UNC Oncology Clinical Translational Research Training Program

描述(由申请人提供)：在这份申请中，北卡罗来纳大学教堂山分校(UNC)成人和儿童血液/肿瘤科、放射肿瘤学系、北卡罗来纳大学莱恩伯格综合癌症中心(LCCC)和胃肠病和肝病学部提议更新对北卡罗来纳大学肿瘤学临床/转化性研究培训计划(OCT-RTP)的资助。所有四个组成部分都将为拟议的培训计划提供导师和研究资源，除北卡罗来纳大学-LCCC之外的所有组成部分都将贡献学者。OCT-RTP每年将招收两名学者。诺曼·夏普莱斯博士是医学和遗传学教授，血液学/肿瘤学分部成员，LCCC转译研究副主任。夏普莱斯博士在小鼠模型、新疗法、I期试验和知识产权商业化领域的癌症研究方面拥有丰富的经验。托马斯·斯廷奇科姆博士，副教授兼血液学/肿瘤学奖学金项目主任，新担任项目主任。该计划的目标是建立一支积极性高、训练有素的内科临床研究人员队伍，他们在寻求研究支持方面具有竞争力，并将成为成功的、独立的、以患者为导向的癌症研究人员。将为OCT-RTP提供的培训资源包括：莱恩伯格综合癌症中心、北卡罗来纳州癌症医院、北卡罗来纳大学医学院K30临床研究课程和北卡罗来纳大学关于种族文化和健康结果的计划。OCT-RTP的目标是提高以患者为中心的研究的质量和数量，包括临床研究的所有阶段，特别是涉及翻译部分的阶段。拟议培训计划的基础将是分配给每位学者的高素质基础科学和临床导师的参与，导师活动由导师整合小组协调。一个由四个组成部分的资深教师组成的内部咨询委员会将挑选和监督学者的进展，而外部咨询委员会将每年审查该项目。自成立以来，OCT-RTP已招收了6名学者，他们的记录详细载于进度报告。随着一些教职员工的离开和新教职员工的招聘，我们的导师小组发生了变化。一名外部顾问委员会成员已经轮换，由威廉·布莱克斯托克医学博士接替。自最初的资助以来，该计划的设施和资源已得到发展，以确保对该计划的更强有力的支持。 公共卫生相关性：癌症研究中实验室和临床发现的快速发展促使人们需要培养能够同时进行临床和实验室研究的新一代癌症研究人员，这通常被称为转化性研究。这支充满进取心、训练有素的新医生队伍的发展将加快癌症护理的进展速度。北卡罗来纳大学K12项目的目的是通过一项包括必修课、研究支持、补助金撰写支持和资深教员密切指导的计划来帮助这些医生的发展。在K12项目中，来自放射肿瘤学、成人和儿科肿瘤学、胃肠病学和肝病学领域的学者将与莱恩伯格综合癌症中心的高级研究人员就一个研究项目进行合作。该计划的最终目标是培养将独立资助的临床科学家和研究项目，以及能够指导下一代医生的医生。

DESCRIPTION (provided by applicant): In this application, the University of North Carolina at Chapel Hill (UNC) Divisions of Adult and Pediatric Hematology/Oncology, the Department of Radiation Oncology, the UNC Lineberger Comprehensive Cancer Center (LCCC) and the Division of Gastroenterology and Hepatology propose to renew funding for the UNC Oncology Clinical/ Translational Research Training Program (OCT-RTP). All four of the components will contribute mentors and research resources to the proposed training program, and all components except UNC-LCCC will contribute scholars. OCT-RTP will admit two scholars per year. The PI, Dr. Norman Sharpless, is Professor of Medicine and Genetics, a member of the Hematology/Oncology division, and is the LCCC Associate Director for Translational Research. Dr. Sharpless has extensive experience in cancer research in the areas of murine models, novel therapeutics, Phase I trials and commercialization of intellectual property. Dr Thomas Stinchcombe, Associate Professor and Hematology/Oncology fellowship program director, has newly assumed the role of Program Director. The program's objectives are to establish a highly motivated and rigorously trained cadre of physician clinical researchers who are competitive in seeking research support and who will become successful, independent patient-oriented cancer investigators. Training resources that will be available for the OCT-RTP include: the Lineberger Comprehensive Cancer Center, the North Carolina Cancer Hospital, the UNC School of Medicine K30 Clinical Research Curriculum and the UNC Program on Ethnicity Culture and Health Outcomes. The goals of the OCT-RTP are to increase the quality and quantity of patient-oriented research, including all phases of clinical research and particularly that involving a translational component. The foundation of the proposed training program will be the participation of highly qualified basic science and clinical mentors assigned to each scholar with mentoring activities coordinated by a mentor integration panel. An internal advisory committee that includes senior faculty from each of the four components will select and monitor the progress of scholars, while an external advisory committee will review the program annually. Since its inception, the OCT-RTP has enrolled six Scholars who records are detailed in the progress report. Our mentorship panel has evolved as some faculty members have left and new faculty have been recruited. One external advisory board member has rotated off and been replaced by A William Blackstock MD. Facilities and resources for the program have evolved to insure even stronger support for this program since its initial funding. PUBLIC HEALTH RELEVANCE: The rapid pace of both laboratory and clinical discoveries in cancer research has created the need to develop a new generation of cancer researchers who are able to perform both clinical and laboratory research, often referred to as translational research. The development of this new cadre of highly motivated and rigorously trained physicians will accelerate the speed of advances in cancer care. The purpose of the K12 program at UNC is to assist in the development of these physicians through a program of required courses, research support, grant writing support, and close mentoring by senior faculty members. While in the K12 program scholars from the fields of radiation oncology, adult and pediatric oncology, gastroenterology and hepatology will collaborate with senior investigators at Lineberger Comprehensive Cancer Center on a research project. The ultimate goal of the program is to develop clinician scientists and research projects that will be independently funded, and physicians who will be able to mentor the next generation of physicians.