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Acquisition of a high resolution thermal camera for photothermal stimulator characterization.

获取高分辨率热相机用于光热刺激器表征。

基本信息

批准号：
10798518
负责人：
Sang-Woo Seo
金额：
$ 8.7万
依托单位：
CITY COLLEGE OF NEW YORK
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-05 至 2026-08-31
项目状态：
未结题

项目摘要

Project Summary/Abstract Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), affect more than 10 million Americans. Unfortunately, many patients eventually suffer vision loss due to no available therapeutic cure for these diseases. Retinal prosthesis is the only available option to make artificial interfaces to restore a damaged neural path. Electrical stimulation-based retinal prostheses have been most widely used due to their conceptual simplicity. However, it faces many hurdles due to complex signal interfaces, especially for high spatial resolution. A novel approach based on the principle of stimulating neuronal cells with a direct optical-induced thermal signal is introduced to potentially offer more advantages over the electrical stimulation approach. However, the concept is relatively new, and necessary engineered means should be developed to translate this approach to retinal prostheses. The goal of the proposed research is to create a two-dimensional array of photothermal pixels, of which the thermal stimulation is directly controlled by incoming light images. Based on the optical stimulation approach, this will address many challenges that the current electrical stimulation face, especially for large area stimulation. Successful completion of the proposed research will represent a revolutionary advance on the photothermal-based stimulation method and open a new opportunity of using photothermal stimulation in retinal prostheses.

项目概要/摘要视网膜退行性疾病，例如色素性视网膜炎 (RP) 和年龄相关性黄斑变性 (AMD)，影响超过 1000 万美国人。不幸的是，许多患者最终因以下原因而遭受视力丧失：这些疾病没有可用的治疗方法。视网膜假体是唯一可行的选择人工接口来恢复受损的神经路径。基于电刺激的视网膜假体已被由于其概念简单而被最广泛使用。然而，由于信号复杂，它面临着许多障碍接口，特别是对于高空间分辨率。一种基于刺激原理的新颖方法引入具有直接光诱导热信号的神经元细胞可能会提供更多优势 over the electrical stimulation approach.然而，这个概念相对较新，并且需要经过精心设计应开发手段将这种方法转化为视网膜假体。拟议的目标研究目的是创建一个二维光热像素阵列，其中的热刺激直接 controlled by incoming light images.基于光刺激方法，这将解决许多问题当前电刺激面临的挑战，特别是大面积刺激。成功的拟议研究的完成将代表光热基技术的革命性进步刺激方法并为在视网膜假体中使用光热刺激开辟了新的机会。