UNC Oncology Clinical Translational Research Training Program

描述（由申请人提供）：在这份申请中，北卡罗来纳大学教堂山分校（UNC）成人和儿童血液学/肿瘤学部门，放射肿瘤学部门，北卡罗来纳大学莱恩伯格综合癌症中心（LCCC）和胃肠病学和肝脏病学部门提议为北卡罗来纳大学肿瘤学临床/转化研究培训计划（OCT-RTP）更新资金。所有四个组成部分都将为拟议的培训计划提供导师和研究资源，除了UNC-LCCC之外的所有组成部分都将提供学者。OCT-RTP每年将招收两名学者。首席研究员Norman Sharpless博士是医学和遗传学教授，是血液学/肿瘤学部门的成员，也是LCCC转化研究副主任。Sharpless博士在小鼠模型、新疗法、I期试验和知识产权商业化领域的癌症研究方面拥有丰富的经验。Thomas Stinchcombe博士，副教授兼血液学/肿瘤学奖学金项目主任，新近担任项目主任一职。该计划的目标是建立一支积极主动、训练有素的临床医师研究骨干队伍，他们在寻求研究支持方面具有竞争力，并将成为成功的、独立的、以患者为导向的癌症研究人员。OCT-RTP将提供的培训资源包括：Lineberger综合癌症中心、北卡罗来纳癌症医院、北卡罗来纳大学医学院K30临床研究课程和北卡罗来纳大学种族文化和健康成果项目。OCT-RTP的目标是提高以患者为导向的研究的质量和数量，包括临床研究的所有阶段，特别是涉及转化成分的研究。拟议的培训计划的基础将是为每位学者分配高素质的基础科学和临床导师，并由导师整合小组协调指导活动。一个内部咨询委员会，包括来自四个组成部分的高级教师，将选择和监督学者的进展，而一个外部咨询委员会将每年审查该项目。自成立以来，OCT-RTP已经招收了六位学者，他们的详细记录在进度报告中。随着一些教员的离开和新教员的招募，我们的导师小组也在不断发展。一名外部顾问委员会成员已经轮休，由威廉·布莱克斯托克医学博士取代。项目的设施和资源已经发展，以确保项目自初始资金以来得到更强有力的支持。

DESCRIPTION (provided by applicant): In this application, the University of North Carolina at Chapel Hill (UNC) Divisions of Adult and Pediatric Hematology/Oncology, the Department of Radiation Oncology, the UNC Lineberger Comprehensive Cancer Center (LCCC) and the Division of Gastroenterology and Hepatology propose to renew funding for the UNC Oncology Clinical/ Translational Research Training Program (OCT-RTP). All four of the components will contribute mentors and research resources to the proposed training program, and all components except UNC-LCCC will contribute scholars. OCT-RTP will admit two scholars per year. The PI, Dr. Norman Sharpless, is Professor of Medicine and Genetics, a member of the Hematology/Oncology division, and is the LCCC Associate Director for Translational Research. Dr. Sharpless has extensive experience in cancer research in the areas of murine models, novel therapeutics, Phase I trials and commercialization of intellectual property. Dr Thomas Stinchcombe, Associate Professor and Hematology/Oncology fellowship program director, has newly assumed the role of Program Director. The program's objectives are to establish a highly motivated and rigorously trained cadre of physician clinical researchers who are competitive in seeking research support and who will become successful, independent patient-oriented cancer investigators. Training resources that will be available for the OCT-RTP include: the Lineberger Comprehensive Cancer Center, the North Carolina Cancer Hospital, the UNC School of Medicine K30 Clinical Research Curriculum and the UNC Program on Ethnicity Culture and Health Outcomes. The goals of the OCT-RTP are to increase the quality and quantity of patient-oriented research, including all phases of clinical research and particularly that involving a translational component. The foundation of the proposed training program will be the participation of highly qualified basic science and clinical mentors assigned to each scholar with mentoring activities coordinated by a mentor integration panel. An internal advisory committee that includes senior faculty from each of the four components will select and monitor the progress of scholars, while an external advisory committee will review the program annually. Since its inception, the OCT-RTP has enrolled six Scholars who records are detailed in the progress report. Our mentorship panel has evolved as some faculty members have left and new faculty have been recruited. One external advisory board member has rotated off and been replaced by A William Blackstock MD. Facilities and resources for the program have evolved to insure even stronger support for this program since its initial funding. PUBLIC HEALTH RELEVANCE: The rapid pace of both laboratory and clinical discoveries in cancer research has created the need to develop a new generation of cancer researchers who are able to perform both clinical and laboratory research, often referred to as translational research. The development of this new cadre of highly motivated and rigorously trained physicians will accelerate the speed of advances in cancer care. The purpose of the K12 program at UNC is to assist in the development of these physicians through a program of required courses, research support, grant writing support, and close mentoring by senior faculty members. While in the K12 program scholars from the fields of radiation oncology, adult and pediatric oncology, gastroenterology and hepatology will collaborate with senior investigators at Lineberger Comprehensive Cancer Center on a research project. The ultimate goal of the program is to develop clinician scientists and research projects that will be independently funded, and physicians who will be able to mentor the next generation of physicians.