Acquisition of a high resolution thermal camera for photothermal stimulator characterization.
获取高分辨率热相机用于光热刺激器表征。
基本信息
- 批准号:10798518
- 负责人:
- 金额:$ 8.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-05 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:Administrative SupplementAffectAge related macular degenerationAmericanAreaAwardBlindnessCellsComplexDevicesDiseaseElectric StimulationElectrodesEngineeringEquipmentFaceFluorescent DyesFundingGoalsHydrogelsImageLightMeasurementMethodsNational Institute of General Medical SciencesNeuronsOpticsParentsPatientsPhotoreceptorsProductivityResearchResolutionRetinal DegenerationRetinitis PigmentosaSignal TransductionSystemTemperatureTherapeuticThermographyTimeTranslatingUnited States National Institutes of Healthequipment acquisitionfabricationimprovedinstrumentmanufacturing systemsneuralneural stimulationnovel strategiesretinal prosthesisspatiotemporaltemporal measurementtwo-dimensional
项目摘要
Project Summary/Abstract
Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration
(AMD), affect more than 10 million Americans. Unfortunately, many patients eventually suffer vision loss due to
no available therapeutic cure for these diseases. Retinal prosthesis is the only available option to make
artificial interfaces to restore a damaged neural path. Electrical stimulation-based retinal prostheses have been
most widely used due to their conceptual simplicity. However, it faces many hurdles due to complex signal
interfaces, especially for high spatial resolution. A novel approach based on the principle of stimulating
neuronal cells with a direct optical-induced thermal signal is introduced to potentially offer more advantages
over the electrical stimulation approach. However, the concept is relatively new, and necessary engineered
means should be developed to translate this approach to retinal prostheses. The goal of the proposed
research is to create a two-dimensional array of photothermal pixels, of which the thermal stimulation is directly
controlled by incoming light images. Based on the optical stimulation approach, this will address many
challenges that the current electrical stimulation face, especially for large area stimulation. Successful
completion of the proposed research will represent a revolutionary advance on the photothermal-based
stimulation method and open a new opportunity of using photothermal stimulation in retinal prostheses.
项目概要/摘要
视网膜退行性疾病,例如色素性视网膜炎 (RP) 和年龄相关性黄斑变性
(AMD),影响超过 1000 万美国人。不幸的是,许多患者最终因以下原因而遭受视力丧失:
这些疾病没有可用的治疗方法。视网膜假体是唯一可行的选择
人工接口来恢复受损的神经路径。基于电刺激的视网膜假体已被
由于其概念简单而被最广泛使用。然而,由于信号复杂,它面临着许多障碍
接口,特别是对于高空间分辨率。一种基于刺激原理的新颖方法
引入具有直接光诱导热信号的神经元细胞可能会提供更多优势
over the electrical stimulation approach.然而,这个概念相对较新,并且需要经过精心设计
应开发手段将这种方法转化为视网膜假体。拟议的目标
研究目的是创建一个二维光热像素阵列,其中的热刺激直接
controlled by incoming light images.基于光刺激方法,这将解决许多问题
当前电刺激面临的挑战,特别是大面积刺激。成功的
拟议研究的完成将代表光热基技术的革命性进步
刺激方法并为在视网膜假体中使用光热刺激开辟了新的机会。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hydrogel Micropillar Array for Temperature Sensing in Fluid.
- DOI:10.1109/jsen.2023.3293433
- 发表时间:2023-09
- 期刊:
- 影响因子:4.3
- 作者:Seo, Sang-Woo;Song, Youngsik;Mustakim, Nafis
- 通讯作者:Mustakim, Nafis
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Sang-Woo Seo其他文献
Sang-Woo Seo的其他文献
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{{ truncateString('Sang-Woo Seo', 18)}}的其他基金
Development of a photothermal stimulator array for controlled neuron stimulation
开发用于受控神经元刺激的光热刺激器阵列
- 批准号:
10411554 - 财政年份:2022
- 资助金额:
$ 8.7万 - 项目类别:
Light-actuated Chemical Stimulator for Retinal Prosthesis Interface
用于视网膜假体接口的光驱动化学刺激器
- 批准号:
9043098 - 财政年份:2015
- 资助金额:
$ 8.7万 - 项目类别:
Light-actuated Chemical Stimulator for Retinal Prosthesis Interface
用于视网膜假体接口的光驱动化学刺激器
- 批准号:
8892358 - 财政年份:2015
- 资助金额:
$ 8.7万 - 项目类别:
High resolution ultrasound imaging sensor array for biomedical imaging applicatio
用于生物医学成像应用的高分辨率超声成像传感器阵列
- 批准号:
8550132 - 财政年份:2012
- 资助金额:
$ 8.7万 - 项目类别:
High resolution ultrasound imaging sensor array for biomedical imaging applicatio
用于生物医学成像应用的高分辨率超声成像传感器阵列
- 批准号:
8338250 - 财政年份:2012
- 资助金额:
$ 8.7万 - 项目类别:
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