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Regulation of T cell responses during chronic infection by Toxoplasma gondii

弓形虫慢性感染期间 T 细胞反应的调节

基本信息

批准号：
8291200
负责人：
ELLEN A ROBEY
金额：
$ 19.19万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8291200
关键词：
Acquired Immunodeficiency Syndrome Address Adult Alleles Antigen Presentation Antigen-Presenting Cells Antigens Behavior Brain CD8B1 gene Cell Communication Cell physiology Cells Chronic Congenital Abnormality Cyst Cytoplasmic Granules Data Development Disease Event Experimental Models Frequencies Goals Granuloma Human Image Immune Immune response Immune system In Situ Infection Infection Control Invaded Life Light Location Malaria Mammals Mediating Methods Microscopy Modeling Monitor Mouse Strains Mus Nature Neurologic Outcome Ovalbumin Parasites Pathology Patients Peptides Phenotype Photons Proteins Regulation Regulatory T-Lymphocyte Reporter Role Signal Transduction Site Specificity T cell response T-Lymphocyte Testing Tissues Toxoplasma Toxoplasma gondii Toxoplasmosis cell type foodborne infection imaging modality immunoregulation in vivo insight macrophage mouse model novel strategies pathogen prevent response therapeutic development

项目摘要

DESCRIPTION (provided by applicant): Toxoplasma gondii is an intracellular protozoan parasite that is the causative agent of Toxoplasmosis. Toxoplasma infection in mice provides an excellent experimental model for understanding food borne infections and chronic infections of the brain. The overall goal of this project is to gain a deeper understanding of how the mammalian immune system responds to chronic Toxoplasma infection by tracking parasites and immune cells in the brain. Specifically, we propose to examine how T cell interactions with parasites and invaded host cells changes during progressing versus controlled chronic infection (Aim 1), to investigate the key features that distinguish a protective CD8 T cell response from a non-protective one (Aim 2), and to investigate the role of regulatory T cells in modulating T cell effectors responses (Aim 3).

描述（由申请方提供）：弓形虫是一种细胞内原生动物寄生虫，是弓形虫病的病原体。小鼠弓形虫感染为了解食源性感染和脑慢性感染提供了极好的实验模型。该项目的总体目标是通过跟踪大脑中的寄生虫和免疫细胞，更深入地了解哺乳动物免疫系统如何对慢性弓形虫感染作出反应。具体而言，我们建议检查T细胞与寄生虫和入侵的宿主细胞的相互作用如何在进展与控制慢性感染（目标1），研究区分保护性CD8 T细胞反应与非保护性T细胞反应的关键特征（目标2），并研究调节性T细胞在调节T细胞效应子反应中的作用（目标3）。