Molecular Virology Core
分子病毒学核心
基本信息
- 批准号:8440952
- 负责人:
- 金额:$ 18.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:Acquired Immunodeficiency SyndromeBiohazardous SubstanceBiological AssayCell LineCellsCertificationClinicalCollaborationsCommitContainmentCore FacilityDNADetectionDiagnosticEmerging Communicable DiseasesEnsureExpenditureFosteringFundingGrantGuidelinesHIV-1Human ResourcesLocationMissionMolecularMolecular BiologyMolecular VirologyMonitorPathogenesisPrimate LentivirusesRNAReagentResearchResearch PersonnelResearch TechnicsResourcesSafetyServicesSiteSourceStudentsT-LymphocyteTimeTitrationsTrainingTropismUnited States National Institutes of HealthViralViral GenomeVirusWorkWorkplacebasecost effectivemacrophageoperationoutreachrepositoryweb site
项目摘要
The overall objectives of UMass CFAR Molecular Virology Core facility are: (1) to maintain and continuously monitor the safety operations of a BSL3- and a BSL2-containment facility that will support a safe and biohazard-free environment for work with pathogenic primate immunodeficiency viruses; (2) to provide resources and services to participating CFAR investigators for their ongoing virus-related projects; and (3) to function as a central site where collaborations amongst UMass CFAR investigators is fostered. The Core services include: (1) assays for isolation, titration, phenotypic and genotypic characterization of virus; (2) providing a centralized source and repository for primary T-cells, macrophages & T-cell lines; and (3) molecular detection/diagnostic assays including qualitative and quantitative RNA and DNA-PCR for viral genomes & state of the art, cutting edge LightCycler-based PCR assays for real-time detection and quantitation of HIV-1. The Molecular Virology Core facility, in conjunction with UMass CFAR-Clinical and Molecular Biology Core facilities, uphold the mission of UMass CFAR by providing standardized and centralized routine research techniques and reagents; reducing expenditure by eliminating duplication of
effort & by efficient use of personnel; and fostering new collaborative projects and grants. The Molecular Virology Core is also committed to provide educational & training opportunities to CFAR investigators and students/fellows in working within BSL3 containment facility, in developing new molecular virology assays, in BSL3 Certification, and in PCR Certification. Details of the Molecular Virology Core facility, its location, its
functions, the services provided are all available on the UMass CFAR Molecular Virology Core website (www.umassmed.edu/cfar/viroloavcore).
麻省理工大学CFAR分子病毒学核心设施的总体目标是:(1)维持和持续监测BSL3和bsl2遏制设施的安全运行,这将为致病性灵长类免疫缺陷病毒的工作提供安全和无生物危害的环境;(2)为参与的CFAR调查人员正在进行的病毒相关项目提供资源和服务;(3)作为促进马萨诸塞大学CFAR研究人员之间合作的中心站点。核心服务包括:(1)病毒的分离、滴定、表型和基因型鉴定;(2)为原代t细胞、巨噬细胞和t细胞系提供集中的来源和存储库;(3)分子检测/诊断分析,包括用于病毒基因组的定性和定量RNA和DNA-PCR和最新技术,用于实时检测和定量HIV-1的基于lightcycler的尖端PCR分析。分子病毒学核心设施与麻省理工学院临床和分子生物学核心设施一起,通过提供标准化和集中的常规研究技术和试剂,维护麻省理工学院临床和分子生物学核心设施的使命;通过消除重复来减少开支
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MOHAN SOMASUNDARAN其他文献
MOHAN SOMASUNDARAN的其他文献
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{{ truncateString('MOHAN SOMASUNDARAN', 18)}}的其他基金
MOLECULAR DETERMINANTS OF CELL DEATH BY HIV1
HIV1 导致的细胞死亡的分子决定因素
- 批准号:
2876549 - 财政年份:1998
- 资助金额:
$ 18.21万 - 项目类别: