High resolution ultrasound imaging sensor array for biomedical imaging applicatio

用于生物医学成像应用的高分辨率超声成像传感器阵列

• 批准号: 8550132
• 负责人: Sang-Woo Seo
• 金额: $ 12.55万
• 依托单位: CITY COLLEGE OF NEW YORK
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-24 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550132
• 关键词: Accounting; Acoustics; Arterial Fatty Streak; Arteries; Biological; Biomedical Engineering; Blood Vessels; Breast Microcalcification; Catheters; Cessation of life; Characteristics; Clinical; Collagen; Coronary Arteriosclerosis; Detection; Development; Diagnostic Procedure; Diagnostic Specificity; Disease; Event; Film; Goals; Heart; Hematoxylin and Eosin Staining Method; Human; Image; Imaging Device; Imaging Techniques; In Vitro; Laboratories; Light; Lipids; Magnetic Resonance Imaging; Mechanics; Methods; Microscope; Microscopic; Miniaturization; Morphology; Necrosis; Noise; Optics; Patients; Penetration; Polymers; Price; Research; Resolution; Risk; Roentgen Rays; Role; Rupture; Sampling; Scanning; Signal Transduction; Spectrum Analysis; Staging; Staining method; Stains; Structure; Sudden Death; System; Technology; Thick; Three-Dimensional Image; Time; Tissues; Transducers; Translating; Ultrasonic Transducer; Ultrasonic wave; Ultrasonography; United States National Institutes of Health; acute coronary syndrome; base; bioimaging; cardiovascular risk factor; coronary artery calcification; cost; design; imaging modality; in vivo; microchip; molecular imaging; novel; photonics; pressure; screening; sensor; tomography; tool

DESCRIPTION (provided by applicant): Rupture of the thin fibrous cap overlying the necrotic core of a vulnerable plaque is the principal cause of acute coronary syndrome. Fibrous cap rupture lies at the heart of reducing cardiovascular risk since it accounts for half of all coronar artery disease deaths and, moreover, occurs without warning in moderate-risk and asymptomatic patients. Of paramount importance to characterize and better understand the vulnerable plaque rupture mechanism is the insufficient resolution of clinically available imaging tools capable of provide high resolution morphology of the atheroma in real-time. Development of the proposed imaging sensor and its imaging method will permit identifying thin cap fibroatheromas (TCFA) and quantify coronary artery calcification with greater detail than with current imaging approaches, and will open the possibility of posing new fundamental questions related to the mechanism of TCFA rupture. Specific Aim 1 is to develop thin film acousto-optic transducer for conventional CMOS based camera systems. Based on the optical ultrasound detection method, the transducer will eliminate the requirement for many hundreds of active transducer channels, severe fabrication difficulties in electrical interconnection, and low transducer signal to noise ratio especially for the large imaging array size. Specific Aim 2 is to develop novel imaging acquisition method that allows the developed transducer with a conventional CMOS camera for high resolution ultrasound imaging. Finally, Specific Aim 3 is determine the ability of the developed acousto-optic ultrasound imaging system to identify microscopic tissue composition at high resolution in real-time. It will be used for both imaging of the morphology of the fibroatheroma and presence of microcalcifications as well as the tissue composition spectroscopy of fibrous cap, necrotic core and collagen content. The successful implementation of the proposed transducer and image acquisition method will allow an unprecedented high resolution ultrasound imaging that is impossible to achieve from conventional piezoelectric or capacitive micromachined ultrasound transducers.

描述（由申请人提供）：脆弱斑块坏死核心上的薄纤维帽破裂是急性冠状动脉综合征的主要原因。纤维帽破裂是降低心血管风险的核心，因为它占所有冠状动脉疾病死亡的一半，而且在中等风险和无症状患者中发生时没有警告。表征和更好地理解易损斑块破裂机制的最重要的是能够实时提供动脉粥样化的高分辨率形态的临床可用成像工具的分辨率不足。所提出的成像传感器及其成像方法的发展将允许识别薄帽纤维粥样硬化（TCFA）和量化冠状动脉钙化与更详细的比目前的成像方法，并将打开提出新的基本问题的可能性TCFA破裂的机制。具体目标1是开发用于传统CMOS相机系统的薄膜声光换能器。基于光学超声检测方法，换能器将消除对数百个有源换能器通道的需求，消除电气互连中的严重制造困难，以及特别是对于大成像阵列尺寸的低换能器信噪比。具体目标2是开发新的成像采集方法，允许开发的换能器与传统的CMOS相机进行高分辨率超声成像。最后，具体目标3是确定所开发的声光超声成像系统以高分辨率实时识别微观组织成分的能力。它将用于成像， 纤维粥样硬化的形态和微钙化的存在以及纤维帽、坏死核心和胶原含量的组织成分光谱。所提出的换能器和图像采集方法的成功实施将允许前所未有的高分辨率超声成像，这是不可能实现从传统的压电或电容式微机械超声换能器。