Cardiovascular Imaging in Ischemic Heart Disease

缺血性心脏病的心血管成像

• 批准号: 9914877
• 负责人: UDO HOFFMANN
• 金额: $ 12.09万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2021-03-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9914877
• 关键词: Achievement; Acute; Address; Age; Antiinflammatory Effect; Area; Blood Vessels; Cardiac; Cardiology; Cardiovascular system; Case-Control Studies; Charge; Chest Pain; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Clinical/Radiologic; Coronary; Coronary Arteriosclerosis; Data; Environment; Epidemiology; Evaluation Studies; Event; Faculty; Foundations; Framingham Heart Study; Funding; Future; Goals; Grant; HIV; Journals; Machine Learning; Measurement; Measures; Medical; Mentors; Mid-Career Clinical Scientist Award (K24); Myocardial Ischemia; National Heart, Lung, and Blood Institute; Natural History; Outcome; Outcomes Research; Paper; Participant; Patients; Peer Review; Peer Review Grants; Placebos; Population; Positioning Attribute; Positron-Emission Tomography; Public Health Schools; Publications; Publishing; Radiology Specialty; Randomized; Randomized Controlled Trials; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Risk stratification; Syndrome; Techniques; Testing; Time; Training Programs; Translational Research; United States National Institutes of Health; base; cardiovascular imaging; career; comparative effectiveness trial; coronary plaque; cost; cost effectiveness; experience; follow-up; high risk; imaging biomarker; imaging study; improved; indexing; innovation; markov model; medical schools; member; novel; patient oriented research; predictive marker; prevent; professor; programs; prospective; radiomics; randomized trial; repository; sex; skills; synergism; training opportunity

Project Summary/Abstract The applicant Udo Hoffmann MD MPH is a Professor of Radiology at Harvard Medical School and the Chief of the Division for Cardiovascular Imaging in the Department of Radiology at MGH. Dr. Hoffmann has established a patient oriented research (POR) program that combines innovative translational, clinical, and outcomes research methods to demonstrate the value of advanced cardiovascular imaging. Dr. Hoffmann has published approximately 380 peer reviewed papers, among them many in premier medical journals and has received continued independent, peer-reviewed POR NIH funding since 2005. He is among the very few faculty members at Harvard Medical School who are both the PI and Director of a highly successful NHLBI funded T- 32 program (Cardiac MR and CT Research) and a recipient of a K24. Dr. Hoffmann has successfully mentored more than 60 clinical investigators, most of which currently hold faculty positions in major academic centers and actively perform POR. Moreover, Dr. Hoffmann has successfully accomplished all mentoring and scientific goals of the first K24 award period. Overall, these achievements document Dr. Hoffmann's long standing passion and commitment to POR. His excellent publication, funding, and mentoring record together with his current and planned research support provide an excellent foundation to accomplish the aims of this competitive renewal of the K24 Award “Cardiovascular Imaging in Ischemic Heart Disease”. Dr. Hoffmann proposes a mentoring and research plan that utilizes the synergies of past, ongoing, and future highly innovative independent research projects with educational and training opportunities offered by the cardiac MR CT PET Program, the T32 training program in cardiovascular imaging, the Harvard CTSA, and the Harvard School of Public Health. The specific aims addressing the charge of the K24 Award are to enable Dr. Hoffmann to: 1) dedicate 25% of his time to mentor clinical investigators based on NIH or equivalent funded projects in “Cardiovascular Imaging in Ischemic Heart Disease”, 2) to mentor junior and mid-career clinical investigators with the goal to develop them into clinical researchers who can successfully compete for peer reviewed grants, and 3) to continue to expand a POR program that combines translational, clinical, and outcomes research to develop future leaders in clinical research in cardiovascular imaging and beyond. The research plan encompasses four specific aims: 1) To determine the effects of statin treatment on coronary atherosclerosis in HIV patients in 800 patients with HIV randomized to statin therapy vs. placebo, 2) To determine whether high risk coronary plaque predicts cardiovascular events in 4600 patients with clinical suspicion of CAD, 3) To determine the cost effectiveness of CT FFR in patients with stable and acute chest pain, and 4) To use Radiomics to identify novel imaging markers predicting cardiovascular events in participants of the Framingham Heart Study.

项目总结/摘要 申请人Udo Hoffmann MD MPH是哈佛医学院的放射学教授， 麻省总医院放射科心血管影像科。霍夫曼医生已经证实 一个以患者为导向的研究（POR）计划，结合了创新的翻译，临床和成果 研究方法，以证明先进的心血管成像的价值。霍夫曼博士发表了 约380篇同行评审论文，其中许多发表在顶级医学期刊上，并已收到 自2005年以来，持续的独立，同行评审的POR NIH资助。他是为数不多的 成员在哈佛医学院谁是PI和主任的一个非常成功的NHLBI资助的T- 32程序（心脏MR和CT研究）和K24的接受者。霍夫曼博士成功地指导了 超过60名临床研究人员，其中大多数目前在主要学术中心担任教职 并积极进行POR。此外，霍夫曼博士成功地完成了所有的指导和科学。 第一个K24奖项的目标。总的来说，这些成就证明了霍夫曼博士长期以来 对POR的热情和承诺。他出色的出版、资助和指导记录， 目前和计划中的研究支持为实现这一目标提供了良好的基础 K24奖“缺血性心脏病心血管成像”的竞争性更新。霍夫曼医生 提出了一个指导和研究计划，利用过去的协同作用，正在进行的，和未来的高度 创新的独立研究项目，提供心脏MR的教育和培训机会 CT PET计划、T32心血管成像培训计划、哈佛CTSA和哈佛 公共卫生学院。解决K24奖的具体目标是使霍夫曼博士 1）将25%的时间用于指导基于NIH或同等资助项目的临床研究者， “缺血性心脏病的心血管成像”，2）指导初级和中级临床研究人员 目标是将他们培养成能够成功竞争同行评审赠款的临床研究人员， 3）继续扩大POR计划，将转化，临床和结果研究相结合， 培养心血管成像及其他领域临床研究的未来领导者。研究计划 包括四个具体的目标：1）确定他汀类药物治疗对冠状动脉粥样硬化的影响， 800例HIV患者随机接受他汀类药物治疗与安慰剂治疗，2）为了确定是否高 在4600例临床怀疑CAD的患者中，危险冠状动脉斑块预测心血管事件，3） 确定CT血流储备分数在稳定型和急性胸痛患者中的成本效益，以及4）使用 放射组学用于识别新的影像学标记物，以预测参与者的心血管事件 弗雷明汉心脏研究。

项目成果

Reply: High-risk plaque detected on coronary CT angiography predicts acute coronary syndrome.

答：冠状动脉CT血管造影检测到高危斑块可预测急性冠状动脉综合征。

• DOI: 10.1016/j.jacc.2014.11.051
• 发表时间: 2015
• 期刊: Journal of the American College of Cardiology
• 影响因子: 24
• 作者: Ferencik,Maros;Puchner,StefanB;Hoffmann,Udo
• 通讯作者: Hoffmann,Udo

Erratum to: Outcomes of anatomical vs. functional testing for coronary artery disease : Lessons from the major trials.

勘误表：冠状动脉疾病的解剖与功能测试的结果：主要试验的教训。

• DOI: 10.1007/s00059-020-04968-2
• 发表时间: 2020
• 期刊: Herz
• 影响因子: 1.7
• 作者: Karády,Júlia;Taron,Jana;Kammerlander,AndreasAnselm;Hoffmann,Udo
• 通讯作者: Hoffmann,Udo

Clinical implementation of an emergency department coronary computed tomographic angiography protocol for triage of patients with suspected acute coronary syndrome.

• DOI: 10.1007/s00330-016-4562-5
• 发表时间: 2017-07
• 期刊: European radiology
• 影响因子: 5.9
• 作者: Ghoshhajra BB;Takx RAP;Staziaki PV;Vadvala H;Kim P;Neilan TG;Meyersohn NM;Bittner D;Janjua SA;Mayrhofer T;Greenwald JL;Truong QA;Abbara S;Brown DFM;Januzzi JL;Francis S;Nagurney JT;Hoffmann U;MGH Emergency Cardiac CTA Program Contributors
• 通讯作者: MGH Emergency Cardiac CTA Program Contributors

Noninvasive FFR Derived From Coronary CT Angiography: Management and Outcomes in the PROMISE Trial.

• DOI: 10.1016/j.jcmg.2016.11.024
• 发表时间: 2017-11
• 期刊: JACC. Cardiovascular imaging
• 作者: Lu MT;Ferencik M;Roberts RS;Lee KL;Ivanov A;Adami E;Mark DB;Jaffer FA;Leipsic JA;Douglas PS;Hoffmann U
• 通讯作者: Hoffmann U

High-Risk Coronary Plaque on Computed Tomography Angiography: Time to Recognize a New Imaging Risk Factor.

计算机断层扫描血管造影中的高风险冠状动脉斑块：是时候识别新的成像风险因素了。

• DOI: 10.1161/circimaging.117.007288
• 发表时间: 2018
• 期刊: Circulation. Cardiovascular imaging
• 作者: Ferencik,Maros;Hoffmann,Udo
• 通讯作者: Hoffmann,Udo