UNC Oncology Clinical Translational Research Training Program

北卡罗来纳大学肿瘤学临床转化研究培训计划

• 批准号: 8921117
• 负责人: NORMAN E SHARPLESS
• 金额: $ 13.51万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-17 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8921117
• 关键词: Adult; Advisory Committees; Area; Basic Science; Cancer Hospital; Clinical; Clinical Oncology; Clinical Research; Comprehensive Cancer Center; Educational Curriculum; Enrollment; Ethnic Origin; Faculty; Fellowship Program; Foundations; Funding; Gastroenterology; Genetic Medicine; Goals; Health; Hematology; Hepatology; Intellectual Property; Left; Malignant Neoplasms; Mentors; Mentorship; Modeling; Monitor; Mus; North Carolina; Outcome; Pediatric Hematology; Phase; Physicians; Program Reviews; Progress Reports; Qualifying; Radiation Oncology; Records; Recruitment Activity; Research Personnel; Research Support; Research Training; Resources; Role; Training; Training Programs; Translational Research; UNC Lineberger Comprehensive Cancer Center; Universities; anticancer research; commercialization; experience; medical schools; member; novel therapeutics; oncology; patient oriented; patient oriented research; phase I trial; professor; programs

DESCRIPTION (provided by applicant): In this application, the University of North Carolina at Chapel Hill (UNC) Divisions of Adult and Pediatric Hematology/Oncology, the Department of Radiation Oncology, the UNC Lineberger Comprehensive Cancer Center (LCCC) and the Division of Gastroenterology and Hepatology propose to renew funding for the UNC Oncology Clinical/ Translational Research Training Program (OCT-RTP). All four of the components will contribute mentors and research resources to the proposed training program, and all components except UNC-LCCC will contribute scholars. OCT-RTP will admit two scholars per year. The PI, Dr. Norman Sharpless, is Professor of Medicine and Genetics, a member of the Hematology/Oncology division, and is the LCCC Associate Director for Translational Research. Dr. Sharpless has extensive experience in cancer research in the areas of murine models, novel therapeutics, Phase I trials and commercialization of intellectual property. Dr Thomas Stinchcombe, Associate Professor and Hematology/Oncology fellowship program director, has newly assumed the role of Program Director. The program's objectives are to establish a highly motivated and rigorously trained cadre of physician clinical researchers who are competitive in seeking research support and who will become successful, independent patient-oriented cancer investigators. Training resources that will be available for the OCT-RTP include: the Lineberger Comprehensive Cancer Center, the North Carolina Cancer Hospital, the UNC School of Medicine K30 Clinical Research Curriculum and the UNC Program on Ethnicity Culture and Health Outcomes. The goals of the OCT-RTP are to increase the quality and quantity of patient-oriented research, including all phases of clinical research and particularly that involving a translational component. The foundation of the proposed training program will be the participation of highly qualified basic science and clinical mentors assigned to each scholar with mentoring activities coordinated by a mentor integration panel. An internal advisory committee that includes senior faculty from each of the four components will select and monitor the progress of scholars, while an external advisory committee will review the program annually. Since its inception, the OCT-RTP has enrolled six Scholars who records are detailed in the progress report. Our mentorship panel has evolved as some faculty members have left and new faculty have been recruited. One external advisory board member has rotated off and been replaced by A William Blackstock MD. Facilities and resources for the program have evolved to insure even stronger support for this program since its initial funding.

描述（由申请人提供）：在本申请中，北卡罗来纳州查佩尔山大学（北卡罗来纳州）成人和儿童血液学/肿瘤学分部、放射肿瘤学系、Lineberger综合癌症中心（LCCC）和胃肠病学和肝病学分部提议更新对肿瘤学临床/转化研究培训计划（OCT-RTP）的资助。所有四个组成部分都将为拟议的培训方案提供导师和研究资源，除UNC-LCCC外，所有组成部分都将提供学者。OCT-RTP每年招收两名学者。PI Norman Sharpless博士是医学和遗传学教授，血液学/肿瘤学部门的成员，也是LCCC转化研究副主任。 Sharpless博士在小鼠模型、新型疗法、I期试验和知识产权商业化等领域的癌症研究方面拥有丰富的经验。托马斯Stinchcombe博士，副教授和血液学/肿瘤学奖学金项目主任，新承担了项目主任的角色。该计划的目标是建立一个高度积极性和严格训练的医生临床研究人员谁是在寻求研究支持的竞争力，谁将成为成功的，独立的以病人为导向的癌症研究人员的干部。OCT-RTP将提供的培训资源包括：Lineberger综合癌症中心、北卡罗来纳州癌症医院、麻省理工学院K30临床研究课程和种族文化与健康成果项目。OCT-RTP的目标是提高以患者为导向的研究的质量和数量，包括临床研究的所有阶段，特别是涉及翻译部分的研究。拟议的培训计划的基础将是高素质的基础科学和临床导师的参与，分配给每个学者与导师整合小组协调的指导活动。一个内部咨询委员会，其中包括来自四个组成部分的每一个高级教师将选择和监测学者的进展，而外部咨询委员会将审查该计划每年。自成立以来，OCT-RTP已经招收了六名学者，他们的记录详见进度报告。我们的导师小组已经演变为一些教师已经离开和新的教师已被招募。一名外部顾问委员会成员已轮换离职，由A William Blackstock MD取代。该方案的设施和资源已经发展，以确保自最初供资以来对该方案的更有力支持。