Phase; Pilot Projects; Poison; Poisoning; Population; Practice Management; Premature Ovarian Failure; Primordial Follicle; Principal Investigator; Process; Production; Rattus; Rattus norvegicus; Reporting; Research Infrastructure; Rodent; Rodenticides; Safety; Series; Site; Southeastern Asia; Sterility; Subway; System; Technology; Time; Training; United States; commercialization; efficacy testing; experience; field study; improved; novel strategies; programs; pup; research study; suburb; tool

DESCRIPTION (provided by applicant): In this phase II application, we propose to test the efficacy of our platform technology derived product, ContraPest(R), a chemosterilant rat bait containing 4-vinylcyclohexene diepoxide (VCD), in reduction of the brown rat population in a model urban setting, the subway stations of New York City (NYC). Our phase II application is comprised of 3 aims. Aim 1 is focused on establishing the safety parameters of our technology, including exclusion of non-target species and impact on the environment. Aim 2 is focused on establishing the feasibility of performing pilot studies in NYC using wild caught brown rat populations both from Arizona and from NYC. Aim 3 is focused on performing a series of pilot studies in NYC to test the efficacy of ContraPest(R) bait in reducing the brown rat population in defined areas of the subway stations in NYC. In phase I we successfully demonstrated the efficacy of orally administered VCD in reducing primordial follicle number and litter size in R. norvegicus laboratory rats (the same species as the brown rat of NYC). We also determined that our current agricultural bait formulation (a pellet bait) is highly palatable to laboratory ras and consumption of our bait results in reduction in fertility in females. Current rat control practices in NYC are focused on rodenticide use. Poison packs are thrown off the back of subway trains onto the tracks. This is largely ineffective primarily due to the abundance of more palatable food choices (i.e. trash) and because poison application frequently results in population rebound effects. While there is no "magic bullet" to reducing rat pest populations, we believe that our technology can be used as an adjunct to current rodent pest management practices to have a sustainable significant impact on the reduction of the urban brown rat population. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page PUBLIC HEALTH RELEVANCE: Management of urban rats is critical to decrease the incidences of human-rat interactions and thus lower the spread of rodent borne infectious diseases and reduce infrastructure damage. Current control methods such as rodenticides introduce poisons into the environment and are largely ineffective. The goal of this project is two-fold: identify safety issues associated with a chemosterilant bait containing the ovotoxicant chemical, 4- vinylcyclohexene diepoxide (VCD), and to establish baiting requirements necessary to induce subterranean urban rat population reduction in a model setting (the NYC subway). PHS 398/2590 (Rev. 11/07) Page Continuation Format Page

描述（由申请人提供）：在本II期申请中，我们建议测试我们的平台技术衍生产品ContraPest（R）（一种含有4-乙烯基环己烯双环氧化物（VCD）的化学绝育鼠饵）在减少棕色老鼠数量方面的功效。在模型城市环境中，即纽约市（NYC）的地铁站。我们的第二阶段应用程序由3个目标组成。目标1的重点是建立我们技术的安全参数，包括排除非目标物种和对环境的影响。目标2的重点是确定在纽约市进行试点研究的可行性，使用野生捕获的棕色大鼠种群从亚利桑那州和纽约市。目标3的重点是在纽约市进行一系列试点研究，以测试ContraPest（R）诱饵在减少纽约市地铁站特定区域内褐鼠数量方面的功效。在第一阶段，我们成功地证明了口服VCD在减少R原始卵泡数量和窝仔数方面的疗效。norvegicus实验室大鼠（与NYC的棕色大鼠同种）。我们还确定，我们目前的农业诱饵制剂（颗粒诱饵）对实验室RAS是高度适口的，并且我们的诱饵的消耗导致雌性生育力降低。纽约市目前的灭鼠措施主要集中在灭鼠剂的使用上。有毒的包裹从地铁列车的后部扔到铁轨上。这在很大程度上是无效的，主要是由于丰富的更可口的食物选择（即垃圾），因为毒药的应用往往导致人口反弹的影响。虽然没有减少鼠害种群的“灵丹妙药”，但我们相信，我们的技术可以作为当前啮齿动物害虫管理实践的辅助手段，对减少城市褐鼠种群产生可持续的重大影响。PHS 398/2590（Rev.06/09） 公共卫生相关性：管理城市老鼠对于减少人鼠相互作用的发生率，从而降低啮齿动物传染病的传播和减少基础设施的破坏至关重要。目前的控制方法，如灭鼠剂，将毒物引入环境中，并且在很大程度上无效。该项目的目标是双重的：确定与含有卵毒性化学物质4-乙烯基环己烯二环氧化物（VCD）的化学绝育诱饵相关的安全问题，并建立诱导模型设置（纽约地铁）中地下城市大鼠种群减少所需的诱饵要求。PHS 398/2590（Rev. 11/07）