Cardiovascular Imaging in Ischemic Heart Disease

缺血性心脏病的心血管成像

• 批准号: 8495408
• 负责人: UDO HOFFMANN
• 金额: $ 12.79万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8495408
• 关键词: Acute; Address; Anatomy; Ancillary Study; Atherosclerosis; Biological Assay; Biological Markers; Blood; Cardiac; Cardiology; Cardiovascular Diseases; Charge; Chest Pain; Clinical; Clinical Investigator; Clinical Research; Computer Assisted; Coronary Arteriosclerosis; Coronary artery; Diagnostic; Diagnostic tests; Disease; Disease Association; Disease Progression; Environment; Etiology; Evaluation Studies; Faculty; Foundations; Framingham Heart Study; Funding; Future; General Hospitals; Goals; Grant; Health; Image; Infarction; Injury; Institution; Institutional National Research Service Award; Leadership; Manuscripts; Massachusetts; Measures; Mentors; Mid-Career Clinical Scientist Award (K24); Multicenter Trials; Myocardial; Myocardial Ischemia; N.I.H. Research Support; Obesity; Outcome; Outcomes Research; Patients; Peer Review; Peer Review Grants; Positioning Attribute; Positron-Emission Tomography; Public Health Schools; Publications; Radiology Specialty; Randomized; Research; Research Personnel; Research Project Grants; Research Support; Risk; Risk Assessment; Risk Factors; Role; Staging; Stress Tests; Surrogate Markers; Testing; Time; Training; Training Programs; Triage; Troponin; United States National Institutes of Health; acute coronary syndrome; base; cardiovascular imaging; career; experience; improved; innovation; medical schools; patient oriented research; professor; programs; prospective; radiologist; skills; standard of care; stem; tomography; treatment as usual; vascular bed

DESCRIPTION (provided by applicant): The applicant; Udo Hoffmann MD MPH is a clinically active staff radiologist in the Division of Cardiac Imaging at Massachusetts General Hospital and an Associate Professor of Radiology at Harvard Medical School. Over the last 10 years Dr. Hoffmann's research has focused on the feasibility, accuracy, and clinical utility of advanced cardiovascular imaging, specifically the role of cardiac CT in ischemic heart disease. Dr. Hoffmann's prior mentoring experience, his publication and funding record together with his current and planned research support in "Cardiovascular Imaging in Ischemic Heart Disease" demonstrate his commitment and passion for Patient Oriented Research and provide an excellent foundation to accomplish the goals and objectives of the K24 Award. The specific aims addressing the purpose of the K24 Award are: 1) To enable Dr. Hoffmann to dedicate 25% of his time to mentor junior clinical investigators based on already NIH funded projects in "Cardiovascular Imaging in Ischemic Heart Disease"; 2) To mentor junior clinical investigators from the T-32 program and the pool of residents, fellows, and junior faculty in Cardiology and Radiology with the goal to develop them into clinical researchers who can successfully compete for peer reviewed grants; and 3) To enable Dr. Hoffmann to further establish a patient orientated research program that combines innovative translational, clinical, and outcomes research in cardiovascular imaging and that provides an ideal environment to develop future leaders in clinical research. Dr. Hoffmann's role as the Director of the Cardiac MR CT PET Program, a clinical research program in cardiovascular imaging supported by the Division of Cardiology and the Department of Radiology and Dr. Hoffmann's responsibilities as the Co-director of a T32 training grant in cardiovascular imaging, in addition to the strong commitment he received from the leadership of both Cardiology and Radiology provide an environment that is ideal to successfully mentor junior clinical investigators and fulfill the purpose of the K24 Award. The specific research aims of this grant stem from a significant body of work accomplished over the past few years and are all based on on-going NIH funded projects, except Aim 4 which is new research specifically supported by this grant: 1) Subclinical Cardiovascular Disease - Association with Risk factors and Clinical Outcomes in the Framingham Heart Study, 2) Comparing Competing Diagnostic Strategies to Triage Patients with Acute Chest Pain in the ED - A Randomized Diagnostic Multicenter Trial with the major goal to determine whether cardiac CT is more efficient in the management of patients with acute chest pain than standard of care, 3) Comparing Competing Diagnostic Strategies in the Patients with Stable Chest Pain - Diagnostic Efficiency of Cardiac CT vs. Standard of Care - The "Prospective Multicenter Imaging Study for Evaluation of Chest Pain" (PROMISE), and 4) Combining high sensitivity troponin, a new improved biomarker assay, with cardiac CT to determine the etiology of myocardial injury and improve the efficacy of detecting acute coronary syndrome due to coronary artery disease.

申请人：Udo Hoffmann医学硕士，是马萨诸塞州总医院心脏成像科的临床在职放射科人员，哈佛医学院放射学副教授。在过去的10年里，霍夫曼博士的研究重点是先进的心血管成像的可行性、准确性和临床实用性，特别是心脏CT在缺血性心脏病中的作用。霍夫曼博士以前的指导经验、他的出版物和资助记录，以及他目前和计划在“缺血性心脏病的心血管成像”中提供的研究支持，表明了他对以患者为导向的研究的承诺和热情，并为实现K24奖的目标和目的奠定了良好的基础。K24奖的具体目的是：1)使霍夫曼博士能够将他25%的时间用于指导初级临床研究人员，这些研究基于已经由美国国立卫生研究院资助的“缺血性心脏病的心血管成像”项目；2)指导T-32项目的初级临床研究人员以及心脏病和放射学的住院医师、研究员和初级教员，目标是将他们培养成能够成功竞争同行评审拨款的临床研究人员；以及3)使霍夫曼博士能够进一步建立一个以患者为中心的研究计划，将心血管成像领域的创新转化、临床和结果研究结合起来，为培养未来的临床研究领导者提供理想的环境。霍夫曼博士作为心脏MR CT正电子发射计算机断层扫描计划(心脏MR CT PET计划)的主任，该计划是一项由心脏科和放射科支持的心血管成像临床研究计划，以及霍夫曼博士作为心血管成像T32培训补助金的联席主任的职责，再加上他从心脏病学和放射学的领导层得到的坚定承诺，他提供了一个理想的环境，可以成功指导初级临床研究人员，并实现K24奖的目的。这笔赠款的具体研究目标来自过去几年完成的大量工作，都基于正在进行的NIH资助的项目，除了目标4，这是由这笔赠款特别支持的新研究：1)亚临床心血管疾病-与弗雷明翰心脏研究中的风险因素和临床结果的关联，2)比较ED-A随机诊断多中心试验中对急性胸痛患者进行分类的竞争诊断策略，主要目标是确定心脏CT在管理急性胸痛患者方面是否比标准护理更有效，3)比较稳定性胸痛患者的相互竞争的诊断策略--心脏CT的诊断效率与护理标准--“评估胸痛的前瞻性多中心成像研究”(Promise多中心成像研究)，以及4)将一种新的改进生物标志物--高灵敏度肌钙蛋白与心脏CT相结合，以确定心肌损伤的病因，并提高检测冠状动脉疾病急性冠脉综合征的效率。