Cancer GENETICS AND EPIGENETICS

癌症遗传学和表观遗传学

• 批准号: 8512116
• 负责人: Paula M. Vertino
• 金额: $ 3.02万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8512116
• 关键词: Affect; Area; Automobile Driving; Basic Science; Bioinformatics; Biometry; Brain; Breast; Cancer Center Support Grant; Cells; Chromatin; Chromosomal Instability; Classification; Clinical; Collaborations; DNA; DNA Damage; DNA Repair; DNA Sequence; Defect; Detection; Development; Diagnosis; Direct Costs; Disease Outcome; Doctor of Philosophy; Epigenetic Process; Failure; Functional RNA; Funding; Gene Expression Regulation; Genes; Genetic; Genome; Genomic Instability; Genomics; Genomics Shared Resource; Goals; Grant; Human; Individual; Institutes; Instruction; Investigation; Journals; Lung; Malignant Neoplasms; Methylation; MicroRNAs; Molecular; Molecular Classification of Tumors; Mutation; Normal Cell; Nucleotides; Outcome; Oxidative Stress; Pathway interactions; Patients; Pattern; Peer Review; Phenotype; Positioning Attribute; Prevention; Program Development; Prostate; Public Health Schools; Publications; Publishing; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Schools; Screening procedure; Source; System; Therapeutic; Therapeutic Intervention; Translating; Translations; Universities; Variant; anticancer research; cancer care; cancer cell; cancer genetics; cancer genome; cancer genomics; cancer initiation; cancer therapy; college; environmental radiation; gene function; genetic analysis; genome-wide; histone modification; improved; medical schools; member; mortality; novel; novel strategies; outcome forecast; prognostic; programs; radiation carcinogen; radiation carcinogenesis; repaired; response; small molecule; translational study; tumor; tumor progression; tumorigenesis

PROJECT SUMMARY: The goal of the Cancer Genetics and Epigenetics (CGE) Program is to better understand the fundamental mechanisms underlying genetic and epigenetic instability and its contribution to the initiation and progression of human tumors. In pursuit of this goal, the program organizes its research efforts into three areas of focus: 1) DNA damage and repair and genome instability; 2) epigenetics and gene regulation; and 3) cancer genetics /genomics. The CGE Program consists of 29 core members from 13 academic departments and three schools across Emory University, including the School of Medicine, the School of Public Health and Emory College. CGE Program members currently have $15,110,592 in research grant funding (annual direct costs), of which $12,849,105 is peer-reviewed and $4,277,290 (34%) is NCI-funded. Program members have published 227 cancer-related publications in the cun-ent project period. Among these, 12% and 25% represent intra- and inter-programmafic and interactions, respectively. In the current project period, discovery efforts have led to the identification of key genes whose mutation or altered expression contribute to cancer initiation and progression. Basic discoveries in the area of cancer epigenetics have prompted early small molecule screening efforts to identify novel targeted agents. Program development and key recruitments have strengthened and enhanced intra-programmatic activities in the areas of human radiation carcinogenesis, DNA damage/repair, and cancer genomics. This has been leveraged into several new multi-investigator grants and has provided key translational avenues for the program through increased inter-programmatic activities and cross-cutting genomics initiatives. Successful genomic studies resulted in the molecular classification of tumors and the identification of genes, gene signatures, and clinical factors with prognostic value in prostate, breast, brain, and lung malignancies. The Cancer Genetics and Epigenetics Program facilitates scientific collaborations and cancer research discoveries and has positioned itself for continued development in the forthcoming project period.

项目概要： 癌症遗传学和表观遗传学（CGE）计划的目标是更好地了解遗传和表观遗传不稳定性的基本机制及其对人类肿瘤发生和发展的贡献。为了实现这一目标，该计划将其研究工作分为三个重点领域：1）DNA损伤和修复以及基因组不稳定性; 2）表观遗传学和基因调控; 3）癌症遗传学/基因组学。 CGE计划由来自埃默里大学13个学术部门和三所学校的29名核心成员组成，包括医学院，公共卫生学院和埃默里学院。CGE计划成员目前拥有15，110，592美元的研究资助资金（年度直接成本），其中12，849，105美元是同行评审，4，277，290美元（34%）是NCI资助的。在目前的项目期间，项目成员已经出版了227份与癌症相关的出版物。其中，12%和25%分别代表方案内和方案间的相互作用。 在当前的项目期间，发现工作已经导致了关键基因的鉴定，这些基因的突变或改变的表达有助于癌症的发生和发展。癌症表观遗传学领域的基本发现促使早期的小分子筛选努力，以确定新的靶向药物。 方案的制定和关键的招聘加强和提高了在人类辐射致癌作用，DNA损伤/修复和癌症基因组学领域的方案内活动。这已被利用到几个新的多研究者赠款，并通过增加跨计划活动和跨领域基因组学举措为该计划提供了关键的转化途径。成功的基因组研究导致了肿瘤的分子分类和基因的鉴定， 特征，以及在前列腺、乳腺、脑和肺恶性肿瘤中具有预后价值的临床因素。癌症遗传学和表观遗传学项目促进了科学合作和癌症研究发现，并为即将到来的项目期间的持续发展做好了准备。