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Engineering Analysis of Minimally Invasive Mitral Valve Repair

微创二尖瓣修复工程分析

基本信息

批准号：
8311672
负责人：
Thuy M Pham
金额：
$ 3.2万
依托单位：
UNIVERSITY OF CONNECTICUT STORRS
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-23 至 2013-12-22
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8311672
关键词：
ABCB6 gene Achievement Anatomy Biological Biomechanics Biomedical Technology Cadaver Cardiac Cardiac Surgery procedures Cardiology Cardiovascular system Clinical Computer Simulation Computer software Connecticut Coronary sinus structure Data Data Analyses Databases Device Designs Devices Disease Doctor of Medicine Doctor of Philosophy Economic Inflation Education Elasticity Elements Engineering Evaluation Fellowship Fiber Generations Great cardiac vein structure Health Heart Heart Valve Diseases Heart Valves Histology Human Human Subject Research Image Implant Industry Intervention Knowledge Learning Measurement Mechanics Methods Microanatomy Mitral Valve Modeling Myocardium Participant Patients Physiology Process Property Research Research Ethics Research Training Residual state Rhode Island Science Series Simulate Solid Structure Surface Techniques Testing The Sun Tissue Model Tissues Training Universities Validation Work computer studies computerized tools design high risk innovation insight member minimally invasive novel pressure professor prototype repaired research study simulation soft tissue success theories tool viscoelasticity

项目摘要

DESCRIPTION (provided by applicant): The purpose of this research training fellowship is to provide the candidate with a unique opportunity to learn the interdisciplinary knowledge of heart valve disease and its treatment using engineering tools. The candidate will learn how to apply engineering mechanics principles, computational technologies and biomedical sciences to solve clinical issues related to heart valve disease treatment. To accomplish this training plan, the candidate will conduct research to investigate the biomechanics involved in minimally invasive mitral valve repair, through a combined experimental and computational study, to better understand underlying valve repair mechanisms, and to facilitate novel intervention device design. Specifically, the following specific aims will be achieved: 1) Quantify the elastic properties of coronary sinus (CS)/great cardiac vein (GCV), and mitral valve tissues as well as adjacent myocardium. 2) Utilize constitutive models to accurately model tissue properties. 3) Generate 3D Finite Element (FE) models of the mitral valve apparatus from excised human hearts and cardiac CT images, and validate the FE models. Methods: The candidate will perform a series of experiments to characterize mitral tissue properties. Histology analysis will be conducted to study the microstructures of tissues and to understand tissue structure-function relations. A rigorous strain energy function will be applied to accurately model the tissue properties, which will in turn be incorporated into FE simulations. 3D geometries of associated tissues will be recreated from physical measurements of excised hearts and cardiac images. Model error estimation will be performed and simulation results will be validated through comparison with experiment data. The achievements will be 1) the establishment of databases of biomechanical properties, geometries and FE models for analyzing minimally invasive mitral valve repair treatment; 2) the candidate will gain extensive training and an in-depth understanding of the cardiovascular biomechanics, especially the mechanics related to heart valve disease. PUBLIC HEALTH RELEVANCE: This research is relevant to a minimally invasive treatment of mitral valve disease, in particular for high-risk patients who cannot undergo open-heart surgery. Findings of this study will offer insights for better device designs and valve disease treatments.

描述（由申请人提供）：本研究培训奖学金的目的是为候选人提供一个独特的机会，学习心脏瓣膜疾病及其使用工程工具治疗的跨学科知识。候选人将学习如何应用工程力学原理，计算技术和生物医学科学来解决与心脏瓣膜疾病治疗相关的临床问题。为了完成这一培训计划，候选人将通过实验和计算相结合的研究来研究微创二尖瓣修复所涉及的生物力学，以更好地了解潜在的二尖瓣修复机制，并促进新型介入装置的设计。具体而言，将实现以下具体目标：1)量化冠状窦(CS)/心大静脉（GCV）、二尖瓣组织及邻近心肌的弹性特性。2)利用本构模型准确模拟组织特性。3)根据切除的人体心脏和心脏CT图像生成二尖瓣装置的三维有限元模型，并对有限元模型进行验证。方法：候选人将进行一系列实验来表征二尖瓣组织特性。组织学分析将用于研究组织的微观结构，了解组织结构与功能的关系。一个严格的应变能函数将被应用于准确地模拟组织特性，这将被纳入有限元模拟。相关组织的三维几何形状将从切除的心脏和心脏图像的物理测量中重建。进行模型误差估计，并通过与实验数据的对比验证仿真结果。研究成果将包括：1)建立生物力学特性、几何形状和有限元模型数据库，用于分析微创二尖瓣修复治疗；2)候选人将获得广泛的培训，并深入了解心血管生物力学，特别是与心脏瓣膜疾病相关的力学。