Cardiovascular Imaging in Ischemic Heart Disease

缺血性心脏病的心血管成像

• 批准号: 8495408
• 负责人: UDO HOFFMANN
• 金额: $ 12.79万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8495408
• 关键词: Acute; Address; Anatomy; Ancillary Study; Atherosclerosis; Biological Assay; Biological Markers; Blood; Cardiac; Cardiology; Cardiovascular Diseases; Charge; Chest Pain; Clinical; Clinical Investigator; Clinical Research; Computer Assisted; Coronary Arteriosclerosis; Coronary artery; Diagnostic; Diagnostic tests; Disease; Disease Association; Disease Progression; Environment; Etiology; Evaluation Studies; Faculty; Foundations; Framingham Heart Study; Funding; Future; General Hospitals; Goals; Grant; Health; Image; Infarction; Injury; Institution; Institutional National Research Service Award; Leadership; Manuscripts; Massachusetts; Measures; Mentors; Mid-Career Clinical Scientist Award (K24); Multicenter Trials; Myocardial; Myocardial Ischemia; N.I.H. Research Support; Obesity; Outcome; Outcomes Research; Patients; Peer Review; Peer Review Grants; Positioning Attribute; Positron-Emission Tomography; Public Health Schools; Publications; Radiology Specialty; Randomized; Research; Research Personnel; Research Project Grants; Research Support; Risk; Risk Assessment; Risk Factors; Role; Staging; Stress Tests; Surrogate Markers; Testing; Time; Training; Training Programs; Triage; Troponin; United States National Institutes of Health; acute coronary syndrome; base; cardiovascular imaging; career; experience; improved; innovation; medical schools; patient oriented research; professor; programs; prospective; radiologist; skills; standard of care; stem; tomography; treatment as usual; vascular bed

DESCRIPTION (provided by applicant): The applicant; Udo Hoffmann MD MPH is a clinically active staff radiologist in the Division of Cardiac Imaging at Massachusetts General Hospital and an Associate Professor of Radiology at Harvard Medical School. Over the last 10 years Dr. Hoffmann's research has focused on the feasibility, accuracy, and clinical utility of advanced cardiovascular imaging, specifically the role of cardiac CT in ischemic heart disease. Dr. Hoffmann's prior mentoring experience, his publication and funding record together with his current and planned research support in "Cardiovascular Imaging in Ischemic Heart Disease" demonstrate his commitment and passion for Patient Oriented Research and provide an excellent foundation to accomplish the goals and objectives of the K24 Award. The specific aims addressing the purpose of the K24 Award are: 1) To enable Dr. Hoffmann to dedicate 25% of his time to mentor junior clinical investigators based on already NIH funded projects in "Cardiovascular Imaging in Ischemic Heart Disease"; 2) To mentor junior clinical investigators from the T-32 program and the pool of residents, fellows, and junior faculty in Cardiology and Radiology with the goal to develop them into clinical researchers who can successfully compete for peer reviewed grants; and 3) To enable Dr. Hoffmann to further establish a patient orientated research program that combines innovative translational, clinical, and outcomes research in cardiovascular imaging and that provides an ideal environment to develop future leaders in clinical research. Dr. Hoffmann's role as the Director of the Cardiac MR CT PET Program, a clinical research program in cardiovascular imaging supported by the Division of Cardiology and the Department of Radiology and Dr. Hoffmann's responsibilities as the Co-director of a T32 training grant in cardiovascular imaging, in addition to the strong commitment he received from the leadership of both Cardiology and Radiology provide an environment that is ideal to successfully mentor junior clinical investigators and fulfill the purpose of the K24 Award. The specific research aims of this grant stem from a significant body of work accomplished over the past few years and are all based on on-going NIH funded projects, except Aim 4 which is new research specifically supported by this grant: 1) Subclinical Cardiovascular Disease - Association with Risk factors and Clinical Outcomes in the Framingham Heart Study, 2) Comparing Competing Diagnostic Strategies to Triage Patients with Acute Chest Pain in the ED - A Randomized Diagnostic Multicenter Trial with the major goal to determine whether cardiac CT is more efficient in the management of patients with acute chest pain than standard of care, 3) Comparing Competing Diagnostic Strategies in the Patients with Stable Chest Pain - Diagnostic Efficiency of Cardiac CT vs. Standard of Care - The "Prospective Multicenter Imaging Study for Evaluation of Chest Pain" (PROMISE), and 4) Combining high sensitivity troponin, a new improved biomarker assay, with cardiac CT to determine the etiology of myocardial injury and improve the efficacy of detecting acute coronary syndrome due to coronary artery disease.

描述（由申请人提供）：申请人； Udo Hoffmann MD MPH是马萨诸塞州综合医院心脏成像部门的临床活跃人员放射科医生，也是哈佛医学院放射学副教授。在过去的十年中，霍夫曼博士的研究集中在晚期心血管成像的可行性，准确性和临床实用性上，特别是心脏CT在缺血性心脏病中的作用。霍夫曼博士先前的指导经验，他的出版和资金记录，以及他当前和计划的研究支持“缺血性心脏病的心血管成像”，这表明了他对以患者为导向的研究的承诺和热情，并为实现K24奖的目标和目标提供了出色的基础。针对K24奖的目的的具体目的是：1）使Hoffmann博士能够将他的25％的时间用于指导初级临床研究人员，该研究人员基于NIH资助的“缺血性心脏病中的心血管成像”的项目； 2）指导来自T-32计划的初级临床研究人员以及心脏病学和放射学领域的居民，研究员和初级教师的库，目的是将其发展为临床研究人员，这些研究人员可以成功竞争获得同行评审的竞争； 3）为了使霍夫曼博士进一步建立一个以患者为导向的研究计划，该计划结合了心血管成像中创新的转化，临床和结果研究，并为培养临床研究的未来领导者提供了理想的环境。 Dr. Hoffmann's role as the Director of the Cardiac MR CT PET Program, a clinical research program in cardiovascular imaging supported by the Division of Cardiology and the Department of Radiology and Dr. Hoffmann's responsibilities as the Co-director of a T32 training grant in cardiovascular imaging, in addition to the strong commitment he received from the leadership of both Cardiology and Radiology provide an environment that is ideal to successfully mentor junior clinical调查人员并履行K24奖的目的。 The specific research aims of this grant stem from a significant body of work accomplished over the past few years and are all based on on-going NIH funded projects, except Aim 4 which is new research specifically supported by this grant: 1) Subclinical Cardiovascular Disease - Association with Risk factors and Clinical Outcomes in the Framingham Heart Study, 2) Comparing Competing Diagnostic Strategies to Triage Patients with Acute Chest Pain in the ED - A Randomized Diagnostic Multicenter Trial with the major goal to determine whether cardiac CT is more efficient in the management of patients with acute chest pain than standard of care, 3) Comparing Competing Diagnostic Strategies in the Patients with Stable Chest Pain - Diagnostic Efficiency of Cardiac CT vs. Standard of Care - The "Prospective Multicenter Imaging Study for Evaluation of Chest Pain" (PROMISE), and 4) Combining high sensitivity troponin, a new improved biomarker assay, with cardiac CT确定心肌损伤的病因并提高因冠状动脉疾病引起的急性冠状动脉综合征的功效。