Investigating Molecular-Genetic Correlates of Fatigue

研究疲劳的分子遗传学相关性

• 批准号: 8554730
• 负责人: Leorey Saligan
• 金额: $ 16.74万
• 依托单位: NATIONAL INSTITUTE OF NURSING RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8554730
• 关键词: Aerobic Exercise; Affective; Behavioral; Biological Markers; Cancer Patient; Cognitive; Collection; Data; Dimensions; Disease; Emotional; Energy Metabolism; Exercise; External Beam Radiation Therapy; Fatigue; Gene Expression; Goals; Hour; IL8 gene; Impaired cognition; Incidence; Individual; Inflammatory; Insulin-Like Growth Factor I; Interleukin-6; Intervention; Leukocytes; Life Experience; Long-Term Effects; Longitudinal Studies; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Mental Depression; Molecular Genetics; Observational Study; Oxidative Stress; Patient Self-Report; Patients; Physical activity; Physiological; Population; Prostatectomy; Psyche structure; Radiation therapy; Risk; Sensory; Severities; Sex Functioning; Skeletal Muscle; Symptoms; TNF gene; Time; Training; cytokine; experience; gastrointestinal; gastrointestinal symptom; health related quality of life; muscle strength; patient population; programs; prospective; prostate surgery; theories; urinary

Although the underlying mechanisms of fatigue have been studied in several disease conditions, the data are not conclusive, and this symptom remains poorly managed at present. Longitudinal studies related to treatment-related fatigue in prostate cancer patients have been conducted, but there are limited studies exploring the changes in physiologic mechanisms before and after radiotherapy which can identify individuals who are at risk for enduring fatigue during and after therapy. Fatigue is conceptualized as a multidimensional symptom which incorporates temporal, sensory, cognitive/mental, affective/emotional, behavioral, and physiological dimensions. This prospective, observational study is the first study to explore the molecular-genetic mechanisms underlying fatigue and the cluster of symptoms (urinary, sexual, gastrointestinal, psychiatric) experienced by prostate cancer patients undergoing External Beam Radiation Therapy (EBRT). The primary objective of the study is to describe the changes in the self-reported fatigue; urinary, sexual, and gastrointestinal symptoms; depression; fatigue catastrophizing; and health-related quality of life (HRQOL) experienced by patients with and without prostate surgery before, during, and after EBRT completion. The secondary objectives of this study are to investigate the pro-inflammatory cytokine profile of EBRT-related fatigue (TNF, IGF-I, IL-6, IL-8, TGF and ) and to determine changes in white blood cell gene expression using buffy coat collection before, during, and after EBRT completion and to relate these changes in the levels of these biological markers to self-reported fatigue; urinary, sexual, and gastrointestinal symptoms; depression; fatigue catastrophizing; and HRQOL scores. This study also aims to measure the skeletal muscle strength, activity levels and energy expenditure of patients before, during, and at completion of EBRT and relate these findings with self-reported fatigue, physical symptoms (e.g. urinary, gastrointestinal, and sexual functioning), depression, and HRQOL scores.

虽然疲劳的潜在机制已经在几种疾病条件下进行了研究，但数据并不确定，目前这种症状仍然管理不善。已经进行了与前列腺癌患者治疗相关疲劳相关的纵向研究，但探索放射治疗前后生理机制变化的研究有限，这些研究可以识别治疗期间和治疗后存在持久疲劳风险的个体。疲劳被概念化为多维症状，其包括时间、感觉、认知/精神、情感/情绪、行为和生理维度。这项前瞻性、观察性研究是第一项探索前列腺癌患者接受外照射放射治疗（EBRT）时出现疲劳和一系列症状（泌尿、性、胃肠道、精神）的分子遗传机制的研究。 本研究的主要目的是描述在EBRT完成之前、期间和之后，接受和未接受前列腺手术的患者自我报告的疲劳、泌尿系统、性和胃肠道症状、抑郁、疲劳灾难化和健康相关生活质量（HRQOL）的变化。本研究的次要目的是研究EBRT相关疲劳的促炎细胞因子谱（TNF、IGF-I、IL-6、IL-8、TGF和），并在EBRT完成之前、期间和之后使用血沉棕黄层收集来确定白色血细胞基因表达的变化，并将这些生物标志物水平的这些变化与自我报告的疲劳相关联;泌尿、性和胃肠道症状;抑郁;疲劳灾难化;和HRQOL评分。 本研究还旨在测量EBRT之前、期间和完成时患者的骨骼肌强度、活动水平和能量消耗，并将这些结果与自我报告的疲劳、身体症状（例如泌尿系统、胃肠道和性功能）、抑郁和HRQOL评分相关。