Acquisition of a high resolution thermal camera for photothermal stimulator characterization.

获取高分辨率热相机用于光热刺激器表征。

• 批准号: 10798518
• 负责人: Sang-Woo Seo
• 金额: $ 8.7万
• 依托单位: CITY COLLEGE OF NEW YORK
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-05 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10798518
• 关键词: Administrative Supplement; Affect; Age related macular degeneration; American; Area; Award; Blindness; Cells; Complex; Devices; Disease; Electric Stimulation; Electrodes; Engineering; Equipment; Face; Fluorescent Dyes; Funding; Goals; Hydrogels; Image; Light; Measurement; Methods; National Institute of General Medical Sciences; Neurons; Optics; Parents; Patients; Photoreceptors; Productivity; Research; Resolution; Retinal Degeneration; Retinitis Pigmentosa; Signal Transduction; System; Temperature; Therapeutic; Thermography; Time; Translating; United States National Institutes of Health; equipment acquisition; fabrication; improved; instrument; manufacturing systems; neural; neural stimulation; novel strategies; retinal prosthesis; spatiotemporal; temporal measurement; two-dimensional

Project Summary/Abstract Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), affect more than 10 million Americans. Unfortunately, many patients eventually suffer vision loss due to no available therapeutic cure for these diseases. Retinal prosthesis is the only available option to make artificial interfaces to restore a damaged neural path. Electrical stimulation-based retinal prostheses have been most widely used due to their conceptual simplicity. However, it faces many hurdles due to complex signal interfaces, especially for high spatial resolution. A novel approach based on the principle of stimulating neuronal cells with a direct optical-induced thermal signal is introduced to potentially offer more advantages over the electrical stimulation approach. However, the concept is relatively new, and necessary engineered means should be developed to translate this approach to retinal prostheses. The goal of the proposed research is to create a two-dimensional array of photothermal pixels, of which the thermal stimulation is directly controlled by incoming light images. Based on the optical stimulation approach, this will address many challenges that the current electrical stimulation face, especially for large area stimulation. Successful completion of the proposed research will represent a revolutionary advance on the photothermal-based stimulation method and open a new opportunity of using photothermal stimulation in retinal prostheses.

项目总结/文摘

项目成果

Hydrogel Micropillar Array for Temperature Sensing in Fluid.

• DOI: 10.1109/jsen.2023.3293433
• 发表时间: 2023-09
• 期刊: IEEE SENSORS JOURNAL
• 影响因子: 4.3
• 作者: Seo, Sang-Woo;Song, Youngsik;Mustakim, Nafis
• 通讯作者: Mustakim, Nafis