CORE B - LIGAND ASSAY AND ANALYSIS CORE

作为国家RSB资源，配体测定和分析核心将在U 54中发挥重要作用 中心和其他RSB支持的中心。首先，核心将提供高质量，成本效益的分析 服务其次，开发新的最先进的检测方法，以满足研究者的需求。第三、 核心将提供有关分析方法、数据简化/分析 数据解释和生物数学建模。 生殖激素的准确、精确和可靠的测量是至关重要的 配体核心使命的一部分设立核心融资机制的理由涉及到 节省费用，资源和人员，以内部和外部资源管理局支持的调查员，因为他们将 不需要在每个实验室开发和维护这些方法。的技术专长和 由每个研究者进行大量或不同测试所需的设备将是低效的， 把精力和资源从重要的研究问题上转移开。此外，中央核心设施可以实现 分析性能、质量控制和数据简化的统一标准。实施新 方法或改进现有方法需要技术专门知识，这将是昂贵和低效的 由每个项目调查员在内部建立。建立核心的主要理由之一是， 以具有成本效益的方式提供最先进的化验服务。这一使命将包括开发 灵敏度和特异性增强的检测，将方法从放射性转移到非放射性 自动化设备的实施（用于大容量测试）。分析自动化可以增强 通过提高测定精度来提高测定性能，并通过增加 可以由技术人员进行。最后，为其他RSB支持的中心和其他 弗吉尼亚大学的生殖科学家，促进合作精神，可能导致未来的 调查人员之间的合作。

As a National RSB Resource, the Ligand Assay and Analysis Core will serve an essential role in this U54 Center, and other RSB-supported Centers. First, the Core will provide high quality, cost effective assay services. Second, develop new state-of-the-art assay methods to accommodate investigator needs. Third, the Core will provide assistance and consultation regarding assay methodology, data reduction/analysis, data interpretation and biomathematical modeling. The accurate, precise and dependable measurement of reproductive hormones is an essential component in the mission of Ligand Core. The justification for establishing a Core facility relates to the savings in cost, resources and personnel to internal and external RSB-supported investigators, as they will not need to develop and maintain these methods in each individual laboratory. The technical expertise and equipment required to perform high volume or diverse testing by each investigator would be inefficient and divert effort and resources from important research questions. Also, a central Core facility can implement uniform standards for assay performance, quality controls and data reduction. The implementation of new methods or enhancement of current methods require technical expertise that would be costly and inefficient to establish in-house by each project investigator. One of the major rationales for establishing the Core is to provide state of the art assay services in a cost efficient manner. This mission will include development of assays with enhanced sensitivity and specificity, transferring methods from radioactive to nonradioactive systems, implementation of automation equipment (for high volume tests). Assay automation can enhance assay performance by improving assay precision and reducing costs by increasing the number of tests that can be performed by the technologist. Finally, providing services to other RSB-supported Centers and other reproductive scientists within the University of Virginia, promote a spirit of cooperation that may lead to future collaborations between investigators.