Training in Molecular & Genetic Epidemiology of Cancer

描述（由申请人提供）：该提案是R25 T癌症教育和职业发展计划的竞争性更新，用于癌症遗传和分子流行病学（GMEC）的博士后培训。当前的癌症研究时代为理解致癌的遗传和环境原因提供了非凡的工具。最大限度地使用这些工具需要来自不同背景的科学家团队的投入，包括分子生物学，肿瘤学，医学，遗传学，流行病学和生物统计学。在这些领域受过跨学科教育的个人对这些团队的成功至关重要。特别是，它们可以作为完成一些最有前途的研究所需的综合工作的渠道。然而，大多数培训机会的重点性质使调查人员获得连接这些学科的知识的机会有限。为了解决这个问题，我们建议继续目前的GMEC培训计划。 该计划的总体具体目标是为杰出的博士后候选人提供一系列教学和研究机会，以促进他们作为癌症遗传和分子流行病学跨学科“领域”的独立研究人员的职业生涯。导师和研究培训机会将继续来自旧金山弗朗西斯科湾区的主要学术和研究机构，包括加州大学旧金山弗朗西斯科和伯克利分校、凯萨医疗机构、斯坦福大学和北方加州癌症中心。该计划非常适合R25 T资助机制，因为它培养了多个不同领域交叉的科学家。更具体地说，GMEC计划以高度互动的方式将来自癌症研究，分子生物学，遗传学，流行病学和生物统计学的一组导师和学员融合在一起。该计划由三个主要组成部分定义：1）涵盖关键学科及其交叉点的专业核心课程; 2）额外的教育经验，以补充他们的研究和教育背景和兴趣;和3）有多个导师的重点研究项目。每个学员还将被要求通过撰写模拟NIH提案来扩展他们的研究经验。在该计划中接受培训的个人将拥有破译癌症原因的关键技能，最终提供有关预防和治疗这种复杂疾病的宝贵知识。

DESCRIPTION (provided by applicant): This proposal is a competitive renewal of a R25T Cancer Education and Career Development Program for postdoctoral training in Genetic and Molecular Epidemiology of Cancer (GMEC). The current era of cancer research is providing extraordinary tools for understanding the genetic and environmental causes of carcinogenesis. Using these tools to their fullest extent requires input from teams of scientists with a mixture of backgrounds, including molecular biology, oncology, medicine, genetics, epidemiology, and biostatistics. Individuals with trans-disciplinary education across these fields are crucial to the success of such teams. In particular, they can serve as the conduit for the integrated work necessary to accomplish some of the most promising research. However, the focused nature of most training opportunities provides limited opportunities for investigators to obtain the knowledge that bridges these disciplines. To address this issue, we propose continuing the current GMEC training program. The overall specific aim of this program is to offer a set of instructional and research opportunities to exceptional postdoctoral candidates in order to promote their careers as independent researchers in the interdisciplinary "field" of genetic and molecular epidemiology of cancer. Mentors and research training opportunities will continue to come from major academic and research institutions in the San Francisco Bay Area, including the University of California San Francisco and Berkeley, Kaiser Permanente, Stanford University, and the Northern California Cancer Center. This program is uniquely suited to the R25T grant mechanism because it trains scientists at the intersection of multiple distinct fields. More specifically, the GMEC program blends together in a highly interactive fashion a group of mentors and trainees from cancer research, molecular biology, genetics, epidemiology, and biostatistics. The program is defined by three main components: 1) a specialized core curriculum that covers the key disciplines and their intersections; 2) additional educational experiences to complement their research and educational background and interest; and 3) focused research projects with multiple mentors. Each trainee will also be required to extend their research experience by writing a mock NIH proposal. Individuals trained in this program will have the skills vital to deciphering the causes of cancer, ultimately providing valuable knowledge regarding the prevention and treatment of this complex disease.